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Abstract (2)
Journal Article (20)
Presentation (2)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Abstract An IL-1 receptor antagonist can attenuate airway hyperresponsiveness developed following acute exposure to ozone. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Park J-W, Taube C, Kodama T, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Nick J, Kim SH, Dinarello CA, Gelfand EW Park J-W, Taube C, Kodama T, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Nick J, Kim SH, Dinarello CA, Gelfand EW. An IL-1 receptor antagonist can attenuate airway hyperresponsiveness developed following acute exposure to ozone. American Journal of Respiratory and Critical Care Medicine 2003;167(7):A639. R825702 (Final)
R825702C012 (Final)
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Abstract Complement, but not neutrophil, is critical for the development of airway hyperresponsiveness following acute ozone exposure. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Park J-W, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Holers VM, Gelfand EW Park J-W, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Holers VM, Gelfand EW. Complement, but not neutrophil, is critical for the development of airway hyperresponsiveness following acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 2003;167(7):A759. R825702 (Final)
R825702C012 (Final)
 not available
Journal Article Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on γδ T cells. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Cui Z-H, Joetham A, Aydintug MK, Hahn Y-S, Born WK, Gelfand EW Cui Z-H, Joetham A, Aydintug MK, Hahn Y-S, Born WK, Gelfand EW. Reversal of allergic airway hyperreactivity after long-term allergen challenge depends on γδ T cells. American Journal of Respiratory and Critical Care Medicine 2003;168(11):1324-1332. R825702 (Final)
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Journal Article Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-β 1 in airway epithelial cells by Mycoplasma pneumoniae. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Dakhama A, Kraft M, Martin RJ, Gelfand EW Dakhama A, Kraft M, Martin RJ, Gelfand EW. Induction of regulated upon activation, normal T cells expressed and secreted (RANTES) and transforming growth factor-β1 in airway epithelial cells by Mycoplasma pneumoniae. American Journal of Respiratory Cell and Molecular Biology 2003;29(3):344-351. R825702 (Final)
R825702C012 (Final)
Journal Article Calcitonin gene-related peptide: role in airway homeostasis. CURRENT OPINION IN PHARMACOLOGY Dakhama A, Larsen GL, Gelfand EW Dakhama A, Larsen GL, Gelfand EW. Calcitonin gene-related peptide: role in airway homeostasis. Current Opinion in Pharmacology 2004;4(3):215-220. R825702 (Final)
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Journal Article Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization. JOURNAL OF IMMUNOLOGY Gelfand EW, Joetham A, Cui Z-H, Balhorn A, Takeda K, Taube C, Dakhama A Gelfand EW, Joetham A, Cui Z-H, Balhorn A, Takeda K, Taube C, Dakhama A. Induction and maintenance of airway responsiveness to allergen challenge are determined at the age of initial sensitization. Journal of Immunology 2004;173(2):1298-1306. R825702 (Final)
R825702C012 (Final)
Journal Article CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, Gelfand EW Haczku A, Takeda K, Hamelmann E, Loader J, Joetham A, Redai I, Irvin CG, Lee JJ, Kikutani H, Conrad D, Gelfand EW. CD23 exhibits negative regulatory effects on allergic sensitization and airway hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine 2000;161(3):952-960. R825702 (Final)
R825702C012 (Final)
Journal Article Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW Hamelmann E, Takeda K, Haczku A, Cieslewicz G, Shultz L, Hamid Q, Xing Z, Gauldie J, Gelfand EW. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. American Journal of Respiratory Cell and Molecular Biology 2000;23(3):327-334. R825702 (Final)
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Journal Article Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Kanehiro A, Takeda K, Joetham A, Tomkinson A, Ikemura T, Irvin CG, Gelfand EW Kanehiro A, Takeda K, Joetham A, Tomkinson A, Ikemura T, Irvin CG, Gelfand EW. Timing of administration of anti-VLA-4 differentiates airway hyperresponsiveness in the central and peripheral airways in mice. American Journal of Respiratory and Critical Care Medicine 2000;162(3):1132-1139. R825702 (Final)
R825702C012 (Final)
Journal Article Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Kanehiro A, Ikemura T, Makela MJ, Lahn M, Joetham A, Dakhama A, Gelfand EW Kanehiro A, Ikemura T, Makela MJ, Lahn M, Joetham A, Dakhama A, Gelfand EW. Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. American Journal of Respiratory and Critical Care Medicine 2001;163(1):173-184. R825702 (Final)
R825702C012 (Final)
Journal Article Requirement for the p75 TNF-α receptor 2 in the regulation of airway hyperresponsiveness by γδ T cells. JOURNAL OF IMMUNOLOGY Kanehiro A, Lahn M, Makela MJ, Dakhama A, Joetham A, Rha Y-H, Born W, Gelfand EW Kanehiro A, Lahn M, Makela MJ, Dakhama A, Joetham A, Rha Y-H, Born W, Gelfand EW. Requirement for the p75 TNF-α receptor 2 in the regulation of airway hyperresponsiveness by γδ T cells. Journal of Immunology 2002;169(8):4190-4197. R825702 (Final)
R825702C012 (Final)
Journal Article Role of interleukin-12 in the regulation of CD4+ T cell apoptosis in a mouse model of asthma. None Kodama T, Kuribayashi K, Nakamura H, Fujita M, Fujita T, Takeda K, Dakhama A, Gelfand EW, Matsuyama T, Kitada O Kodama T, Kuribayashi K, Nakamura H, Fujita M, Fujita T, Takeda K, Dakhama A, Gelfand EW, Matsuyama T, Kitada O. Role of interleukin-12 in the regulation of CD4+ T cell apoptosis in a mouse model of asthma. Clinical and Experimental Immunology 2003;131(2):199-205. R825702 (Final)
