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Main Title Physiologically Based Pharmacokinetic Model for 2,3,7,8-Tetrabromodibenzo-p-Dioxin (TBDD) in the Rat: Tissue Distribution and CYP1A Induction.
Author Kedderis, L. B. ; Mills, J. J. ; Andersen, M. E. ; Birnbaum, L. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;North Carolina Univ. at Chapel Hill. Curriculum in Toxicology. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/415;
Stock Number PB94-101565
Additional Subjects Pharmacokinetics ; Mathematical models ; Toxic substances ; Exposure ; Risk assessment ; Toxicology ; Rats ; Liver ; Enzyme induction ; Tissues(Biology) ; Radioimmunoassay ; Tetrachlorodibenzodioxin ; Reprints ; Dioxin/tetrabromodibenzo
Library Call Number Additional Info Location Last
NTIS  PB94-101565 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Biologically based models serve as valuable tools for integration of mechanistic pharmacokinetic data by their explicit definition of important determinants of chemical disposition. The objective of the present work was to develop a physiologically based pharmacokinetic model to describe the disposition and enzyme induction properties of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD). The TBDD model, which was based on models previously developed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), incorporated: ternary interactions between TBDD, the Ah receptor, and specific DNA-binding sites; induction of a TBDD-binding protein specific to the liver; and diffusion-limited tissue uptake. (Copyright (c) 1993 by Academic Press, Inc.)