Grantee Research Project Results
Publications Details for Grant Number R835166
Carolina Center for Computational Toxicology: Assays, models and tools for NextGen safety assessments
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | In vitro screening for population variability in toxicity of pesticide-containing mixtures. | None | Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I | Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environment International 2015;85:147-155. |
R835166 (2016) R835166 (Final) |
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Journal Article | Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. | None | Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA | Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives 2015;123(5):458-466. |
R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | Beware of R2: simple, unambiguous assessment of the prediction accuracy of QSAR and QSPR models. | None | Alexander DL, Tropsha A, Winkler DA | Alexander DL, Tropsha A, Winkler DA. Beware of R2: simple, unambiguous assessment of the prediction accuracy of QSAR and QSPR models. Journal of Chemical Information and Modeling 2015 Jul 27;55(7):1316-1322. |
R835166 (Final) |
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Journal Article | Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. | None | Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer N, Andrade CH, Tropsha A | Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer N, Andrade CH, Tropsha A. Predicting chemically-induced skin reactions. Part I: QSAR models of skin sensitization and their application to identify potentially hazardous compounds. Toxicology and Applied Pharmacology 2015;284(2):262-272. |
R833825 (Final) R835166 (Final) |
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Journal Article | Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization. | None | Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer N, Andrade CH, Tropsha A | Alves VM, Muratov E, Fourches D, Strickland J, Kleinstreuer N, Andrade CH, Tropsha A. Predicting chemically-induced skin reactions. Part II: QSAR models of skin permeability and the relationships between skin permeability and skin sensitization. Toxicology and Applied Pharmacology 2015; 284(2):273-280. |
R833825 (Final) R835166 (Final) |
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Journal Article | Alarms about structural alerts. | None | Alves V, Muratov E, Capuzzi S, Politi R, Low Y, Braga R, Zakharov AV, Sedykh A, Mokshyna E, Farag S, Andrade C, Kuz'min V, Fourches D, Tropsha A | Alves V, Muratov E, Capuzzi S, Politi R, Low Y, Braga R, Zakharov AV, Sedykh A, Mokshyna E, Farag S, Andrade C, Kuz'min V, Fourches D, Tropsha A. Alarms about structural alerts. Green Chemistry 2016;18(16):4348-4360. |
R835166 (Final) |
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Journal Article | Chemical safety assessment using read-across: assessing the use of novel testing methods to strengthen the evidence base for decision making. | None | Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Schuurmann G, White A, Burton J, Lostia AM, Munn S, Worth A | Berggren E, Amcoff P, Benigni R, Blackburn K, Carney E, Cronin M, Deluyker H, Gautier F, Judson RS, Kass GE, Keller D, Knight D, Lilienblum W, Mahony C, Rusyn I, Schultz T, Schwarz M, Schuurmann G, White A, Burton J, Lostia AM, Munn S, Worth A. Chemical safety assessment using read-across: assessing the use of novel testing methods to strengthen the evidence base for decision making. Environmental Health Perspectives 2015;123(12):1232-1240. |
R835166 (2016) R835166 (Final) |
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Journal Article | Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: a systematic literature review. | None | Chappell G, Pogribny IP, Guyton KZ, Rusyn I | Chappell G, Pogribny IP, Guyton KZ, Rusyn I. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: a systematic literature review. Mutation Research. Reviews in Mutation Research 2016;768:27-45. |
R835166 (Final) |
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Journal Article | A tiered, Bayesian approach to estimating population variability for regulatory decision-making. | None | Chiu WA, Wright FA, Rusyn I | Chiu WA, Wright FA, Rusyn I. A tiered, Bayesian approach to estimating population variability for regulatory decision-making. ALTEX 2017;34(3):377-388. |
R835166 (2016) R835166 (Final) R835802 (2016) R835802 (2017) R835802 (2018) |
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Journal Article | The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. | None | Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWos | Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. Environmental Health Perspectives 2016;124(11):1671-1682. |
