Record Display for the EPA National Library Catalog

RECORD NUMBER: 5 OF 6

Main Title Kinetics Study of Chloride in Rat.
Author Suh, D. H. ; Abdel-Rahman, M. S. ;
CORP Author New Jersey Medical School, Newark. Dept. of Pharmacology.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-807473; EPA-600/J-83-197;
Stock Number PB84-178953
Additional Subjects Reaction kinetics ; Chlorides ; Toxicology ; Enviornmental surveys ; Ingestion(Biology) ; Rats ; Laboratory animals ; Bioassay ; Chlorination ; Water treatment ; Blood plasma ; Public health ; Chlorine oxides ; Sampling ; Disinfection ; Absorption ; Blood analysis ; Reprints ;
Holdings
Library Call Number Additional Info Location Last
Modified		 Checkout
Status
NTIS  PB84-178953 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
Abstract
The kinetics of chloride were studied in Sprague-Dawley rats following the oral administration of Na36Cl. The half-life for (36)Cl(-1) absorption from plasma was 19.2 hr corresponding to a rate constant of 0.0361 hr, while the half-life for (36)Cl(-1) elimination from plasma was 51.9 hr corresponding to a rate constant 0.0134 hr. At 120 hr, radioactivity was highest in plasma followed by kidney, lung, stomach and spleen, whereas the lowest activity was observed in fat. Plasma and packed cells contained almost the same concentration of (36)Cl(-1). Plasma protein binding of chloride was significantly higher than liver protein binding. Subcellular distribution in liver fractions revealed that most of the (36)Cl(-1) was located in the cytosolic fraction. The excretion of chloride occurred primarily by the kidney. (Copyright (c) 1983 by Hemisphere Publishing Corporation.)