| Main Title |
Movement of Mercury in Rat Submaxillary Slices. |
| Author |
Smith, Ladd W. ;
Borzelleca, Joseph F. ;
|
| CORP Author |
Medical Coll. of Virginia, Richmond. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1980 |
| Report Number |
EPA-R-804318; EPA-600/J-80-339; |
| Stock Number |
PB82-118191 |
| Additional Subjects |
Mercury(Metal) ;
Nitrogen ;
Inhibitors ;
Rats ;
Tissues(Biology) ;
Concentration(Composition) ;
Metals ;
Pathology ;
Reprints ;
Submandibular gland
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB82-118191 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The movement of HgCl2 was studied in slices of rat submaxillary gland. A steady-state distribution was reached within 60 min. N2 or metabolic inhibitors failed to decrease tissue uptake. Increasing the concentration of Hg2+ produced a corresponding increase in tissue metal. Decreasing the incubation temperature decreased uptake. Cd2+ and Fe2+ decreased uptake but Zn2+, Cu2+, and Fe3+ were without effect. Efflux experiments indicated a firm binding of Hg2+. The data suggest a passive uptake for Hg2+ with unsaturable, temperature-sensitive binding sites in the interior of the cell. |
