Record Display for the EPA National Library Catalog


Main Title In vitro Mammalian Mutagenesis as a Model for Genetic Lesions in Human Cancer.
Author Hozier, J. ; Applegate, M. ; Moore, M. M. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Florida State Univ., Tallahassee. Dept. of Biological Science. ;Florida Inst. of Tech., Melbourne. Medical Genetics Lab.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/448;
Stock Number PB93-141471
Additional Subjects Carcinogenesis ; Toxicology ; Mutagenicity tests ; DNA mutational analysis ; DNA probes ; Cultured cells ; Mice ; Genetic markers ; Genetic models ; In vitro analysis ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB93-141471 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Molecular and cytogenetic analysis of mutations induced by a variety of genotoxic compounds at the heterozygous thymidine kinase locus in mouse lymphoma cells indicates that in vitro assay does indeed register the range of genetic lesions recently found in a wide variety of human tumors. The types and complexity of the induced lesions are reflected in mutant cell colony phenotype in a compound-specific fashion. These studies point to the use of appropriate in vitro mammalian mutagenesis assays as new model systems for dissecting the genetic lesions important to human carcinogenesis, and as a means of determining the potential for compounds to induce such lesions. (Copyright (c) 1992 Elsevier Science Publishers B.V.)