Grantee Research Project Results
Publications Details for Grant Number R839481
System toxicological approaches to define and predict the toxicity of Per and Polyfluoroalkyl Substances
RFA:
National Priorities: Per- and Polyfluoroalkyl Substances (2018)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | Practical Semiquantification Strategy for Estimating Suspect Per-and Polyfluoroalkyl Substance (PFAS) Concentrations | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J | Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J. Practical Semiquantification Strategy for Estimating Suspect Per-and Polyfluoroalkyl Substance (PFAS) Concentrations. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 2023;34(5):939-947 |
R839481 (2021) |
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| Journal Article | Background per- and polyfluoroalkyl substances (PFAS) in laboratory fish diet: Implications for zebrafish toxicological studies | None | Cao D, Rericha Y, Pawley C, Truong L, Tanguay R, Field J | Cao D, Rericha Y, Pawley C, Truong L, Tanguay R, Field J. Background per-and polyfluoroalkyl substances (PFAS) in laboratory fish diet:Implications for zebrafish toxicological studies. SCIENCE OF THE TOTAL ENVIRONMENT 2022;842(156831). |
R839481 (2020) |
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| Journal Article | The high persistence of PFAS is sufficient for their management as a chemical class | ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS | Cousins I, DeWett J, Gluge J, Goldenman G, Herzke D, Lohmann R, Ng C, Scheringer M, Wang Z | Cousins I, DeWett J, Gluge J, Goldenman G, Herzke D, Lohmann R, Ng C, Scheringer M, Wang Z. The high persistence of PFAS is sufficient for their management as a chemical class. ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS 2020;22(12):2307-2312. |
R839481 (2020) |
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| Journal Article | Official health communications are failing PFAS-contaminated communities | ENVIRONMENTAL HEALTH | Ducatman A, LaPier J, Fuoco R, DeWett J | Ducatman A, LaPier J, Fuoco R, DeWett J. Official health communications are failing PFAS-contaminated communities. ENVIRONMENTAL HEALTH 2022;21(1). |
R839481 (2020) |
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| Journal Article | Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS? | ENVIRONMENTAL SCIENCE & TECHNOLOGY | Logmann R, Cousins I, DeWitt J, Gluge J, Goldenman G, Herzke D, Lindstrom A, Miller M, Ng C, Patton S, Scheringer M, Trier X, Wang Z | Logmann R, Cousins I, DeWitt J, Gluge J, Goldenman G, Herzke D, Lindstrom A, Miller M, Ng C, Patton S, Scheringer M, Trier X, Wang Z. Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS?. ENVIRONMENTAL SCIENCE & TECHNOLOGY 2020;54(20):12820-12828. |
R839481 (2020) |
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| Journal Article | Widening the Lens on PFASs: Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs) | ENVIRONMENTAL SCIENCE & TECHNOLOGY | McDonnough C, Li W, Bischel H, De Silva O, DeWitt J | McDonnough C, Li W, Bischel H, De Silva O, DeWitt J. Widening the Lens on PFASs:Direct Human Exposure to Perfluoroalkyl Acid Precursors (pre-PFAAs). ENVIRONMENTAL SCIENCE & TECHNOLOGY 2022;56(10):6004-6013. |
R839481 (2020) |
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| Journal Article | Behavior Effects of Structurally Diverse Per- and Polyfluoroalkyl Substances in Zebrafish | CHEMICAL RESEARCH IN TOXICOLOGY | Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R | Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R. Behavior Effects of Structurally Diverse Per-and Polyfluoroalkyl Substances in Zebrafish. CHEMICAL RESEARCH IN TOXICOLOGY 2021;34(6):1409-1416. |
R839481 (2020) |
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| Journal Article | Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations | TOXICS | Rericha Y, Truong L, Leong C, Cao D, Field J, Tanguay R | Rericha Y, Truong L, Leong C, Cao D, Field J, Tanguay R. Dietary Perfluorohexanoic Acid (PFHxA) Exposures in Juvenile Zebrafish Produce Subtle Behavioral Effects across Generations. TOXICS 2022;10(7):372 |
R839481 (2020) |
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| Journal Article | Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity | ISCIENCE | Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R | Rericha Y, Cao D, Truong L, Simonich M, Field J, Tanguay R. Sulfonamide functional head on short-chain perfluorinated substance drives developmental toxicity. ISCIENCE 2022;25(2). |
R839481 (2020) |
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| Journal Article | Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity | TOXICOLOGICAL SCIENCES | Rericha Y, Simonich M, Truong L, Tanguay R | Rericha Y, Simonich M, Truong L, Tanguay R. Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity. TOXICOLOGICAL SCIENCES 2023;online ahead of print |
R839481 (2021) |
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| Journal Article | Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish | None | Truong L, Reircha Y, Thunga P, Marvel S, Wallis D, Simonich M, Field J, Cao D, Reif D, Tanguay R | Truong L, Reircha Y, Thunga P, Marvel S, Wallis D, Simonich M, Field J, Cao D, Reif D, Tanguay R. Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish. JOURNAL OF HAZARDOUS MATERIALS 2022;431. |
R839481 (2020) R839481 (2022) |
