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Grantee Research Project Results

Publications Details for Grant Number R834799C001

Development and Deployment of an Instrumentation Suite for Comprehensive Air Quality Characterization Including Aerosol ROS

RFA: Clean Air Research Centers (2009)

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Journal Article (17)
Presentation (45)
Reference Type Citation Progress Report Year Document Sources
Journal Article Bates JT, Weber RJ, Abrams J, Verma V, Fang T, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG. Reactive oxygen species generation linked to sources of atmospheric particulate matter and cardiorespiratory effects. Environmental Science & Technology 2015;49(22):13605-13612. R834799 (2015)
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Journal Article Budisulistiorini SH, Canagaratna MR, Croteau PL, Baumann K, Edgerton ES, Kollman MS, Ng NL, Verma V, Shaw SL, Knipping EM, Worsnop DR, Jayne JT, Weber RJ, Surratt JD. Intercomparison of an Aerosol Chemical Speciation Monitor (ACSM) with ambient fine aerosol measurements in downtown Atlanta, Georgia. Atmospheric Measurement Techniques 2014;7(7):1929-1941. R834799 (2015)
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Journal Article Fang T, Verma V, Guo H, King LE, Edgerton ES, Weber RJ. A semi-automated system for quantifying the oxidative potential of ambient particles in aqueous extracts using the dithiothreitol (DTT) assay: results from the Southeastern Center for Air Pollution and Epidemiology (SCAPE). Atmospheric Measurement Techniques 2015;8(1):471-482. R834799 (2015)
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Journal Article Fang T, Guo H, Verma V, Peltier RE, Weber RJ. PM2.5 water-soluble elements in the southeastern United States: automated analytical method development, spatiotemporal distributions, source apportionment, and implications for heath studies. Atmospheric Chemistry and Physics 2015;15(20):11667-11682. R834799 (2015)
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Journal Article Fang T, Verma V, Bates JT, Abrams J, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG, Weber RJ. Oxidative potential of ambient water-soluble PM2.5 in the southeastern United States: contrasts in sources and health associations between ascorbic acid (AA) and dithiothreitol (DTT) assays. Atmospheric Chemistry and Physics 2016;16(6):3865-3879. R834799 (2015)
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Journal Article Guo H, Xu L, Bougiatioti A, Cerully KM, Capps SL, Hite Jr. JR, Carlton AG, Lee S-H, Bergin MH, Ng NL, Nenes A, Weber RJ. Fine-particle water and pH in the southeastern United States. Atmospheric Chemistry and Physics 2015;15(9):5211-5228. R834799 (2015)
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Journal Article King LE, Weber RJ. Development and testing of an online method to measure ambient fine particulate Reactive Oxygen Species (ROS) based on the 2’,7’-dichlorofluorescin (DCFH) assay. Atmospheric Measurement Techniques 2013;6(7):1647-1658. R834799 (2013)
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Journal Article Liu J, Bergin M, Guo H, King L, Kotra N, Edgerton E, Weber RJ. Size-resolved measurements of brown carbon in water and methanol extracts and estimates of their contribution to ambient fine-particle light absorption. Atmospheric Chemistry and Physics 2013;13(24):12389-12404. R834799 (2014)
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Journal Article Liu J, Scheuer E, Dibb J, Ziemba LD, Thornhill KL, Anderson BE, Wisthaler A, Mikoviny T, Devi JJ, Bergin M, Weber RJ. Brown carbon in the continental troposphere. Geophysical Research Letters 2014;41(6):2191-2195. R834799 (2014)
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Journal Article Sarnat SE, Chang HH, Weber RJ. Ambient PM2.5 and health: does PM2.5 oxidative potential play a role? American Journal of Respiratory and Critical Care Medicine 2016;194(5):530-531. R834799 (2016)
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Journal Article Verma V, Rico-Martinez R, Kotra N, King L, Liu J, Snell TW, Weber RJ. Contribution of water-soluble and insoluble components and their hydrophobic/hydrophilic subfractions to the reactive oxygen species-generating potential of fine ambient aerosols. Environmental Science & Technology 2012;46(20):11384-11392. R834799 (2012)
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Journal Article Verma V, Rico-Martinez R, Kotra N, Rennolds C, Liu J, Snell TW, Weber RJ. Estimating the toxicity of ambient fine aerosols using freshwater rotifer Brachionus calyciflorus (Rotifera: Monogononta). Environmental Pollution 2013;182:379-384. R834799 (2014)
