Global climate change from increases in atmospheric carbon dioxide and other trace gases is an issue of international concern. Adverse climatic conditions are expected to reduce crop yields and alter the demand for and supply of water. These potential adjustments imply economic costs to agriculture and its constituents. The paper explores possible economic implications for U.S. agriculture, with particular reference to the West. Results from a series of spatial equilibrium model analyses suggest that climate change is not a food security issue for the United States. However, regional adjustments in agricultural production and associated resource use are expected.