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Grantee Research Project Results

Publications Details for Grant Number R839481

System toxicological approaches to define and predict the toxicity of Per and Polyfluoroalkyl Substances

RFA: National Priorities: Per- and Polyfluoroalkyl Substances (2018)

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Abstract (1)
Journal Article (12)
Presentation (25)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Abstract Practical Semiquantification Strategy for Estimating Suspect Per-and Polyfluoroalkyl Substance (PFAS) Concentrations JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J. Practical Semiquantification Strategy for Estimating Suspect Per-and Polyfluoroalkyl Substance (PFAS) Concentrations. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2023;34(5):939-947 R839481 (2021)
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Journal Article Background per- and polyfluoroalkyl substances (PFAS) in laboratory fish diet: Implications for zebrafish toxicological studies None Cao D, Rericha Y, Pawley C, Truong L, Tanguay R, Field J Cao D, Rericha Y, Pawley C, Truong L, Tanguay R, Field J. Background per-and polyfluoroalkyl substances (PFAS) in laboratory fish diet:Implications for zebrafish toxicological studies. SCIENCE OF THE TOTAL ENVIRONMENT 2022;842(156831). R839481 (2020)
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Journal Article The high persistence of PFAS is sufficient for their management as a chemical class ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS Cousins I, DeWett J, Gluge J, Goldenman G, Herzke D, Lohmann R, Ng C, Scheringer M, Wang Z Cousins I, DeWett J, Gluge J, Goldenman G, Herzke D, Lohmann R, Ng C, Scheringer M, Wang Z. The high persistence of PFAS is sufficient for their management as a chemical class. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS 2020;22(12):2307-2312. R839481 (2020)
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Journal Article Official health communications are failing PFAS-contaminated communities ENVIRONMENTAL HEALTH Ducatman A, LaPier J, Fuoco R, DeWett J Ducatman A, LaPier J, Fuoco R, DeWett J. Official health communications are failing PFAS-contaminated communities. ENVIRONMENTAL HEALTH 2022;21(1). R839481 (2020)
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Journal Article Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS? ENVIRONMENTAL SCIENCE & TECHNOLOGY Logmann R, Cousins I, DeWitt J, Gluge J, Goldenman G, Herzke D, Lindstrom A, Miller M, Ng C, Patton S, Scheringer M, Trier X, Wang Z Logmann R, Cousins I, DeWitt J, Gluge J, Goldenman G, Herzke D, Lindstrom A, Miller M, Ng C, Patton S, Scheringer M, Trier X, Wang Z. Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS?. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2020;54(20):12820-12828. R839481 (2020)
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Journal Article Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs) ENVIRONMENTAL SCIENCE & TECHNOLOGY McDonnough C, Li W, Bischel H, De Silva O, DeWitt J McDonnough C, Li W, Bischel H, De Silva O, DeWitt J. Widening the Lens on PFASs:Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs). ENVIRONMENTAL SCIENCE & TECHNOLOGY 2022;56(10):6004-6013. R839481 (2020)
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Journal Article Behavior Effects of Structurally Diverse Per- and Polyfluoroalkyl Substances in Zebrafish CHEMICAL RESEARCH IN TOXICOLOGY Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R. Behavior Effects of Structurally Diverse Per-and Polyfluoroalkyl Substances in Zebrafish. CHEMICAL RESEARCH IN TOXICOLOGY 2021;34(6):1409-1416. R839481 (2020)
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Journal Article Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations TOXICS Rericha Y, Truong L, Leong C, Cao D, Field J, Tanguay R Rericha Y, Truong L, Leong C, Cao D, Field J, Tanguay R. Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations. TOXICS 2022;10(7):372 R839481 (2020)
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Journal Article Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity ISCIENCE Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R. Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity. ISCIENCE 2022;25(2). R839481 (2020)
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Journal Article Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity TOXICOLOGICAL SCIENCES Rericha Y, Simonich M, Truong L, Tanguay R Rericha Y, Simonich M, Truong L, Tanguay R. Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity. TOXICOLOGICAL SCIENCES 2023;online ahead of print R839481 (2021)
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Journal Article Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish None Truong L, Reircha Y, Thunga P, Marvel S, Wallis D, Simonich M, Field J, Cao D, Reif D, Tanguay R Truong L, Reircha Y, Thunga P, Marvel S, Wallis D, Simonich M, Field J, Cao D, Reif D, Tanguay R. Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish. JOURNAL OF HAZARDOUS MATERIALS 2022;431. R839481 (2020)
R839481 (2022)
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Journal Article Distinct transcriptomic responses to structurally diverse per-and polyfluoroalkyl substances (PFAS) precede developmental toxicity in zebrafish. FRONTIERS IN TOXICOLOGY Rericha Y, St Mary L, Truong L, McClure RS, Martin JK, Leonard S, Thunga P, Simonich MT, Waters KM, Field JA, Tanguay RL Rericha Y, St Mary L, Truong L, McClure RS, Martin JK, Leonard S, Thunga P, Simonich MT, Waters KM, Field JA, Tanguay RL. Distinct transcriptomic responses to structurally diverse per-and polyfluoroalkyl substances (PFAS) precede developmental toxicity in zebrafish. Frontiers in Toxicology.;6:1425537. R839481 (2023)
