Grantee Research Project Results
Publications Details for Grant Number R827445
Molecular Characterization of a Biological Threshold in Developmental Toxicity
RFA:
Children's Vulnerability to Toxic Substances in the Environment (1999)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Toxicogenomic characterization of a biological threshold in developmental toxicity. | TERATOLOGY | Charlap JH, Craig RC, O'Hara MF, Knudsen TB | Charlap JH; Craig RC; O'Hara MF; Knudsen TB. Toxicogenomic characterization of a biological threshold in developmental toxicity. Teratology 2001;63(6):281. |
R827445 (2000) R827445 (2001) |
not available |
| Abstract | Microarray analysis of gene expression in the mouse embryonic headfold following exposure to Bzrp ligands. | TERATOLOGY | Charlap JH, Nemeth KR, Craig RC, Knudsen TB | Charlap JH, Nemeth KR, Craig RC, Knudsen TB. Microarray analysis of gene expression in the mouse embryonic headfold following exposure to Bzrp ligands. Teratology 2002;65(6):333. |
R827445 (2002) R827445 (Final) |
not available |
| Abstract | Cyberteratology: investigating the physiological state of the embryo in silico. | THE TOXICOLOGIST | Knudsen TB | Knudsen TB. Cyberteratology: investigating the physiological state of the embryo in silico. Toxicologist 2003;71:113a. |
R827445 (Final) |
not available |
| Abstract | Identification of an embryonic core response signature to PK11195, an ameliorative ligand of the mitochondrial benzodiazepine receptor. | BIRTH DEFECTS RESEARCH (PART A) | Knudsen TB, Charlap JH, Nibbio B, Craig RC, Nemeth KR | Knudsen TB, Charlap JH, Nibbio B, Craig RC, Nemeth KR. Identification of an embryonic core response signature to PK11195, an ameliorative ligand of the mitochondrial benzodiazepine receptor. Birth Defects Research (Part A) 2003;67:330. |
R827445 (Final) |
not available |
| Abstract | Discovering system-level features of the early mouse embryo using mitochondrial benzodiazepine receptor ligands, microarray and computational methods. | THE TOXICOLOGIST | Knudsen TB, Singh AV | Knudsen TB, Singh AV. Discovering system-level features of the early mouse embryo using mitochondrial benzodiazepine receptor ligands, microarray and computational methods. Toxicologist. |
R827445 (Final) |
not available |
| Abstract | Microarray analysis of developmental toxicity: ontogenetic profiles of susceptibility in the mouse embryonic eye. | THE TOXICOLOGIST | Nemeth KR, Charlap JH, O'Hara MF, Craig RC, Knudsen TB | Nemeth KR, Charlap JH, O'Hara MF, Craig RC, Knudsen TB. Microarray analysis of developmental toxicity: ontogenetic profiles of susceptibility in the mouse embryonic eye. Toxicologist 2002;66:28. |
R827445 (Final) |
not available |
| Book Chapter | Microarray applications in developmental toxicology. | None | Knudsen TB, Charlap JH, Nemeth KR | Knudsen TB, Charlap JH, Nemeth KR. Microarray applications in developmental toxicology. In: Appasani K, ed. Perspectives in Gene Expression. Westboro, MA: Eaton Publishing Company/BioTechniques Press, 2003, Chapter 10, pp. 173-194. |
R827445 (2002) R827445 (Final) |
not available |
| Journal Article | Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 3. Intervention with PK11195. | BIRTH DEFECTS RESEARCH (PART A): CLINICAL AND MOLECULAR TERATOLOGY | Charlap JH, Donahue RJ, Knudsen TB | Charlap JH, Donahue RJ, Knudsen TB. Exposure-disease continuum for 2-chloro-2'-deoxyadenosine, a prototype ocular teratogen. 3. Intervention with PK11195. Birth Defects Research (Part A): Clinical and Molecular Teratology 2003;67(2):108-115. |
R827445 (2002) R827445 (Final) |
|
| Presentation | Microarray analysis of gene expression in the mouse embryonic headfold following exposure to Bzrp ligands. | None | Charlap JH, Nemeth KR, Craig RC, Knudsen TB | Charlap JH, Nemeth KR, Craig RC, Knudsen TB. Microarray analysis of gene expression in the mouse embryonic headfold following exposure to Bzrp ligands. Presented at the 42nd Annual Meeting of the Teratology Society, Scottsdale, AZ, June 22-27, 2002. |
R827445 (Final) |
not available |
| Presentation | Toxicogenomic characterization of a biological threshold in developmental toxicity. | None | Charlap JH, Craig RC, O'Hara MF, Knudsen TB | Charlap JH, Craig RC, O'Hara MF, Knudsen TB Toxicogenomic characterization of a biological threshold in developmental toxicity. Presented at the 41st Annual Meeting of the Teratology Society, Montreal, Canada, June 23-28, 2001. |
R827445 (2001) R827445 (Final) |
not available |
| Presentation | Cyberteratology: investigating the physiological state of the embryo in silico. | None | Knudsen TB | Knudsen TB. Cyberteratology: investigating the physiological state of the embryo in silico. To be presented at the Society of Toxicology Symposium, Salt Lake City, UT, March 9-13, 2003. |
R827445 (2002) R827445 (Final) |
not available |
| Presentation | Discovering system-level features of the early mouse embryo using mitochondrial benzodiazepine receptor ligands, microarray and computational methods. | None | Knudsen TB, Singh AV | Knudsen TB, Singh AV. Discovering system-level features of the early mouse embryo using mitochondrial benzodiazepine receptor ligands, microarray and computational methods. Presented at the Society of Toxicology, Annual Meeting, Baltimore, MD, March 21-25, 2004. |
R827445 (Final) |
not available |
| Presentation | Identification of an embryonic core response signature to PK11195, an ameliorative ligand of the mitochondrial benzodiazepine receptor. | None | Knudsen TB, Charlap JH, Nibbio B, Craig RC, Nemeth KR | Knudsen TB, Charlap JH, Nibbio B, Craig RC, Nemeth KR. Identification of an embryonic core response signature to PK11195, an ameliorative ligand of the mitochondrial benzodiazepine receptor. Presented at the 44th Annual Meeting of the Teratology Society, Philadelphia, PA, June 21-26, 2003. |
R827445 (Final) |
not available |
| Presentation | Microarray analysis of developmental toxicity: ontogenetic profiles of susceptibility in the mouse embryonic eye. | None | Nemeth KR, Charlap JH, O'Hara MF, Craig RC, Knudsen TB | Nemeth KR, Charlap JH, O'Hara MF, Craig RC, Knudsen TB. Microarray analysis of developmental toxicity: ontogenetic profiles of susceptibility in the mouse embryonic eye. Presented at the Annual Meeting of the Society of Toxicology, Nashville TN, March 17-21, 2002. |
R827445 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.