Record Display for the EPA National Library Catalog


Main Title Effect of Ventilation and Perfusion Imbalance on Inert Gas Rebreathing Variables.
Author Friedman, M. ; Wilkins, S. A. ; Rothfeld, A. F. ; Bromberg, P. A. ;
CORP Author North Carolina Univ. at Chapel Hill. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1984
Report Number EPA-R-805184; EPA/600/J-84/170;
Stock Number PB85-144087
Additional Subjects Respiratory system ; Lungs ; Gases ; Dogs ; Laboratory animals ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB85-144087 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 7p
The effects of ventilation-to-perfusion (Va/Qc) maldistribution within the lungs on measured multiple gas rebreathing variables were studied in 14 dogs. The rebreathing method (using He, C18C, and C2H2) allows for measurements of pulmonary capillary blood flow (Qc), diffusing capacity (DLco), lung gas volume, and the combined pulmonary tissue and capillary blood volume (VTPC). Va/Qc imbalance was created by reversibly occluding the right main pulmonary artery or by reversibly obstructing the left main bronchus in eight dogs. Six additional dogs were ventilated with 10 cmH2O positive end-expiratory pressure (PEEP) to create a bimodal distribution of Va/Qc within the lungs. No significant alterations in computed rebreathing variables, except for a small (14%) decrease in DLco, occured during right main pulmonary artery occlusion, whereas obstruction of the left main bronchus caused parallel decreases (mean of 46%) in all rebreathing variables.