||Guide for the 'Salmonella typhimurium'/Mammalian Microsome Tests for Bacterial Mutagenicity.
Claxton, L. D. ;
Allen, J. ;
Auletta, A. ;
Mortelmans, K. ;
Nestmann, E. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Glaxo, Inc., Research Triangle Park, NC. ;SRI International, Menlo Park, CA. ;Health and Welfare Canada, Ottawa (Ontario).
Salmonella tymphimurium ;
Ames test ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Since its development by Dr. Bruce Ames and his coworkers, the Salmonella typhimurium/mammalian microsome mutagenicity assay has been used widely throughout the world. Many authors have suggested various modifications and made recommendations in regards to the assay. Although the recommendations of a panel of experts was published in 1979 by deSerres and Shelby, a committee of members of the Environmental Mutagen Society (EMS) initiated this effort in response to the encouragement by the American Society of Testing and Materials (Committee E47.09.01) and because of new developments within the field of microbial mutagenesis tests, but it is not intended for these recommendations to replace or diminish the usefulness of presently available protocols and procedures.