Grantee Research Project Results
Publications Details for Grant Number R826711
The Etiology and Pathogenesis of Airway Disease in Children from Rural Communities
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Centers for Children's Environmental Health and Disease Prevention Research (1998)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Journal Article | TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. | NATURE GENETICS | Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA | Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics 2000;25(2):187-191. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Subchronic endotoxin inhalation causes persistent airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA | Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. Subchronic endotoxin inhalation causes persistent airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(3):L755-L761. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. | JOURNAL OF IMMUNOLOGY | Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW | Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW. Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. Journal of Immunology 2002;169(7):3700-3709. |
R826711 (Final) R826711C003 (Final) |
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| Journal Article | Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. | EXPERIMENTAL LUNG RESEARCH | Chen W, Hunninghake GW | Chen W, Hunninghake GW. Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. Experimental Lung Research 2000;26(4):229-239. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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| Journal Article | Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. | EXPERIMENTAL LUNG RESEARCH | Chen W, Monick MM, Carter AB, Hunninghake GW | Chen W, Monick MM, Carter AB, Hunninghake GW. Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. Experimental Lung Research 2000;26(1):13-26. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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| Journal Article | Asthma prevalence and morbidity among rural Iowa schoolchildren. | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J | Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J. Asthma prevalence and morbidity among rural Iowa schoolchildren. Journal of Allergy and Clinical Immunology 2004;113(1):66-71. |
R826711 (Final) R826711C002 (Final) |
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| Journal Article | Endotoxin responsiveness and subchronic grain dust-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA | George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA. Endotoxin responsiveness and subchronic grain dust-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(2):L203-L213. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | George CL, White ML, O'Neill ME, Thorne PS, Schwartz DA, Snyder JM | George CL, White ML, O'Neill ME, Thorne PS, Schwartz DA, Snyder JM. Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(6):L1337-L1344. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | The role of toll-like receptor 4 in environmental airway injury in mice. | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Hollingsworth JW, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA | Hollingsworth II JW, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA. The role of toll-like receptor 4 in environmental airway injury in mice. American Journal of Respiratory and Critical Care Medicine 2004;170(2):126-132. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. | JOURNAL OF APPLIED PHYSIOLOGY | Kline JN, Jagielo PJ, Watt JL, Schwartz DA | Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. Journal of Applied Physiology 2000;89(3):1172-1178. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Variable airway responsiveness to inhaled lipopolysaccharide. | AMERICAN JOURNAL OF PHYSIOLOGY | Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA | Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine 1999;160(1):297-303. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Genes other than TLR4 are involved in the response to inhaled LPS. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA | Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. Genes other than TLR4 are involved in the response to inhaled LPS. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;281(5):L1106-L1114. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. | JOURNAL OF IMMUNOLOGY | Monick MM, Staber JM, Thomas KW, Hunninghake GW | Monick MM, Staber JM, Thomas KW, Hunninghake GW. Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. Journal of Immunology 2001;166(4):2681-2687. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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| Journal Article | Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. | JOURNAL OF BIOLOGICAL CHEMISTRY | Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW | Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW. Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. Journal of Biological Chemistry 2003;278(52):53035-53044. |
R826711 (Final) R826711C003 (Final) |
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| Journal Article | TNF-α and IL-1β are not essential to the inflammatory response in LPS-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA | Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA. TNF-α and IL-1β are not essential to the inflammatory response in LPS-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(1):L173-L180. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA | Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA. CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease. American Journal of Respiratory Cell and Molecular Biology 2002;27(4):474-480. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. | JOURNAL OF IMMUNOLOGY | Moreland JG, Bailey G, Nauseef WM, Weiss JP | Moreland JG, Bailey G, Nauseef WM, Weiss JP. Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. Journal of Immunology 2004;172(1):426-432. |