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Journal Article Verma V, Fang T, Guo H, King L, Bates JT, Peltier RE, Edgerton E, Russell AG, Weber RJ. Reactive oxygen species associated with water-soluble PM2.5 in the southeastern United States: spatiotemporal trends and source apportionment. Atmospheric Chemistry and Physics 2014;14(23):12915-12930. R834799 (2015)
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Journal Article Verma V, Fang T, Xu L, Peltier RE, Russell AG, Ng NL, Weber RJ. Organic aerosols associated with the generation of reactive oxygen species (ROS) by water-soluble PM2.5. Environmental Science & Technology 2015;49(7):4646-4656. R834799 (2015)
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Journal Article Verma V, Wang Y, El-Afifi R, Fang T, Rowland J, Russell AG, Weber RJ. Fractionating ambient humic-like substances (HULIS) for their reactive oxygen species activity—assessing the importance of quinones and atmospheric aging. Atmospheric Environment 2015;120:351-359. R834799 (2015)
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Journal Article Weber RJ, Guo H, Russell AG, Nenes A. High aerosol acidity despite declining atmospheric sulfate concentrations over the past 15 years. Nature Geoscience 2016;9:282-285. R834799 (2016)
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Journal Article Xu L, Guo H, Boyd CM, Klein M, Bougiatioti A, Cerully KM, Hite JR, Isaacman-VanWertz G, Kreisberg NM, Knote C, Olson K, Koss A, Goldstein AH, Hering SV, de Gouw JA, Baumann K, Lee S-H, Nenes A, Weber RJ, Ng NL. Effects of anthropogenic emissions on aerosol formation from isoprene and monoterpenes in the southeastern United States. Proceedings of the National Academy of Sciences of the United States of America 2015;112(1):37-42. R834799 (2015)
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Presentation Abrams JY, Bates JT, Klein M, Weber RJ, Russell AG, Mulholland JA, Sarnat SE, Chang HH, Tolbert PE. Modeling approaches linking acute health outcomes and reactive oxygen species-generating potential of ambient particulate matter. Poster presented at the International Society for Environmental Epidemiology (ISEE) Annual Meeting, Rome, Italy, September 1-4, 2016. R834799 (2016)
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Presentation Bates JT, Weber R, Abrams J, Verma V, Fang T, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG. Deconvoluting mixtures of emissions sources to investigate PM2.5’s ability to generate reactive oxygen species and its associations with cardiorespiratory effects. Poster presented at the American Geophysical Union (AGU) Conference, San Francisco, CA, December 14-18, 2015. R834799 (2016)
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Presentation Bates JT, Weber RJ, Abrams J, Verma V, Fang T, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG. Source impacts on reactive oxygen species generated by water-soluble PM2.5 in Atlanta and associations with cardiorespiratory effects. Presented at the American Association for Aerosol Research (AAAR) Annual Conference, Minneapolis, MN, October 12-16, 2015. R834799 (2015)
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Presentation Bates JT, Weber R, Abrams J, Verma V, Fang T, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG. Reactive oxygen species generation linked to sources of atmospheric particulate matter and cardiorespiratory effects. Poster presented at the 14th Annual Community Modeling and Analysis System (CMAS) Conference, Chapel Hill, NC, October 5-7, 2015. R834799 (2016)
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Presentation Bates JT, Weber R, Abrams J, Verma V, Fang T, Ivey C, Liu C, Klein M, Strickland MJ, Sarnat SE, Chang HH, Mulholland JA, Tolbert PE, Russell AG. Source impacts on and cardiorespiratory effects of reactive oxygen species generated by water-soluble PM2.5 across the Eastern United States. Presented at the International Technical Meeting on Air Pollution Modeling and its Applications Conference, Chania, Crete, Greece, October 3-7, 2016. R834799 (2016)
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Presentation Bates J, Abrams J, Tolbert P, Gass K, Klein M, Verma V, Weber R, Mulholland J, Russell A. Sources and health effects of reactive oxygen species in Atlanta air pollution. Poster presented at the 9th Annual Georgia Environmental Conference, Jekyll Island, GA, August 20-22, 2014. R834799 (2014)
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Presentation Bates J, Weber RJ, Fang T, Mulholland JA, Russell A, Abrams J, Klein M, Strickland MJ, Sarnat SE, Chang HH, Tolbert PE, Verma V. Sources of PM2.5 with high oxidative potential linked to health effects. Presented at the Air and Waste Management Association 109th Annual Conference and Exhibition, New Orleans, LA, June 20-23, 2016. R834799 (2016)
