Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Sister-Chromatid Exchange Induction in Rat Maternal, Embryonic and Extra-Embryonic Cells After in vivo Exposure to 4-Nitroquinoline 1-Oxide.
Author Sharma, R. K. ; Dunn, R. ; Allen, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Year Published 1984
Report Number EPA/600/J-84/379;
Stock Number PB86-209798
Additional Subjects Toxicology ; In vivo analysis ; Rats ; Reprints ; Sister chromatid exchange ; Genotoxicity ; Nitroquinoline oxide
Library Call Number Additional Info Location Last
NTIS  PB86-209798 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 6p
Genetic damage is associated with various embryo pathologies; and many teratogens and transplacental carcinogens are known to be genotoxic. The present study was aimed at charaterizing SCE induction levels in rodent maternal, embryonic and extra-embryonic cells after maternal exposure to 4NQO. Tissue-specific assessments were made at various gestational ages, and thus stages of placental development. Embryo liver, and yolk sac - the malfunction of which has been implicated in teratogenic mechanisms were assessed with a particular view to whether they would show relatively low levels of SCE induction and thereby lend support to the concept of a protective placental barrier to 4NQO. A previously established rat system allowing for in vivo SCE induction analyses of maternal marrow and embryo liver or yolk sac was used for these studies.