R826711 (Final) R826711C001 (Final) |
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| Journal Article | IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. | JOURNAL OF APPLIED PHYSIOLOGY | Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA | Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA. IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. Journal of Applied Physiology 2000;88(1):173-179. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Neutrophils play a critical role in development of LPS-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA | Savov JD, Gavett SH, Brass DM, Costa DL, Schwartz DA. Neutrophils play a critical role in development of LPS-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2002;283(5):L952-L962. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Fibrinolysis in LPS-induced chronic airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA | Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA. Fibrinolysis in LPS-induced chronic airway disease. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(4):L940-L948. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Ozone-induced acute pulmonary injury in inbred mouse strains. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA | Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, Foster WM, Schwartz DA. Ozone-induced acute pulmonary injury in inbred mouse strains. American Journal of Respiratory Cell and Molecular Biology 2004;31(1):69-77. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. | JOURNAL OF IMMUNOLOGY | Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM | Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. Journal of Immunology 1999;163(1):224-231. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Etiology and pathogenesis of airway disease in children and adults from rural communities. | ENVIRONMENTAL HEALTH PERSPECTIVES | Schwartz DA | Schwartz DA. Etiology and pathogenesis of airway disease in children and adults from rural communities. Environmental Health Perspectives 1999;107(Suppl 3):393-401. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Inhibition of LPS-induced airway hyperresponsiveness and airway inflammation by LPS antagonists. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Schwartz DA, Christ WJ, Kleeberger SR, Wohlford-Lenane CL | Schwartz DA, Christ WJ, Kleeberger SR, Wohlford-Lenane CL. Inhibition of LPS-induced airway hyperresponsiveness and airway inflammation by LPS antagonists. American Journal of Physiology-Lung Cellular and Molecular Physiology 2001;280(4):L771-L778. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Does inhalation of endotoxin cause asthma? | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | Schwartz DA | Schwartz DA. Does inhalation of endotoxin cause asthma? American Journal of Respiratory and Critical Care Medicine 2001;163(2):305-306. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. | JOURNAL OF BIOLOGICAL CHEMISTRY | Thomas KW, Monick MM, Staber JM, Yarovinsky TO, Carter AB, Hunninghake GW | Thomas KW, Monick MM, Staber JM, Yarovinsky T, Carter AB, Hunninghake GW. Respiratory syncytial virus inhibits apoptosis and induces NF-κB activity through a phosphatidylinositol 3-kinase-dependent pathway. Journal of Biological Chemistry 2002;277(1):492-501. |
R826711 (Final) R826711C003 (Final) |
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| Journal Article | β-Arrestin-2 regulates the development of allergic asthma. | THE JOURNAL OF CLINICAL INVESTIGATION | Walker JKL, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ | Walker JKL, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. β-Arrestin-2 regulates the development of allergic asthma. Journal of Clinical Investigation 2003;112(4):566-574. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Susceptibility to asbestos-induced and transforming growth factor-beta 1-induced fibroproliferative lung disease in two strains of mice. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR | Warshamana GS, Pociask DA, Sime P, Schwartz DA, Brody AR. Susceptibility to asbestos-induced and transforming growth factor-β1-induced fibroproliferative lung disease in two strains of mice. American Journal of Respiratory Cell and Molecular Biology 2002;27(6):705-713. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Allergen-induced airway disease is mouse strain dependent. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Whitehead GS, Walker JK , Berman KG, Foster WM, Schwartz DA | Whitehead GS, Walker JK , Berman KG, Foster WM, Schwartz DA. Allergen-induced airway disease is mouse strain dependent. American Journal of Physiology-Lung Cellular and Molecular Physiology 2003;285(1):L32-L42. |
R826711 (Final) R826711C004 (Final) |
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| Journal Article | Cytokine gene expression after inhalation of corn dust. | AMERICAN JOURNAL OF PHYSIOLOGY | Wohlford-Lenane CL, Deetz DC, Schwartz DA | Wohlford-Lenane CL, Deetz DC, Schwartz DA. Cytokine gene expression after inhalation of corn dust. American Journal of Physiology 1999;276(5 Pt 1):L736-L743. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA | Zeldin DC, Wohlford-Lenane C, Chulada P, Bradbury JA, Scarborough PE, Roggli V, Langenbach R, Schwartz DA. Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. American Journal of Respiratory Cell and Molecular Biology 2001;25(4):457-465. |
R826711 (Final) R826711C004 (Final) |
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| Presentation | Management of childhood asthma in the rural setting. | None | Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J | Chrischilles E, Ahrens R, Kuehl A, Kelly K, Thorne P, Burmeister L, Merchant J. Management of childhood asthma in the rural setting. Presented at the 60th American Academy of Allergy Asthma and Immunology Workshop on Asthma Care for the Medically Underserved, March 8, 2003. |
R826711 (Final) R826711C002 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.