Grantee Research Project Results
Publications Details for Grant Number R826135
Arsenic-Glutathione Interactions and Skin Cancer
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Journal Article | Arsenic and heavy metal contamination of vegetables grown in Samta village, Bangladesh. | None | Alam MGM, Snow ET, Tanaka A | Alam MG, Snow ET, Tanaka A. Arsenic and heavy metal contamination of vegetables grown in Samta village, Bangladesh. The Science of The Total Environment 2003;308(1-3):83-96. |
R826135 (Final) |
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Journal Article | In vitro effect of arsenical compounds on glutathione-related enzymes. | CHEMICAL RESEARCH IN TOXICOLOGY | Chouchane S, Snow ET | Chouchane S, Snow ET. In vitro effect of arsenical compounds on glutathione-related enzymes. Chemical Research in Toxicology 2001;14(5):517-522. |
R826135 (Final) |
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Journal Article | Effect of arsenic on transcription factor AP-1 and NF-kappa B DNA binding activity and related gene expression. | TOXICOLOGY LETTERS | Hu Y, Jin XM, Snow ET | Hu Y, Jin XM, Snow ET. Effect of arsenic on transcription factor AP-1 and NF-kappaB DNA binding activity and related gene expression. Toxicology Letters 2002;133(1):33-45. |
R826135 (Final) |
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Journal Article | Upregulation of glutathione-related genes and enzyme activities in cultured human cells by sublethal concentrations of inorganic arsenic. | TOXICOLOGICAL SCIENCES | Schuliga M, Chouchane S, Snow ET | Schuliga M, Chouchane S, Snow ET. Upregulation of glutathione-related genes and enzyme activities in cultured human cells by sublethal concentrations of inorganic arsenic. Toxicological Sciences 2002;70(2):183-192. |
R826135 (Final) |
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Journal Article | Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk? | None | Snow ET, Sykora P, Durham TR, Klein CB | Snow ET, Sykora P, Durham TR, Klein CB. Arsenic, mode of action at biologically plausible low doses: what are the implications for low dose cancer risk? Toxicology and Applied Pharmacology 2005; 207(2 Suppl 1):557-564. |
R826135 (Final) |
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Journal Article | Modulation of DNA polymerase beta-dependent base excision repair in cultured human cells after low dose exposure to arsenite. | None | Sykora P, Snow ET | Sykora P, Snow ET. Modulation of DNA polymerase beta-dependent base excision repair in cultured human cells after low dose exposure to arsenite. Toxicology and Applied Pharmacology 2008;228(3):385-394. |
R826135 (Final) |
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Presentation | Regulation of transcription factor DNA binding activity and related gene expression. | None | Hu Y, Snow ET | Hu Y, Snow ET. Regulation of transcription factor DNA binding activity and related gene expression. Presented at Metals 2001: International Conference on the Environmental Toxicology of Metals and Metalloids-Environmental Chemistry, Toxicology and Health Effects, South Molle Island Resort Conference Centre, Queensland, Australia, July 1-5, 2001. |
R826135 (Final) |
not available |
Presentation | The effect of arsenic on transcription factor DNA binding activity and related gene expression | None | Hu Y, Snow ET | Hu Y, Snow ET. The effect of arsenic on transcription factor DNA binding activity and related gene expression. Poster presented at the Second International Meeting of MEPSA (the Mutagenesis and Experimental Pathology Society of Australasia), December 6-10, 2000. |
R826135 (2000) |
not available |
Presentation | Arsenic-glutathione interactions and skin cancer. | None | Klein CB, Snow, ET | Klein CB, Snow, ET. Arsenic-glutathione interactions and skin cancer. Presented at the Environmental Protection Agency, National Center for Environmental Research, STAR Drinking Water Progress Review Meeting, Silver Spring, MD, February 22-23, 2001. |
R826135 (Final) |
not available |
Presentation | Arsenic Mechanisms and Biomarkers | None | Klein CB | Klein CB. Arsenic Mechanisms and Biomarkers. Presented at the 4th International Conference on Arsenic Exposure and Health Effects, San Diego, CA, June 18-22, 2000. |
R826135 (2000) |
not available |
Presentation | Molecular responses of human cells to low concentrations of arsenic | None | Klein CB | Klein CB. Molecular responses of human cells to low concentrations of arsenic. Presented at the Oxidative Responses in Health and Disease, A Joint meeting of ANZEMS, ASPET, and Free Radical Research Society, Sydney, Australia, December 1-4, 1999. |
R826135 (2000) |
not available |
Presentation | Sub-toxic arsenite induces a multi-component protective response against oxidative stress in human cells | None | Klein CB | Klein CB. Sub-toxic arsenite induces a multi-component protective response against oxidative stress in human cells. Presented at the 4th International Conference on Arsenic Exposure and Health Effects, San Diego, CA, June 18-22, 2000. |
R826135 (2000) |
not available |
Presentation | Transcriptional regulation of redox-related genes by micromolar arsenite in human fibroblasts | None | Klein CB | Klein CB. Transcriptional regulation of redox-related genes by micromolar arsenite in human fibroblasts. Presented at the Arsenic Technology Transfer Conference, Costa Mesa, CA, July 12-13, 2000. |
R826135 (2000) |
not available |
Presentation | Induction of multiple redox-related genes in fibroblasts and keratinocytes by low-dose arsenic. | None | Schuliga M, Hu Y, Snow ET | Schuliga M, Hu Y, Snow ET. Induction of multiple redox-related genes in fibroblasts and keratinocytes by low-dose arsenic. Presented at the MEPSA Meeting: Natural Products Which Modulate Tissue Repair, University of Sydney, Australia, November 29-30, 2001. |
