Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Investigations of Amitraz Neurotoxicity in Rats. 1. Effects on Operant Performance (Journal Version).
Author Moser, V. C. ; Boyes, W. K. ; MacPhail, R. C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Publisher 1987
Year Published 1987
Report Number EPA/600/J-87/402;
Stock Number PB89-105910
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Reprints ; Neurotoxicity ; Amitraz ; Operant performance
Library Call Number Additional Info Location Last
NTIS  PB89-105910 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/14/1989
Collation 11p
Amitraz (AMZ), a formamidine pesticide, displayed a unique spectrum of neurobehavioral effects which differed from that of the prototypic formamidine, chlordimeform (CDM). In male Long-Evans rats, general signs of intoxication included hypothermia, hyperreactivity, vasodilation, profound weight loss, aggression, and extreme reactions to handling. These effects required days to weeks for recovery, and were cumulative with short-term repeated administration. AMZ produced differential effects on multiple-schedule performance that were distinct from the effects of CDM. Moreover, the marked signs of intoxication, and effects on schedule-controlled behavior following high doses (>50 mg/kg), were persistent and cumulative on repeated administration.