Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Study of Intermolecular Complexes of Bis (p-Chlorophenyl) Acetic Acid and Some Biologically Significant Compounds.
Author Ross, Ralph T. ; Biros., Francis J. ;
CORP Author Environmental Protection Agency, Perrine, Fla. Primate and Pesticides Effects Lab.
Year Published 1973
Stock Number PB-274 733
Additional Subjects Chlorine organic compounds ; Pesticides ; Nuclear magnetic resonance ; Molecular relaxation ; Toxicity ; DDT ; Insecticides ; Reprints ; Acetic acid/bis(chlorophenyl) ; Chemical shifts(Nuclear magnetic resonance)
Library Call Number Additional Info Location Last
NTIS  PB-274 733 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 10p
The results of this investigation have shown that with the use of high resolution NMR relaxation measurement studies, some insight into the importance of molecular binding of p,p'-DDA with BSA and HSA may be obtained. The binding phenomena may be interpreted in terms of preferential stabilization of the aromatic rings by binding sites on the BSA and HSA molecules. This was demonstrated by the greater relaxation rates found for the aromatic protons of the p,p'-DDA than those of the alpha-methine proton. These relaxation rates were quite pD dependent as would be expected from a specific binding mechanism. The binding of p,p'-DDA.BSA and p,p'-DDA.HSA is hydrophobic in nature since a direct relationship was found with ionic strength and relaxation times. The relaxation rates of both complexes increase with decrease in temperature.