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Presentation Fang T, Verma V, Weber RJ. Semi-automated system for measuring oxidative potential of ambient particles collected on filters using dithiothreitol (DTT) assay. Poster presented at the 32nd Annual Conference of the American Association for Aerosol Research, Portland, OR, September 30-October 4, 2013. R834799 (2013)
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Presentation Fang T, Verma V, Peltier RE, Guo H, King LE, Weber RJ. Distribution of ambient atmospheric water-soluble metals in the southeastern United States and insights into their complexation states. Poster presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
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Presentation Fang T, Verma V, Weber RJ. Online determination of aerosol oxidative potential with particle-into-liquid sampler (PILS) using DTT (Dithiothreitol) assay. Poster presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
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Presentation Fang T, Verma V, Bates JT, Mulholland JA, Russell AG, Weber RJ. Contrasting oxidative potential of ambient water-soluble PM2.5 measured by dithiothreitol (DTT) and ascorbic acid (AA) assays: spatiotemporal distribution, source apportionment, and health impacts. Poster presented at the American Association for Aerosol Research (AAAR) Annual Conference, Minneapolis, MN, October 12-16, 2015. R834799 (2015)
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Presentation Gao D, Fang T, Verma V, Weber RJ. Artifacts and stability of fine particle oxidative potential determined with dithiothreitol (DTT) assay on filter extracts. Poster presented at the American Association for Aerosol Research (AAAR) Annual Conference, Minneapolis, MN, October 12-16, 2015. R834799 (2016)
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Presentation Guo H, Xu L, Bougiatioti A, Cerully KM, Capps SL, Hite JR, Carlton AG, Lee S, Bergin MH, Ng NL, Nenes A, Weber RJ. Particle water and pH in the southeastern United States. Presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
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Presentation King L, Verma V, Weber R. Refinement and testing of a fluorometric assay for continuous online ROS measurement and results from preliminary field deployments. Presented at the 30th Annual American Association for Aerosol Research Conference, Orlando, FL, October 3-7, 2011. R834799 (2011)
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Presentation King L, Verma V, Weber RJ. Semi-continuous online measurements of reactive oxygen species in the particle and gas phase. Presented at the 31st Annual American Association for Aerosol Research Conference, Minneapolis, MN, October 8-12, 2012. R834799 (2013)
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Presentation King L, Guo H, Fang T, Verma V, Edgerton E, Russell A, Weber R. The Southeastern Center for Air Pollution and Epidemiology: preliminary results from the measurement campaign. Poster presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
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Presentation Kotra N, King L, Weber RJ. Optimization of ROS measurement with Amplex Red. Presented at the 30th Annual American Association for Aerosol Research Conference, Orlando, FL, October 3-7, 2011. R834799 (2012)
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Presentation Kotra N, King L, Weber RJ. Development and testing of a continuous Amplex Red method for measuring particle-bound ROS. Presented at the 30th Annual American Association for Aerosol Research Conference, Orlando, FL, October 3-7, 2011. R834799 (2014)
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Presentation Kotra N, Verma V, Liu J, Surratt JD, Edgerton E, Ng NL, Weber RJ. Performance evaluation of a recently developed Aerosol Chemical Speciation Monitor (ACSM). Poster presented at the 31st Annual American Association for Aerosol Research Conference, Minneapolis, MN, October 8-12, 2012. R834799 (2013)
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Presentation Lu X, Guo H, King L, Verma V, Weber R, Ng NL. A study of secondary organic aerosol formation influenced by mixed anthropogenic and biogenic emissions in Atlanta area by high resolution mass spectrometer. Presented at the 32nd Annual American Association for Aerosol Research Conference, Portland, OR, September 30-October 4, 2013. R834799 (2013)
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Presentation Nenes A, Guo H, Russell AG, Weber RJ. Aerosol pH buffering in the southeastern US: fine particles remain highly acidic despite large reductions in sulfate. Presented at the American Association for Aerosol Research (AAAR) Annual Conference, Minneapolis, MN, October 12-16, 2015 (platform). R834799 (2016)