R826135 (Final) |
not available |
Presentation | Induction of antioxidant activities by arsenite: implications for therapeutics and cancer | None | Schuliga M, Snow ET | Schuliga M, Snow ET. Induction of antioxidant activities by arsenite: implications for therapeutics and cancer. Presented at the Second International Meeting of MEPSA (the Mutagenesis and Experimental Pathology Society of Australasia), December 6-10, 2000. |
R826135 (2000) |
not available |
Presentation | The role of reactive oxygen species in arsenic induced modulation of antioxidant activities | None | Schuliga M, Donoghue N, Snow ET | Schuliga M, Donoghue N, Snow ET. The role of reactive oxygen species in arsenic induced modulation of antioxidant activities. Poster presented at the Second International Meeting of MEPSA (the Mutagenesis and Experimental Pathology Society of Australasia), December 6-10, 2000. |
R826135 (2000) |
not available |
Presentation | Arsenic induces a biphasic cellular response that is protective at low doses. | None | Snow ET, Schuliga M, Sykora P, Hu Y, Klein CB | Snow ET, Schuliga M, Sykora P, Hu Y, Klein CB. Arsenic induces a biphasic cellular response that is protective at low doses. Presented at Metals 2001: International Conference on the Environmental Toxicology of Metals and Metalloids-Environmental Chemistry, Toxicology and Health Effects, South Molle Island Resort Conference Centre, Queensland, Australia, July 1-5, 2001. |
R826135 (Final) |
not available |
Presentation | Chronic exposure to arsenic decreases transcriptional response to TPA and prevents skin cancer in mice. | None | Snow ET, Hu Y, Klein CB | Snow ET, Hu Y, Klein CB. Chronic exposure to arsenic decreases transcriptional response to TPA and prevents skin cancer in mice. Presented at the MEPSA Meeting: Natural Products Which Modulate Tissue Repair, University of Sydney, Australia, November 29-30, 2001. |
R826135 (Final) |
not available |
Presentation | Molecular responses of human skin cells to low dose arsenic | None | Snow ET, Schuliga M, Sykora P, Hu Y | Snow ET, Schuliga M, Sykora P, Hu Y. Molecular responses of human skin cells to low dose arsenic. Presented at the Second International Meeting of MEPSA (the Mutagenesis and Experimental Pathology Society of Australasia), December 6-10, 2000. |
R826135 (2000) |
not available |
Presentation | Coordinate up-regulation of base excision DNA repair by low dose arsenic. | None | Sykora, P. Snow, ET | Sykora, P. Snow, ET. Coordinate up-regulation of base excision DNA repair by low dose arsenic. Presented at the MEPSA Meeting: Natural Products Which Modulate Tissue Repair, University of Sydney, Australia, November 29-30, 2001. |
R826135 (Final) |
not available |
Presentation | Altered regulation of redox genes in liver cells by arsenic and methyl cysteinesulfoxide (MCSO). | None | Van Sinderen M, Hamilton K, Shuliga M, Sykora P, Snow ET | Van Sinderen M, Hamilton K, Shuliga M, Sykora P, Snow ET. Altered regulation of redox genes in liver cells by arsenic and methyl cysteinesulfoxide (MCSO). Poster presented at the MEPSA Meeting: Natural Products Which Modulate Tissue Repair, University of Sydney, Australia, November 29-30, 2001. |
R826135 (Final) |
not available |
Proceedings | Mode of action studies for assessing carcinogenic risks posed by inorganic arsenic | None | Andersen ME, Clewell HJ, III, Snow ET, Yager JW | Andersen ME, Clewell HJ, III, Snow ET, Yager JW. Mode of action studies for assessing carcinogenic risks posed by inorganic arsenic. In: Chappell WR, Abernathy CO, Calderon R, eds. Proceedings of the 3rd International Conference on Arsenic Exposure and Health Effects, Elsevier Science, Ltd, Publisher, 1999, pp. 397-406. |
R826135 (2000) |
not available |
Proceedings | Developing a quantitiative cancer simulation approach and research plan to support a biologically based risk assessment for arsenic carcinogenicity | None | Andersen M, Clewell H, Snow ET, Yager J | Andersen M, Clewell H, Snow ET, Yager J. Developing a quantitiative cancer simulation approach and research plan to support a biologically based risk assessment for arsenic carcinogenicity. In: Proceedings: Fourth International Conference on Managing Hazardous Air Pollutants, EPRI Publication No. TR-111024, pp. 2-61-2-73, 1999. |
R826135 (2000) |
not available |
Proceedings | Modulation of DNA repair and glutathione levels in human keratinocytes by micromolar arsenite | None | Snow ET, Hu Y, Yan CC, Chouchane, S | Snow ET, Hu Y, Yan CC, Chouchane S. Modulation of DNA repair and glutathione levels in human keratinocytes by micromolar arsenite. In: Chappell WR, Abernathy CO, Calderon R, eds. Proceedings of the 3rd International Conference on Arsenic Exposure and Health Effects, Elsevier Science, Ltd.,1999, pp. 243-251. |
R826135 (2000) R826135 (Final) |
not available |
Proceedings | Sub-toxic arsenite induces a multi-component protective response against oxidative stress in human cells. | None | Snow ET, Schuliga M, Chouchane S, Hu Y | Snow ET, Schuliga M, Chouchane S, Hu Y. Sub-toxic arsenite induces a multi-component protective response against oxidative stress in human cells. In:Chappell WR, Abernathy CO, Calderon RL, eds. Arsenic Exposure and Health Effects IV: Proceedings of the 4th International Conference on Arsenic Exposure and Health Effects, June 18-22, 2000, Elsevier Science, Ltd., San Diego, CA, 2001, pp. 265-275. |
R826135 (2000) R826135 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.