R835166 (Final) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Journal Article | Prediction of human population responses to toxic compounds by a collaborative competition. | None | Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J | Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, Kosyk O, NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration, Friend S, Dearry A, Simeonov A, Tice RR, Rusyn I, Wright FA, Stolovitzky G, Xie Y, Saez-Rodriguez J. Prediction of human population responses to toxic compounds by a collaborative competition. Nature Biotechnology 2015;33(9):933-940. |
R835166 (2016) R835166 (Final) |
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Journal Article | Using graph indices for the analysis and comparison of chemical datasets. | None | Fourches D, Tropsha A | Fourches D, Tropsha A. Using graph indices for the analysis. Using graph indices for the analysis and comparison of chemial datasets. Molecular Informatics 2013;32(9-10):827-842. |
R835166 (Final) |
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Journal Article | Curation of chemogenomics data. | None | Fourches D, Muratov E, Tropsha A | Fourches D, Muratov E, Tropsha A. Curation of chemogenomics data. Nature Chemical Biology 2015;11(8):535. |
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Journal Article | Trust, but verify II: a practical guide to chemogenomics data curation. | None | Fourches D, Muratov E, Tropsha A | Fourches D, Muratov E, Tropsha A. Trust, but verify II: a practical guide to chemogenomics data curation. Journal of Chemical Information and Modeling 2016;56(7):1243-1252. |
R835166 (Final) |
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Journal Article | A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. | GREEN CHEMISTRY | Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chemistry 2016;18(16):4407-4419. |
R835166 (Final) R835802 (2015) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
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Journal Article | Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. | None | Grimm FA, Russell WK, Luo YS, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I | Grimm FA, Russell WK, Luo YS, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I. Grouping of petroleum substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across. Environmental Science and Technology 2017;51(12):7197-7207. |
R835166 (Final) |
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Journal Article | Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. | REGULATORY TOXICOLOGY AND PHARMACOLOGY | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N,Rusyn I | Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. Regulatory Toxicology and Pharmacology 2019;101:91-102. |
R835166 (Final) R835802 (2018) R835802C001 (2018) |
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Journal Article | High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells | None | Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I | Iwata Y, Klaren WD, Lebakken CS, Grimm FA, Rusyn I. High-content assay multiplexing for vascular toxicity screening in induced pluripotent stem cell-derived endothelial cells and human umbilical vein endothelial cells. Assay and Drug Development Technologies 2017;15(6):267-279. |
R835166 (Final) R835802 (2017) R835802 (2018) |
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Journal Article | A systematic approach for identifying and presenting mechanistic evidence in human health assessments. | None | Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I | Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I. A systematic approach for identifying and presenting mechanistic evidence in human health assessments. Regulatory Toxicology and Pharmacology 2013;67(2):266-277. |
R835166 (Final) |
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Journal Article | From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods. | None | Linkov I, Massey O, Keisler J, Rusyn I, Hartung T | Linkov I, Massey O, Keisler J, Rusyn I, Hartung T. From "weight of evidence" to quantitative data integration using multicriteria decision analysis and Bayesian methods. ALTEX 2015;32(1):3-8. |
R835166 (Final) |
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Journal Article | Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. | None | Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I | Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences 2012;126(2):578-588. |
R833825 (Final) R835166 (Final) |
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Journal Article | Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. | None | Low YS, Sedykh AY, Rusyn I, Tropsha A | Low YS, Sedykh AY, Rusyn I, Tropsha A. Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. Current Topics in Medicinal Chemistry 2014;14(11):1356-1364. |
R832720 (2009) R833825 (Final) R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | Integrative chemical-biological read-across approach for chemical hazard classification. | None | Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A | Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. Integrative chemical-biological read-across approach for chemical hazard classification. Chemical Research in Toxicology 2013;26(8):1199-1208. |
