Grantee Research Project Results
Research Centers
University of Medicine and Dentistry of New Jersey Center for Childhood Neurotoxicology and Assessment
University of Medicine and Dentistry of New Jersey
The main focus of the UMDNJ Children’s Center, established in 2002, is to examine the effects of environmental chemicals on neurological health and development, with an emphasis on the interaction between exposure to environmental factors, learning disabilities and autism spectrum disorders (ASD). Investigators at the UMDNJ Children’s Center have developed important basic and clinical science data, which has had a significant impact in the field.
The causes and contributing factors for ASD are poorly understood. Evidence suggests that incidence of ASD is increasing, now estimated at 1 in every 150 births, and the rate is higher for male children. Most cases seem likely to arise from a combination of an ever increasing array of genetic factors and additional environmental factors, while diagnostic changes and improvements may also be contributing to the increased rates.
Projects at the UMDNJ Children’s Center include developing animal models of features of autism such as regression of neurobehavioral function or self-injurious behavior, and developing animal models mimicking the genes linked to autism in humans. Through clinical studies of children with autism, the UMDNJ Center is also examining whether certain biochemical and genetic characteristics of autistic children, demonstrate that select children with autism have increased susceptibility to chemical induced neurobehavioral dysfunction. such as loss of neurobehavioral function may be related to exposure to environmental neurotoxins, perhaps in combination with specific genetic predispositions, creating a gene-environment interaction. With the identification of the genetic and biochemical susceptibility factors the goal will be to develop individualized therapeutic interventional strategies. The overall mission of the Center is to improve the environmental and public health of children through research, assessment, treatment and outreach.
| Identifier | Abstract | Principal Investigator |
Annual/ Final Reports |
Pubs Count | Institution | Grant Representative |
Grant Amount |
Project Period |
|
|---|---|---|---|---|---|---|---|---|---|
| 1 |
R829391
Centers - Main center abstract - Health Effects Institute (2005 — 2010) |
Center for Childhood Neurotoxicology and Assessment |
Lambert, George H. Burke, Kelly Davidovics, Zev DiCicco-Bloom, Emanuel Halladay, Alycia Lu, Shou-En Polunas, Marianne Reuhl, Kenneth R. Rossman, Ian Ruehl, Kenneth R Spencer, Stephanie Wagner, George Wilson, Daniel - Principal Investigators listed are sub-PIs determined by the center. |
Row 1: 2004
|
Row 1 Total Pubs:
122 Row 1 Journals: 85 -- Row 1: No Books -- |
University of Medicine and Dentistry of New Jersey | Hahn, Intaek | $6,751,466 |
November 01, 2001 - October 31, 2006 (Extended to October 31, 2008) |
| 2 |
R832721
Centers - Main center abstract - New Jersey Research Center for Environmental Bioinformatics and Computational Toxicology |
Environmental Bioinformatics and Computational Toxicology Center |
Welsh, William J. Androulakis, Ioannis Floudas, Christodoulos Georgopoulos, Panos G. I, Androulakis Ierapetritou, M Ierapetritou, M. Ierapetritou, Marianthi Rabitz, H Rabitz, Herschel Tong, W. Tong, Weida - Principal Investigators listed are sub-PIs determined by the center. |
Row 2: 2006
|
Row 2 Total Pubs:
302 Row 2 Journals: 111 Row 2 Books: 14 |
Rutgers, University of Medicine and Dentistry of New Jersey, Princeton University, U.S. Food and Drug Administration | Hahn, Intaek | $5,422,135 |
October 01, 2005 - September 30, 2010 |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.