Record Display for the EPA National Library Catalog


Main Title Effects of selected asbestos fibers on cellular and molecular parameters /
Author Hart, R. W. ; Fertel, R. ; Newman, H. A. I. ; Daniel, F. B. ; Blakeslee, J. R.
Other Authors
Author Title of a Work
Millette, James R.
Hart, Ronald W.
CORP Author Ohio State University. Chemical Biomedical Environmental Research Group.
Publisher Health Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency ; Available from National Technical Information Service,
Year Published 1979
Report Number EPA-600/1-79-021; EPA-R-804201
Stock Number PB-299 199
OCLC Number 05513539
Subjects Asbestos fibers--Environmental aspects ; Asbestos--Toxicology ; Asbestos--toxicity ; Environmental Exposure
Additional Subjects Asbestos ; Toxicology ; Deoxyribonucleic acids ; Revisions ; In vitro analysis ; Tissue culture ; Laboratory animals ; Serpentine ; Amphiboles ; Cellular materials ; Molecular structure ; Cultures(Biology) ; Toxic substances ; Cytoxicity ; Carcinogenesis ; Environmental health
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-79-021 Headquarters Library/Washington,DC 04/24/2014
EKBD  EPA-600/1-79-021 Research Triangle Park Library/RTP, NC 04/17/2019
ELBD ARCHIVE EPA 600-1-79-021 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB-299 199 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation xi, 35 pages : charts ; 28 cm.
Embryonic cultures were used to compare the effects of five asbestos materials on a cellular, biochemical and molecular basis. Chrysotile was found to be the most cytotoxic followed by crocidolite, tremolite, amosite, and silica. Results of tests involving cellular ratios of cyclic nucleotides were consistent with asbestos acting as a promoter of carcinogenesis. Washed asbestos fibers had little or no effect on induction of DNA damage based on unscheduled DNA synthesis tests.
"EPA 600/1-79-021"--Cover. "May 1979"--Cover. "Grant No. R-804201." "Project Officer James R. Millette Exposure Evaluation Branch Health Effects Research Laboratory." Includes bibliographical references.