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Journal Article Practical semiquantification strategy for estimating suspect per-and polyfluoroalkyl substance (PFAS) concentrations. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J. Practical semiquantification strategy for estimating suspect per-and polyfluoroalkyl substance (PFAS) concentrations. Journal of the American Society for Mass Spectrometry. 2023 Apr 5;34(5):939-47 R839481 (2023)
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Presentation Presented at the 12th World Congress on Alternatives to Animal Testing. None Using Zebrafish for Chemical Mixtures Risk Assessment Using Zebrafish for Chemical Mixtures Risk Assessment. Presented at the 12th World Congress on Alternatives to Animal Testing. Niagara Falls, Canada, August 29th, 2023. R839481 (2022)
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Presentation Presented at the Eurotox Meeting. None Full organism approaches to support the risk assessment of chemical mixtures, Workshop:In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023 Full organism approaches to support the risk assessment of chemical mixtures, Workshop:In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023. Presented at the Eurotox Meeting. Ljubljana Slovenia, September 12th, 2023. R839481 (2022)
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Presentation Presented at the HESI annual meeting-Not Just Another NAMs Meeting. None The Scientific Rationale for Using Complex Integrated Systems for Human Safety Assessments The Scientific Rationale for Using Complex Integrated Systems for Human Safety Assessments. Presented at the HESI annual meeting-Not Just Another NAMs Meeting. London, UK June 7th, 2023. R839481 (2022)
R839481 (2023)
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Presentation Presented at the Toxicology forum Winter Meeting. None Predicting Developmental and Neurotoxicity of Chemicals and Mixtures Using Multidimensional Zebrafish Data Predicting Developmental and Neurotoxicity of Chemicals and Mixtures Using Multidimensional Zebrafish Data. Presented at the Toxicology forum Winter Meeting. Pentagon City, January 24th, 2023. R839481 (2022)
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Presentation . None Invited Speaker for the 2023 National Institutes of Health EDI Director’s Speaker Series, Wednesday, November 6, 2023, Virtual Invited Speaker for the 2023 National Institutes of Health EDI Director’s Speaker Series, Wednesday, November 6, 2023, Virtual. R839481 (2023)
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Presentation . None Using Multidimensional Zebrafish Data to Protect and Improve Human Health, Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023 (Virtual) Using Multidimensional Zebrafish Data to Protect and Improve Human Health, Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023 (Virtual). R839481 (2023)
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Presentation Presented at Indo-US International Workshop on Emerging Issues in Environmental Public Health-Dissecting Genetic and Exposome Perspectives, National Environmental Engineering Research Institute Council of Scientific and Industrial Research, Nagpur India, January 4th, 2024. None Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish. Presented at Indo-US International Workshop on Emerging Issues in Environmental Public Health-Dissecting Genetic and Exposome Perspectives, National Environmental Engineering Research Institute Council of Scientific and Industrial Research, Nagpur India, January 4th, 2024. R839481 (2023)
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Presentation Presented at National Institute of Environmental Health Sciences (NIEHS), Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University & Centre for Chronic Disease Control (CCDC) Sonepat Haryana India, January 8, 2024. None Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish. Presented at National Institute of Environmental Health Sciences (NIEHS), Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University & Centre for Chronic Disease Control (CCDC) Sonepat Haryana India, January 8, 2024. R839481 (2023)
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Presentation Presented at Rutgers University, Piscataway, NJ, December 7th, 2023. None Using Multidimensional Zebrafish Data to Advance Environmental Health Sciences Using Multidimensional Zebrafish Data to Advance Environmental Health Sciences. Presented at Rutgers University, Piscataway, NJ, December 7th, 2023. R839481 (2023)
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Presentation Presented at Seoul National University of Science & Technology, Seoul Korea, April 11th 2024. None Thinking outside the tank to unravel chemical activity mechanisms Thinking outside the tank to unravel chemical activity mechanisms. Presented at Seoul National University of Science & Technology, Seoul Korea, April 11th 2024. R839481 (2023)
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Presentation Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 13, 2024. None Use of High Throughput Zebrafish Model for Screening of Potential Developmental Toxicants:Benefits Over Cellular Model and Remaining Challenges in Translation Use of High Throughput Zebrafish Model for Screening of Potential Developmental Toxicants:Benefits Over Cellular Model and Remaining Challenges in Translation. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 13, 2024. R839481 (2023)
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Presentation Presented at the 12tth World Congress on Alternatives to Animal Testing, Niagara Falls, Canada, August 29th 2023. None Using Zebrafish for Chemical Mixtures Risk Assessment Using Zebrafish for Chemical Mixtures Risk Assessment. Presented at the 12tth World Congress on Alternatives to Animal Testing, Niagara Falls, Canada, August 29th 2023. R839481 (2023)
