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Main Title Assessment of Primary vs. Secondary Toxicity of Aroclor (Trade Name) 1254 to Mink.
Author Aulerich, R. J. ; Ringer, R. K. ; Safronoff, J. ;
CORP Author Michigan State Univ., East Lansing. Dept. of Animal Science.;Corvallis Environmental Research Lab., OR.
Publisher c1986
Year Published 1986
Report Number EPA-R-810785; EPA/600/J-86/505;
Stock Number PB90-106253
Additional Subjects Toxicity ; Animal physiology ; Concentration(Compounds) Carnivora ; Feeding stuffs ; Feeding habits ; Biomedical measurement ; Comparison ; Test methods ; Michigan ; Body weight ; Mortality ; Reprints ; Aroclor ; Polychlorobiphenyl compounds ; Animal models ; Xenobiotics ; Mink ; Mustela vison
Library Call Number Additional Info Location Last
NTIS  PB90-106253 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 9p
Dietary tests were conducted, using mink as a surrogate mammalian wildlife carnivore, to develop and evaluate procedures for the assessment of primary vs secondary toxicity of potentially hazardous chemicals to mammalian carnivores. Test methods included comparison of mortality, body weight change, feed consumption and calculated LC50 values in mink fed diets that contained polychlorinated biphenyls (PCBs), i.e., Aroclor 1254 (primary toxicity) with mink fed diets that contained the same concentrations of the metabolized xenobiotic (secondary toxicity). Mean feed consumption and body weight gains were lower for the mink fed the metabolized Aroclor 1254 (secondary toxicity) than for mink that received the same concentrations of Aroclor 1254. The test yielded 28- and 35-day LC50 values of 79.0 and 48.5 ppm (mg/kg) for the primary toxicity test and 47.0 and 31.5 ppm (mg/kg) for the secondary toxicity test, respectively. The results indicated that mink were a suitable carnivorous species for secondary toxicity testing. (Copyright (c) 1986 Springer-Verlag.)