R835166 (2013) R835166 (2016) R835166 (Final) |
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Journal Article | Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol | None | Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W | Lu E, Grimm F, Rusyn I, De Saeger S, De Bouvre M, Chiu W. Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling:A case study with the mycotoxin deoxynivalenol. ENVIRONMENT INTERNATIONAL 2023;182(108326). |
R835166 (Final) R835802 (Final) |
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Journal Article | CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. | ENVIRONMENTAL HEALTH PERSPECTIVES | Mansouri K, Abdelaziz A, Rybacka A, Roncaglioni A, Tropsha A, Varnek A, Zakharov A, Worth A, Richard AM, Grulke CM, Trisciuzzi D, Fourches D, Horvath D, Benfenati E, Muratov E, Wedebye EB, Grisoni F, Mangiatordi GF, Incisivo GM, Hong H, Ng HW, Tetko IV, Balabin I, Kancherla J, Shen J, Burton J, Nicklaus M, Cassotti M, Nikolov NG, Nicolotti O, Andersson PL, Zang Q, Politi R, Beger RD, Todeschini R, Huang R, Farag S, Rosenberg SA, Slavov S, Hu X, Judson RS | Mansouri K, Abdelaziz A, Rybacka A, Roncaglioni A, Tropsha A, Varnek A, Zakharov A, Worth A, Richard AM, Grulke CM, Trisciuzzi D, Fourches D, Horvath D, Benfenati E, Muratov E, Wedebye EB, Grisoni F, Mangiatordi GF, Incisivo GM, Hong H, Ng HW, Tetko IV, Balabin I, Kancherla J, Shen J, Burton J, Nicklaus M, Cassotti M, Nikolov NG, Nicolotti O, Andersson PL, Zang Q, Politi R, Beger RD, Todeschini R, Huang R, Farag S, Rosenberg SA, Slavov S, Hu X, Judson RS. CERAPP: Collaborative Estrogen Receptor Activity Prediction Project. Environmental Health Perspectives 2016;124(7):1023-1033. |
R835166 (2016) R835166 (Final) |
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Journal Article | Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods. | TOXICOLOGY AND APPLIED PHARMACOLOGY | Politi R, Rusyn I, Tropsha A | Politi R, Rusyn I, Tropsha A. Prediction of binding affinity and efficacy of thyroid hormone receptor ligands using QSAR and structure-based modeling methods. Toxicology and Applied Pharmacology 2014;280(1):177-189. |
R833825 (Final) R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. | None | Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I | Reif DM, Sypa M, Lock EF, Wright FA, Wilson A, Cathey T, Judson RR, Rusyn I. ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. Bioinformatics 2013;29(3):402-403. |
R835166 (Final) |
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Journal Article | Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data. | None | Rusyn I, Sedykh A, Low Y, Guyton KZ, Tropsha A | Rusyn I, Sedykh A, Low Y, Guyton KZ, Tropsha A. Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data. Toxicological Sciences 2012;127(1):1-9. |
R833825 (Final) R835166 (Final) |
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Journal Article | Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? | None | Rusyn I, Lemon SM | Rusyn I, Lemon SM. Mechanisms of HCV-induced liver cancer: what did we learn from in vitro and animal studies? Cancer Letters 2014;345(2):210-215. |
R835166 (2014) R835166 (2016) |
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Journal Article | Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. | None | Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I | Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I. Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicology and Applied Pharmacology 2013;273(3):500-507. |
R835166 (2013) R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. | JOURNAL OF BIOMOLECULAR SCREENING | Sirenko O, Crittenden C, Callamaras N, Hesley J, Chen YW, Funes C, Rusyn I, Anson B, Cromwell EF | Sirenko O, Crittenden C, Callamaras N, Hesley J, Chen YW, Funes C, Rusyn I, Anson B, Cromwell EF. Multiparameter in vitro assessment of compound effects on cardiomyocyte physiology using iPSC cells. Journal of Biomolecular Screening 2013;18(1):39-53. |
R835166 (2013) R835166 (2016) R835166 (Final) |
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Journal Article | High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. | ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES | Sirenko O, Hesley J, Rusyn I, Cromwell EF | Sirenko O, Hesley J, Rusyn I, Cromwell EF. High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. Assay and Drug Development Technologies 2014;12(1):43-54. |
R835166 (2013) R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures. | None | Sirenko O, Hesley J, Rusyn I, Cromwell EF | Sirenko O, Hesley J, Rusyn I, Cromwell E. High-content high-throughput assays for characterizing the viability and morphology of human iPSC-derived neuronal cultures. Assay and Drug Development Technologies 2014;12(9-10):536-547. |
