Record Display for the EPA National Library Catalog


Main Title Assessment of the Hepatotoxicity of Acute and Short-Term Exposure to Inhaled p-Xylene in F-344 Rats.
Author Simmons, J. E. ; Allis, J. W. ; Grose, E. C. ; Seely, J. C. ; Robinson, B. L. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;PATHCO, Inc., Research Triangle Park, NC.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-91/058;
Stock Number PB91-191650
Additional Subjects Toxicity ; Xylenes ; Liver ; Air pollution effects(Animals) ; Rats ; Liver enzymes ; Metabolic activation ; Enzyme induction ; Body weight ; Organ weight ; Blood chemical analysis ; Dose-response relationships ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB91-191650 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 14p
Due to the ubiquitous presence of p-xylene in air and the existing uncertainty regarding its hepatotoxic potential, the authors examined the effect of acute and short-term exposure to inhaled p-xylene on the liver. Male F-344 rats were exposed to 0 or to 1600 ppm p-xylene, 6 h/d, for 1 or 3 d. Exposure to inhaled p-xylene caused no histopathological evidence of hepatic damage and had little or no effect on the serum levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, ornithine carbamyl transferase, alkaline phosphatase, and total bilirubin. Exposure to p-xylene for 1 or 3 d resulted in an increase in relative liver weight on d 1 post-exposure. The concentration of hepatic cytochrome P-450 was increased by both p-xylene exposure regimens on d 1 postexposure and had returned to control levels by d 3 following the single p-xylene exposure and by d 2 following the 3-d exposure. These observations provide consistent evidence that acute and short-term exposure to 1600 ppm p-xylene by inhalation did not produce overt hepatotoxicity but resulted in a significant increase in the concentration of hepatic cytochrome P-450, the principal enzyme system involved in the metabolic biotransformation of xenobiotics. (Copyright (c) 1991 by Hemisphere Publishing Corporation.)