Record Display for the EPA National Library Catalog


Main Title Combined Effects of Solvents on the Rat's Auditory System: Styrene and Trichloroethylene.
Author Rebert, C. S. ; Boyes, W. K. ; Pryor, G. T. ; Svensgaard, D. J. ; Kassay, K. M. ;
CORP Author SRI International, Menlo Park, CA. Neuroscienc Dept.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/339;
Stock Number PB93-229573
Additional Subjects Solvents ; Styrene ; Trichloroethylene ; Hearing loss ; Dose-response relationships ; Auditory evoked potentials ; Rats ; Hair cells ; Cochlea ; Statistical analysis ; Blood chemical analysis ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-229573 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Because exposures to toxic agents typically involve more than one substance, it is necessary to know if combined exposures pose different risks than those to single agents. Many solvents have been implicated in central nervous disorders and some of them are known to produce hearing loss, probably mediated by damage to cochlear hair cells. Hearing loss was studied by recording the brainstem auditory evoked response (BAER) in male Long Evans rats exposed 8 h/day for 5 days to mixtures of styrene (STY) and trichloroethylene (TCE). Dose groups included air or solvent pairs (STY/TCE) in the following concentrations (ppm): (0:3000), (250:2250), (500:1500), (750:750) and (1000:0). Decreased BAER amplitude, indicative of hearing loss, was correlated with blood levels of total solvent. The effects were as predicted by a linear dose-addition model, indicating neither synergistic nor antagonistic interactions at the concentrations studied. (Copyright (c) 1993 Elsevier Science Publishers B.V.)