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Presentation Ng NL, Xu L, Suresh S, Weber RJ, Baumann K, Edgerton ES. Characterization of aerosol composition and sources in the greater Atlanta area by aerosol mass spectrometry. Poster presented at the American Geophysical Union (AGU) 47th Annual Fall Meeting, San Francisco, CA, December 15-19, 2014. R834799 (2015)
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Presentation Ng NL, Tuet WY, Verma V, Weber RJ, Champion JA, Knight MB, Grosberg A. Laboratory chamber and field study characterization of the composition and oxidative properties of particulate matter mixtures: effects of particle phase state, acidity, and transition metals. Poster presented at the Health Effects Institute (HEI) Annual Conference, Alexandria, VA, May 4-6, 2014. R834799 (2014)
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Presentation Ng NL, Kollman M, Papapostolou V, Lawrence J, Suresh S, Verma V, Jayne J, Croteau P, Weber R, Russell A, Koutrakis P. Investigating the health effects of fresh and aged traffic aerosols: linking particle oxidative potential to chemical composition. Presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
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Presentation Ng NL, Xu L, King L, Guo HY, Verma V, Kotra N, Weber RJ. Aerosol composition and sources in the Atlanta area measured by high resolution mass spectrometry. Presented at the American Institute of Chemical Engineers (AlChE) Annual Meeting, Pittsburgh PA, October 28-November 2, 2012. R834799 (2016)
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Presentation Tuet W-Y, Verma V, Champion J, Ng NL. Composition and oxidative properties of particulate matter (PM) mixtures. Presented at the American Institute of Chemical Engineers (AIChE) Conference, Atlanta, GA, November 16-21, 2014. R834799 (2015)
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Presentation Verma V, Kotra N, King L, Liu J, Rico-Martinez R, Snell TW, Weber RJ. Comparative analysis of the contribution of water-soluble and insoluble PM components in the toxicological properties of ambient atmospheric aerosols. Presented at the 31st Annual American Association for Aerosol Research Conference, Minneapolis, MN, October 8-12, 2012. R834799 (2013)
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Presentation Verma V, Rico-Martinez R, Kotra N, King L, Liu J, Snell TW, Weber RJ. Contribution of water-soluble and insoluble species and their hydrophobic/hydrophilic sub-fractions in the toxicological properties of ambient atmospheric aerosols. Poster presented at the International Global Atmospheric Chemistry Open Science Conference, Beijing, China, September 17-21, 2012. R834799 (2013)
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Presentation Verma V, Fang T, Weber RJ. Contrasting profiles of the oxidative properties of ambient aerosols collected from urban and rural environments in Atlanta. Presented at the 32nd Annual American Association for Aerosol Research Conference, Portland, OR, September 30-October 4, 2013. R834799 (2013)
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Presentation Verma V, Fang T, Bates J, Lu X, Ng NL, Russell AG, Weber RJ. Biomass burning as an important source of reactive oxygen species associated with the atmospheric aerosols in southeastern United States – implications for health effects of ambient particulate matter. Poster presented at the American Geophysical Union (AGU) 47th Annual Fall Meeting, San Francisco, CA, December 15-19, 2014. R834799 (2015)
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Presentation Verma V, Wang Y, Rawan El-Afifi, Fang T, Rowland JR, Russell AG, Weber RJ. On the contribution of atmospheric quinones to reactive oxygen species associated with watersoluble PM2.5. Poster presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Verma V, Fang T, Xu L, Peltier RE, Russell AG, Ng NL, Weber RJ. Organic aerosols associated with ROS generation. Presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Verma V, Fang T, Guo H, King L, Bates JT, Peltier RE, Edgerton E, Russell AG, Weber RJ. Reactive oxygen species associated with water-soluble PM2.5 in the southeastern United States:spatiotemporal trends and source apportionment. Presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Verma V, Fang T, Bates JT, Russell AG, Weber RJ. Oxidative potential of ambient particulate matter in southeastern United States and the generation of reactive oxygen species. Poster presented at the Society of Environmental Toxicology and Chemistry (SETAC) North America 36th Annual Meeting, Salt Lake City, UT, November 1-5, 2015. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Verma V, Fang T, Bates JT, Russell AJ, Devlin R, Weber RJ. Reactive oxygen species (ROS) associated with ambient particulate matter – insights from Southeastern Center for Air Pollution and Epidemiology (SCAPE) study. Presented at the 34th Annual American Association for Aerosol Research (AAAR) Conference, Minneapolis, MN, October 12-16, 2015 (platform). R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Verma V, Fang T, Xu L, Gao H, Bates JT, Russell AG, Peltier R, Lee N, Weber RJ. Reactive oxygen species associated with water-soluble PM2.5 in the southeastern United States – implications for health effects of ambient atmospheric aerosols. Presented the International Society for Exposure Science (ISES) Annual Meeting, Henderson, NV, October 18-22, 2015 (platform). R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Walker M, Williams B, Martinez R, Zhang Y, Mitroo D, Hagan D, Dhawan S, Du L, Turner J, Guo H, King L, Weber R, Hu L, Baasandorj M, Millet D, McMeeking G. Instrument intercomparison of black carbon measurements and correlations with gas and aerosol composition during an urban field study. Presented at the American Association for Aerosol Research (AAAR) 33rd Annual Conference, Orlando FL, October 20-24, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
R835402 (2014)
R835402 (Final)
  • Other: AAAR-Conference Program
    Exit
Presentation Weber RJ, Liu J, Bergin M, Edgerton ES, Guo H, King LE. Size-resolved measurements of brown carbon for estimating contributions to fine particle light absorption. Poster presented at the American Geophysical Union Fall Meeting, San Francisco, CA, December 9-13, 2013. R834799 (2014)
R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Weber RJ, Guo H, Russell AG, Nenes A. Aerosol pH buffering in the southeastern US:fine particles remain highly acidic despite large reductions in sulfate. Presented at the American Geophysical Union (AGU) Fall Meeting, San Francisco, CA, December 14-18, 2015. R834799 (2016)
R834799 (Final)
R834799C001 (Final)
not available
Presentation Weber R, Ng NL, Nenes A, Bergin M, Xu L, Guo H, Cerully K, Bougiatioti A, King L, Agostini G, Lin J, Fang T, Verma V, McKenzie M, Jeryraman J, Carlton A, Nguyen TK, Petters M, Suda A, Edgerton E. Fine particle water-soluble organic carbon over the southeastern United States. Presented at the American Geophysical Union Fall Meeting, San Francisco, CA, December 9-13, 2013. R834799 (2014)
R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2014)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Weber R, Liu J, Bergin M, Jai Devi J, Scheuer E, Dibb J, Anderson BE, Thornhill KL, Schwartz J, Gao R. Recent studies on the sources, prevalence and optical importance of brown carbon. Presented at the American Meteorological Society 94th Annual Meeting, Atlanta, GA, February 2-6, 2014. R834799 (2014)
R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Williams BJ, Mitroo D, Martinez R, Zhang Y, Walker M, Oxford C, Zuo X, Hagan D, Dhawan S, Du L, Turner J, McMeeking G, King L, Guo H, Weber R, Baasandorj M, Hu L, Millet D. Highlights from the St. Louis Air Quality Regional Study (SLAQRS) 2013. Presented at the American Association for Aerosol Research (AAAR) 33rd Annual Conference, Orlando FL, October 20-24, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
R835402 (2014)
R835402 (Final)
  • Other: AAAR-Conference Program
    Exit
Presentation Xu L, Guo H, Cerully K, Bougiatioti, King L, Weber R, Nenes A, Ng NL, Carlton AM, Nguyen K. Chemical characterization of water soluble organic aerosol during SOAS using high resolution aerosol mass spectrometer. Presented at the American Geophysical Union (AGU) 46th Annual Fall Meeting, San Francisco, CA, December 9-13, 2013. R834799 (2014)
R834799 (2015)
R834799 (2016)
R834799C001 (2014)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Xu L, Middlebrook AM, Liao J, Welti A, Guo H, Lin JL, Bougiatioti A, Weber RJ, Nenes A, Holloway JS, Gilman J, Lerner BM, Graus M, Warneke C, Trainer M, de Gouw JA, Ng NL. Aircraft measurement of isoprene-derived organic aerosol during the Southeast Nexus (SENEX) campaign using an aerosol mass spectrometer. Poster presented at the American Geophysical Union (AGU) 47th Annual Fall Meeting, San Francisco, CA, December 15-19, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available
Presentation Xu L, Guo H, Boyd C, Klein M, Bougiatioti A, Cerully K, Hite J, Isaacman-VanWertz G, Kreisberg NM, Knote C, Olson K, Koss A, Goldstein AH, Hering SV, de Gouw J, Baumann K, Lee S-H, Nenes A, Weber R, Ng NL. Effects of anthropogenic emissions on aerosol formation from isoprene and monoterpenes in the southeastern United States. Presented at the 33rd Annual American Association for Aerosol Research (AAAR) Conference, Orlando, FL, October 20-24, 2014. R834799 (2015)
R834799 (2016)
R834799 (Final)
R834799C001 (2015)
R834799C001 (Final)
not available

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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