| Main Title |
Anomalous Phosphorylated Neurofilament Aggregations in Central and Peripheral Axons of Hens Treated with Tri-Ortho-Cresyl Phosphate (TOCP). |
| Author |
Jensen, K. F. ;
Lapadula, D. M. ;
Anderson, J. K. ;
Haykal-Coates, N. ;
Abou-Donia, M. B. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Duke Univ. Medical Center, Durham, NC. Dept. of Pharmacology. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-93/104; |
| Stock Number |
PB93-175735 |
| Additional Subjects |
Tritolyl phosphates ;
Axons ;
Intermediate filaments ;
Phosphorylation ;
Chickens ;
Kinases ;
Immunohistochemistry ;
Organophosphorus compounds ;
Peripheral nerves ;
Spinal cord ;
Reprints ;
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB93-175735 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
8p |
| Abstract |
Previous biochemical studies demonstrated a dramatic increase in phosphorylation of cytoskeletal proteins that occurs early in organophosphorus ester-induced delayed neurotoxicity (OPIDN). In the report the authors present immunohistochemical evidence that there is anomalous aggregation of phosphorylated neurofilaments within central and peripheral axons following organophosphate exposure. The morphology, location, and time of appearance of these aggregations are consistent with the hypothesis that the aberrant phosphorylation of cytoskeletal elements is an antecedent to the focal axonal swelling and degeneration characteristic of OPIDN. (Copyright (c) 1992 Wiley-Liss, Inc.) |
