Record Display for the EPA National Library CatalogRECORD NUMBER: 2 OF 3
|Main Title||Teratogenic Evaluation of Ethylene Chlorhydrin (ECh, 2-Chlorethanol) in Mice.|
|Author||Courtney, K. Diane ; Andrews, James E. ; Grady, Margaret ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC.|
|Additional Subjects||Evaluations ; Mice ; Laboratory animals ; Ingestion(Biology) ; Dosage ; Chlorine organic compounds ; Environmental surveys ; Reprints ; Ethanol/chloro ; Teratogenesis|
ECh administered intragastrically to pregnant CD-1 mice from the 6th to the 16th day of gestation at a dose of 100 mg/kg produced a significant reduction in maternal weight gain and a decrease in fetal body weight and liver weight. A lower dose of 50 mg/kg had no consistent effect and a higher dose of 150 mg/kg was maternally lethal. Administration of ECh in the drinking water at doses of 16, 43, 77, or 227 mg/kg did not produce any adverse effects on maternal or fetal body weight, viability, or fetal development.