R825702C012 (Final)
Journal Article Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY Larsen GL, White CW, Takeda K, Loader JE, Nguyen DDH, Joetham A, Groner Y, Gelfand EW Larsen GL, White CW, Takeda K, Loader JE, Nguyen DDH, Joetham A, Groner Y, Gelfand EW. Mice that overexpress Cu/Zn superoxide dismutase are resistant to allergen-induced changes in airway control. American Journal of Physiology-Lung Cellular and Molecular Physiology 2000;279(2):L350-L359. R825702 (Final)
R825702C012 (Final)
Journal Article The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Makela MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, Anderson L, Gelfand EW Makela MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, Anderson L, Gelfand EW. The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. American Journal of Respiratory and Critical Care Medicine 2002;165(6):824-831. R825702 (Final)
R825702C012 (Final)
Journal Article Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Makela MJ, Tripp R, Dakhama A, Park J-W, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW Makela MJ, Tripp R, Dakhama A, Park J-W, Ikemura T, Joetham A, Waris M, Anderson LJ, Gelfand EW. Prior airway exposure to allergen increases virus-induced airway hyperresponsiveness. The Journal of Allergy and Clinical Immunology 2003;112(5):861-869. R825702 (Final)
R825702C012 (Final)
Journal Article Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Park J-W, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Schultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW Park J-W, Taube C, Joetham A, Takeda K, Kodama T, Dakhama A, McConville G, Allen CB, Sfyroera G, Schultz LD, Lambris JD, Giclas PC, Holers VM, Gelfand EW. Complement activation is critical to airway hyperresponsiveness after acute ozone exposure. American Journal of Respiratory and Critical Care Medicine 2004;169(6):726-732. R825702 (Final)
R825702C012 (Final)
Journal Article Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW Park JW, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Donaldson DD, Gelfand EW. Respiratory syncytial virus-induced airway hyperresponsiveness is independent of IL-13 compared with that induced by allergen. The Journal of Allergy and Clinical Immunology 2003;112(6):1078-1087. R825702 (Final)
R825702C012 (Final)
Journal Article Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Park J-W, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim S-H, Dinarello CA, Gelfand EW Park J-W, Taube C, Swasey C, Kodama T, Joetham A, Balhorn A, Takeda K, Miyahara N, Allen CB, Dakhama A, Kim S-H, Dinarello CA, Gelfand EW. Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):830-836. R825702 (Final)
R825702C012 (Final)
Journal Article Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. JOURNAL OF IMMUNOLOGY Rha Y-H, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A, Gelfand EW Rha Y-H, Taube C, Haczku A, Joetham A, Takeda K, Duez C, Siegel M, Aydintug MK, Born WK, Dakhama A, Gelfand EW. Effect of microbial heat shock proteins on airway inflammation and hyperresponsiveness. Journal of Immunology 2002;169(9):5300-5307. R825702 (Final)
R825702C012 (Final)
Journal Article MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. JOURNAL OF BIOLOGICAL CHEMISTRY Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL. MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. Journal of Biological Chemistry 2001;276(7):5093-5100. R825702 (Final)
R825702C012 (Final)
Journal Article Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha Y-H, Park J-W, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW Taube C, Nick JA, Siegmund B, Duez C, Takeda K, Rha Y-H, Park J-W, Joetham A, Poch K, Dakhama A, Dinarello CA, Gelfand EW. Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology 2004;30(6):837-843. R825702 (Final)
R825702C012 (Final)
Journal Article A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. JOURNAL OF IMMUNOLOGY Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt M-C, Gundel R, Gelfand EW Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt M-C, Gundel R, Gelfand EW. A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. Journal of Immunology 2001;166(9):5792-5800. R825702 (Final)
R825702C012 (Final)
Presentation An IL-1 receptor antagonist can attenuate airway hyperresponsiveness developed following acute exposure to ozone. None Park J-W, Taube C, Kodama T, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Nick J, Kim SH, Dinarello CA, Gelfand EW Park J-W, Taube C, Kodama T, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Nick J, Kim SH, Dinarello CA, Gelfand EW. An IL-1 receptor antagonist can attenuate airway hyperresponsiveness developed following acute exposure to ozone. Presented at the 2003 American Thoracic Society International Conference, Seattle, WA, May 16-21, 2003. R825702 (Final)
R825702C012 (Final)
 not available
Presentation Complement, but not neutrophil, is critical for the development of airway hyperresponsiveness following acute ozone exposure. None Park J-W, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Holers VM, Gelfand EW Park J-W, Taube C, Yang ES, Joetham A, Balhorn A, Takeda K, Miyahara N, Dakhama A, Corrie A, Holers VM, Gelfand EW. Complement, but not neutrophil, is critical for the development of airway hyperresponsiveness following acute ozone exposure. Presented at the 2003 American Thoracic Society International Conference, Seattle, WA, May 16-21, 2003. R825702 (Final)
R825702C012 (Final)
 not available

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