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Main Title Prolonged Neurobehavioral and Visual Effects of Short-Term Exposure to 3,3'-Iminodipropionitrile (IDPN) in Rats.
Author Moser, V. C. ; Boyes, W. K. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. Neurotoxicology Div. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-94/069;
Stock Number PB94-141579
Additional Subjects Toxicology ; Vision ; Behavior ; Nervous system ; Rats ; Visual evoked potentials ; Dose-response relationships ; Motor activity ; Hypothermia ; Reprints ; Nitrile/iminodipropio
Library Call Number Additional Info Location Last
NTIS  PB94-141579 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 16p
Strategies for neurotoxicity testing often include initial screening tests, such as a functional observational battery (FOB) and motor activity assessment, followed by detailed characterization studies. In this study, a neurobehavioral screening battery (FOB and motor activity) was used to evaluate the effects of 3-day repeated exposure to 0, 100, 200, or 400 mg/kg/day 3,3'-iminodipropionitrile (IDPN). Adult Long-Evans rats (males and females) were tested before dosing and 1, 14, 28, 56, and 91 days after the third dose. IDPN initially produced generalized CNS depression, weakness, and hypothermia. Thereafter, marked hyperactivity, increased excitability, decreased reactivity to visual and auditory stimuli, neuromuscular weakness, equilibrium changes, and a 'waltzing syndrome' (vertical and lateral head movements, circling, and retropulsion) emerged and persisted for 3 months. Males were more severely affected than females. Following neurobehavioral testing, the rats were examined for visual function using flash (three intensities) and pattern (three pattern sizes by three contrast levels)-elicited visual evoked potentials (VEPs). IDPN produced changes in pattern- and flash-elicited VEPs, thus verifying predictions made from the screening tests. (Copyright (c) 1993 Society of Toxicology.)