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Presentation Presented at the 18th International Neurotoxicology Association Meeting, Durham, NC, May 22nd, 2023. None Expanding the zebrafish neurobehavioral screening toolbox to more rapidly detect neurobehavioral toxicants across life stage Expanding the zebrafish neurobehavioral screening toolbox to more rapidly detect neurobehavioral toxicants across life stage. Presented at the 18th International Neurotoxicology Association Meeting, Durham, NC, May 22nd, 2023. R839481 (2022)
R839481 (2023)
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Presentation Presented at the Academy for Lifelong Learning, Virtual, January 26, 2023. None Environmental Health Science in the 21st Century: New tools to Understand Environmental Determinants of Health Environmental Health Science in the 21st Century: New tools to Understand Environmental Determinants of Health. Presented at the Academy for Lifelong Learning, Virtual, January 26, 2023. R839481 (2022)
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Presentation Presented at the Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023. None Using Multidimensional Zebrafish Data to Protect and Improve Human Health Using Multidimensional Zebrafish Data to Protect and Improve Human Health. Presented at the Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023. R839481 (2022)
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Presentation Presented at the Food and Drug Administration Workshop State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs), College Park, Maryland, November 14-15, 2023. None Scientific Rationale and Opportunities to Use Integrated Models for DNT Assessments Scientific Rationale and Opportunities to Use Integrated Models for DNT Assessments. Presented at the Food and Drug Administration Workshop State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs), College Park, Maryland, November 14-15, 2023. R839481 (2023)
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Presentation Presented at the In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023 Eurotox Meeting, Ljubljana Slovenia, September 12th, 2023. None Full organism approaches to support the risk assessment of chemical mixtures Full organism approaches to support the risk assessment of chemical mixtures. Presented at the In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023 Eurotox Meeting, Ljubljana Slovenia, September 12th, 2023. R839481 (2023)
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Presentation Presented at the The University of Ottawa, Ottawa Canada February 9th, 2023. None Next-generation risk assessment:high-throughput toxicological assessments of zebrafish embryos to inform regulatory decision-making Next-generation risk assessment:high-throughput toxicological assessments of zebrafish embryos to inform regulatory decision-making. Presented at the The University of Ottawa, Ottawa Canada February 9th, 2023. R839481 (2022)
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Presentation Presented at the ToxMSDT Kick-Off Workshop, University of California Davis, September 28-30, 2023, . None Thinking Outside the Tank to Protect Human Health and the Environment, Keynote Presentation Thinking Outside the Tank to Protect Human Health and the Environment, Keynote Presentation. Presented at the ToxMSDT Kick-Off Workshop, University of California Davis, September 28-30, 2023, . R839481 (2023)
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Presentation Presented at the University of California Los Angeles, November 1, 2023. None Protecting Human Health through High Throughput Discovery of Gene and Environment Interactions in Zebrafish Protecting Human Health through High Throughput Discovery of Gene and Environment Interactions in Zebrafish. Presented at the University of California Los Angeles, November 1, 2023. R839481 (2023)
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Presentation Presented at the University of California San Francisco NIEHS Core Center Program Annual Meeting, Plenary Lecture, November 2, 2022. None Using Multidimensional Zebrafish Data to Protect and Improve Human Health Using Multidimensional Zebrafish Data to Protect and Improve Human Health. Presented at the University of California San Francisco NIEHS Core Center Program Annual Meeting, Plenary Lecture, November 2, 2022. R839481 (2022)
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Presentation Presented at the University of Florida, Gainesville FL, February 21st, 2024. None Thinking outside the tank to unravel chemical activity mechanisms Thinking outside the tank to unravel chemical activity mechanisms. Presented at the University of Florida, Gainesville FL, February 21st, 2024. R839481 (2023)
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Presentation Presented at the University of Illinois, Interdisciplinary Environmental Toxicology Program, November 16, 2023. None Using Multidimensional Zebrafish Data to Protect and Improve Human Health Using Multidimensional Zebrafish Data to Protect and Improve Human Health. Presented at the University of Illinois, Interdisciplinary Environmental Toxicology Program, November 16, 2023. R839481 (2023)
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Presentation Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. None Thinking outside the tank to unravel chemical activity mechanisms Thinking outside the tank to unravel chemical activity mechanisms. Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. R839481 (2022)
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Presentation Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. None Thinking outside the tank to unravel chemical activity mechanisms Thinking outside the tank to unravel chemical activity mechanisms. Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. R839481 (2022)
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