R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. | None | Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR | Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicology and Applied Pharmacology 2017;322:60-74. |
R835166 (Final) R835802 (2016) R835802 (2017) R835802 (2018) |
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Journal Article | Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. | None | Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K | Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K. Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environmental Health Perspectives 2016;124(6):713-721. |
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Journal Article | Toxicokinetic triage for environmental chemicals. | TOXICOLOGICAL SCIENCES | Wambaugh JF, Wetmore BA, Pearce R, Strope C, Goldsmith R, Sluka JP, Sedykh A, Tropsha A, Bosgra S, Shah I, Judson R, Thomas RS, Setzer RW | Wambaugh JF, Wetmore BA, Pearce R, Strope C, Goldsmith R, Sluka JP, Sedykh A, Tropsha A, Bosgra S, Shah I, Judson R, Thomas RS, Setzer RW. Toxicokinetic triage for environmental chemicals. Toxicological Sciences 2015;147(1):55-67. |
R835001 (Final) R835166 (2016) R835166 (Final) |
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Journal Article | Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. | None | Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I | Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I. Standardizing benchmark dose calculations to improve science-based decisions in human health assessments. Environmental Health Perspectives 2014;122(5):499-505. |
R835166 (2013) R835166 (2014) R835166 (2016) R835166 (Final) |
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Journal Article | Computational tools for discovery and interpretation of expression quantitative trait loci. | None | Wright FA, Shabalin AA, Rusyn I | Wright FA, Shabalin AA, Rusyn I. Computational tools for discovery and interpretation of expression quantitative trait loci. Pharmacogenomics 2012;13(3):343-352. |
R833825 (Final) R835166 (Final) |
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Journal Article | Addressing human variability in next-generation human health risk assessments of environmental chemicals. | None | Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ | Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ. Addressing human variability in next-generation human health risk assessments of environmental chemicals. Environmental Health Perspectives 2013;121(1):23-31. |
R835166 (Final) |
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Journal Article | Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. | None | Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A | Zhang L, Sedykh A, Tripathi A, Zhu H, Afantitis A, Mouchlis VD, Melagraki G, Rusyn I, Tropsha A. Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches. Toxicology and Applied Pharmacology 2013;272(1):67-76. |
R833825 (Final) R835166 (2013) R835166 (Final) |
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Presentation | The 1000 genomes toxicity screening project: utilizing the power of human genome variation for population-scale in vitro testing. | None | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Austin C | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Austin C. The 1000 genomes toxicity screening project: utilizing the power of human genome variation for population-scale in vitro testing. Presented at the Society of Toxicology (SOT) Annual Meeting and ToxExpo, San Francisco, CA, March 11-15, 2012. |
R835166 (2013) R835166 (Final) |
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Presentation | The 1000 genomes toxicity screening project: utilizing the power of human genome variation for population-scale in vitro testing. | None | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C. The 1000 genomes toxicity screening project: utilizing the power of human genome variation for population-scale in vitro testing. Presented at the Society of Toxicology (SOT) Annual Meeting and ToxExpo, San Antonio, TX, March 10-14, 2013. |
R833825 (Final) R835166 (2013) |
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Presentation | The 1000 genomes toxicity screening project:utilizing the power of human genome variation for population scale in vitro testing. | None | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C | Abdo N, Xia M, Kosyk O, Huang R, Sakamuru S, Brown C. The 1000 genomes toxicity screening project:utilizing the power of human genome variation for population scale in vitro testing. Presented at the Society of Toxicology 52nd Annual Meeting & ToxExpo™, San Antonio, TX, March 10-14, 2013. |
R835166 (Final) |
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Presentation | Utilizing human population-based in vitro model to investigate pesticide mixtures and drug/metabolite pairs. | None | Abdo N, Marlot P, Pirmohamed M, Shea D, Wright FA, Rusyn I | Abdo N, Marlot P, Pirmohamed M, Shea D, Wright FA, Rusyn I. Utilizing human population-based in vitro model to investigate pesticide mixtures and drug/metabolite pairs. Presented at the Society of Toxicology (SOT) Annual Meeting and ToxExpo, Phoenix, AZ, March 23-27, 2014. |
