Record Display for the EPA National Library Catalog


Main Title Cytogenetic Studies of Mice Exposed to Styrene by Inhalation.
Author Kligerman, A. D. ; Allen, J. W. ; Bryant, M. F. ; Campbell, J. A. ; Collins, B. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher 1992
Year Published 1992
Report Number EPA/600/J-93/403;
Stock Number PB93-236404
Additional Subjects Chromosome aberrations ; Styrene ; Mutagens ; Mice ; Respiration ; Sister chromatid exchange ; Spleen ; Lung ; Micronucleus tests ; Graphs(Charts) ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-236404 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
The data for the in vivo genotoxicity of styrene (STY) are equivocal. To evaluate the clastogenicity and sister-chromatid exchange (SCE)-inducing potential of STY in vivo under carefully controlled conditions, B6C3F1 female mice were exposed by inhalation for 6 h/day for 14 consecutive days to either 0, 125, 250 or 500 ppm STY. One day after the final exposure, peripheral blood, spleen, and lungs were removed and cells were cultured for the analysis of micronucleus (MN) induction using the cytochalasin B-block method, chromosome breakage, and SCE induction. Peripheral blood smears were also made for scoring MN in erythrocytes. There was a significant concentration-related elevation of SCE frequency in lymphocytes from the spleen and the peripheral blood as well as in cells from the lung. However, no statistically significant concentration-related increases were found in the frequency of chromosome aberrations in the cultured splenocytes or lung cells, and no significant increases in MN frequencies were observed in binucleated splenocytes or normochromatic erythrocytes in peripheral blood smears. (Copyright (c) 1992 Elsevier Science Publishers B.V.)