| Main Title |
Kinetochore-Staining of Spermatid Micronuclei: Studies of Mice Treated with X-Radiation or Acrylamide. |
| Author |
Collins, B. W. ;
Howard, D. R. ;
Allen, J. W. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA/600/J-92/193; |
| Stock Number |
PB92-188994 |
| Additional Subjects |
X rays ;
Acrylamides ;
Spermatozoa ;
Micronuclei ;
Mice ;
Fluorescent antibody technique ;
Meiosis ;
Staining ;
Reprints ;
Kinetochores
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB92-188994 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
The rodent spermatid micronucleus (MN) assay was used in conjunction with immunofluorescent techniques to distinguish kinetochores in MN following exposure of mice to X-radiation or acrylamide. After either treatment, modest increases in kinetochore-positive MN were observed. Spermatids which had been exposed during meiotic prophase to X-rays (400 cGy) had approximately 10-fold increases in MN compared to controls; up to 15% of the MN observed were kinetochore-positive. Following acrylamide treatment of meiotic prophase cells, there was a doubling of spermatid MN over baseline levels, approximately one-third of which were kinetochore-positive. (Copyright (c) 1992 Elsevier Science Publishers B.V.) |