R835166 (2013) R835166 (Final) |
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Presentation | The importance of chemical data curation to achieve accurate prediction of ER binding affinity for environmental chemicals. | None | Farag S, Muratov E, Fourches D, Tropsha A | Farag S, Muratov E, Fourches D, Tropsha A. The importance of chemical data curation to achieve accurate prediction of ER binding affinity for environmental chemicals. Presented at the U.S. EPA Chemical Safety Research: Second ToxCast Data Summit, Research Triangle Park, NC, September 29-30, 2014 (Abstract no. 43). |
R835166 (2014) R835166 (Final) |
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Presentation | Toxicological categorization of petroleum substances through high-content screening of induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes. | None | Grimm FA, Iwata Y, Sirenko O, Crittenden C, Roy T, Boogaard P, Ketelslegers H, Rohde A, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Crittenden C, Roy T, Boogaard P, Ketelslegers H, Rohde A, Rusyn I. Toxicological categorization of petroleum substances through high-content screening of induced pluripotent stem cell (iPSC) derived cardiomyocytes and hepatocytes. Presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835166 (2014) R835166 (Final) |
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Presentation | Categorization of UVCBs using chemical-biological read across. | None | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I | Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I. Categorization of UVCBs using chemical-biological read across. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2016) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
Presentation | Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I | Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I. Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (2016) R835802 (2016) R835802 (2017) R835802 (2018) R835802C001 (2015) |
not available |
Presentation | Categorization of UVCBs using chemical-biological read across. | None | Rusyn I | Rusyn I. Categorization of UVCBs using chemical-biological read across. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (Final) R835802 (2016) R835802 (2017) R835802 (2018) |
not available |
Presentation | Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. | None | Rusyn I | Rusyn I. Toxicological categorization of p-and e-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835166 (Final) R835802 (2017) R835802 (2018) |
not available |
Presentation | Web-based benchmark dose modeling module as a prototype component of an informatics-based system for human health assessments of chemicals. | None | Shapiro AJ, Cook N, Ross PK, Fox J, Cogliano V, Chiu WA | Shapiro AJ, Cook N, Ross PK, Fox J, Cogliano V, Chiu WA. Web-based benchmark dose modeling module as a prototype component of an informatics-based system for human health assessments of chemicals. Presented at the Society of Toxicology (SOT) Annual Meeting and ToxExpo, San Antonio, TX, March 10-14, 2013. |
R835166 (2013) R835166 (Final) |
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Presentation | Conditional Toxicity Value (CTV) predictor for generating toxicity values for data-sparse chemicals. | None | Wignall JA, Muratov E, Fourches D, Tropsha A, Woodruff T, Zeise L | Wignall JA, Muratov E, Fourches D, Tropsha A, Woodruff T, Zeise L. Conditional Toxicity Value (CTV) predictor for generating toxicity values for data-sparse chemicals. Presented at the Society of Toxicology (SOT) Annual Meeting and ToxExpo, San Antonio, TX, March 10-14, 2013. |
R835166 (2013) R835166 (Final) |
not available |
Presentation | Data integration and visualization for transparent communication of the category read across using ToxPi (Toxicological Priority Index) tool: P-series glycol ethers case study. | None | Wilson MR, Ball N, Carney EW, Rowlands JC, Rusyn I | Wilson MR, Ball N, Carney EW, Rowlands JC, Rusyn I. Data integration and visualization for transparent communication of the category read across using ToxPi (Toxicological Priority Index) tool: P-series glycol ethers case study. Presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835166 (2014) R835166 (Final) |
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Presentation | A cost effective targeted sequencing method for monitoring gene expression. | None | Yeakley J, Abdo N, Chappell G, Shepard P, Rusyn I, Seligmann B | Yeakley J, Abdo N, Chappell G, Shepard P, Rusyn I, Seligmann B. A cost effective targeted sequencing method for monitoring gene expression. Presented at the Society of Toxicology (SOT) 54th Annual Meeting and ToxExpo, San Diego, CA, March 22-26, 2015. |
R835166 (2014) R835166 (Final) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.