Record Display for the EPA National Library Catalog


Main Title Genetic Toxicology of Benzoin and Caprolactam.
Author Brady, A. L. ; Stack, H. F. ; Waters, M. D. ;
CORP Author Environmental Health Research and Testing, Inc., Research Triangle Park, NC.;Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div.
Publisher c1989
Year Published 1989
Report Number EPA-68-02-4456; EPA/600/J-89/384;
Stock Number PB90-216151
Additional Subjects Toxicology ; Mutations ; Bioassay ; Tables(Data) ; Drosophila ; Salmonella typhimurium ; Saccharomyces ; Reprints ; Mutagenicity tests ; Caprolactan ; Benzoin ; Transformed cell line
Library Call Number Additional Info Location Last
NTIS  PB90-216151 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 15p
Based on animal carcinogenesis studies, benzoin and caprolactam have been classified as noncarcinogens. The genetic toxicity of both compounds has been thoroughly evaluated in short-term in vitro bioassays. Genetic activity profiles and corresponding data listings and summaries are presented for benzoin and caprolactam. Generally weak positive responses were obtained with benzoin only in mammalian cell mutagenesis and cell transformation assays. In the case of caprolactam, reproducible positive responses were obtained for somatic mutations in Drosophila and for mammalian cell transformation (in different cell lines) at high dose levels. Since the chemical structures of benzoin and caprolactam do not suggest the potential for genotoxicity, these responses may be associated with nonspecific toxicity. The overwhelming majority of short-term test data suggest that, in accordance with animal cancer data, benzoin and caprolactam are not genotoxic. (Copyright (c) Elsevier Science Publishers B. V. (Biomedical Division).)