Record Display for the EPA National Library Catalog

RECORD NUMBER: 17 OF 22

OLS Field Name OLS Field Data
Main Title Mechanisms of TCDD-Induction of Cleft Palate: Insights from In vivo and In vitro Approaches.
Author Abbott, B. D. ; Diliberto, J. J. ; Birnbaum, L. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Reproductive Toxicology Branch.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/442;
Stock Number PB93-141414
Additional Subjects Teratogenic compounds ; Toxicology ; Cleft palate ; Hydrocortisone ; Tretinoin ; Growth substances ; Tetrachlorodibenzodioxin ; Cultured cells ; Embryos ; Congenital abnormalities ; Fetal development ; In vivo analysis ; Palate ; Mice ; Cell differentiation ; In vitro analysis ; Reprints ; TCDD
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-141414 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/12/1993
Collation 6p
Abstract
Tetrachlorodibenzo-p-dioxin (TCDD) induced cleft palate (CP) in C57BL6N embryos by altering proliferation and differentiation of palatal medial epithelial cells. In palatal organ culture, concentration-dependent effects on medial epithelial cells occurred. The mechanism of TCDD activity appears to involve growth factor expression and may interact with retinoic acid and glucocorticoid pathways.