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| Journal Article | Distinct transcriptomic responses to structurally diverse per-and polyfluoroalkyl substances (PFAS) precede developmental toxicity in zebrafish. | FRONTIERS IN TOXICOLOGY | Rericha Y, St Mary L, Truong L, McClure RS, Martin JK, Leonard S, Thunga P, Simonich MT, Waters KM, Field JA, Tanguay RL | Rericha Y, St Mary L, Truong L, McClure RS, Martin JK, Leonard S, Thunga P, Simonich MT, Waters KM, Field JA, Tanguay RL. Distinct transcriptomic responses to structurally diverse per-and polyfluoroalkyl substances (PFAS) precede developmental toxicity in zebrafish. Frontiers in Toxicology.;6:1425537. |
R839481 (2023) |
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| Journal Article | Practical semiquantification strategy for estimating suspect per-and polyfluoroalkyl substance (PFAS) concentrations. | JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J | Cao D, Schwichtenberg T, Duan C, Xue L, Muensterman D, Field J. Practical semiquantification strategy for estimating suspect per-and polyfluoroalkyl substance (PFAS) concentrations. Journal of the American Society for Mass Spectrometry. 2023 Apr 5;34(5):939-47 |
R839481 (2023) |
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| Presentation | Presented at the 12th World Congress on Alternatives to Animal Testing. | None | Using Zebrafish for Chemical Mixtures Risk Assessment | Using Zebrafish for Chemical Mixtures Risk Assessment. Presented at the 12th World Congress on Alternatives to Animal Testing. Niagara Falls, Canada, August 29th, 2023. |
R839481 (2022) |
not available |
| Presentation | Presented at the Eurotox Meeting. | None | Full organism approaches to support the risk assessment of chemical mixtures, Workshop:In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023 | Full organism approaches to support the risk assessment of chemical mixtures, Workshop:In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023. Presented at the Eurotox Meeting. Ljubljana Slovenia, September 12th, 2023. |
R839481 (2022) |
not available |
| Presentation | Presented at the HESI annual meeting-Not Just Another NAMs Meeting. | None | The Scientific Rationale for Using Complex Integrated Systems for Human Safety Assessments | The Scientific Rationale for Using Complex Integrated Systems for Human Safety Assessments. Presented at the HESI annual meeting-Not Just Another NAMs Meeting. London, UK June 7th, 2023. |
R839481 (2022) R839481 (2023) |
not available |
| Presentation | Presented at the Toxicology forum Winter Meeting. | None | Predicting Developmental and Neurotoxicity of Chemicals and Mixtures Using Multidimensional Zebrafish Data | Predicting Developmental and Neurotoxicity of Chemicals and Mixtures Using Multidimensional Zebrafish Data. Presented at the Toxicology forum Winter Meeting. Pentagon City, January 24th, 2023. |
R839481 (2022) |
not available |
| Presentation | . | None | Invited Speaker for the 2023 National Institutes of Health EDI Director’s Speaker Series, Wednesday, November 6, 2023, Virtual | Invited Speaker for the 2023 National Institutes of Health EDI Director’s Speaker Series, Wednesday, November 6, 2023, Virtual. |
R839481 (2023) |
not available |
| Presentation | . | None | Using Multidimensional Zebrafish Data to Protect and Improve Human Health, Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023 (Virtual) | Using Multidimensional Zebrafish Data to Protect and Improve Human Health, Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023 (Virtual). |
R839481 (2023) |
not available |
| Presentation | Presented at Indo-US International Workshop on Emerging Issues in Environmental Public Health-Dissecting Genetic and Exposome Perspectives, National Environmental Engineering Research Institute Council of Scientific and Industrial Research, Nagpur India, January 4th, 2024. | None | Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish | Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish. Presented at Indo-US International Workshop on Emerging Issues in Environmental Public Health-Dissecting Genetic and Exposome Perspectives, National Environmental Engineering Research Institute Council of Scientific and Industrial Research, Nagpur India, January 4th, 2024. |
R839481 (2023) |
not available |
| Presentation | Presented at National Institute of Environmental Health Sciences (NIEHS), Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University & Centre for Chronic Disease Control (CCDC) Sonepat Haryana India, January 8, 2024. | None | Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish | Protecting Human Health Through High Throughput Discovery of Gene and Environment Interactions in Zebrafish. Presented at National Institute of Environmental Health Sciences (NIEHS), Centre for Health Analytics Research and Trends (CHART), Trivedi School of Biosciences, Ashoka University & Centre for Chronic Disease Control (CCDC) Sonepat Haryana India, January 8, 2024. |
R839481 (2023) |
not available |
| Presentation | Presented at Rutgers University, Piscataway, NJ, December 7th, 2023. | None | Using Multidimensional Zebrafish Data to Advance Environmental Health Sciences | Using Multidimensional Zebrafish Data to Advance Environmental Health Sciences. Presented at Rutgers University, Piscataway, NJ, December 7th, 2023. |
R839481 (2023) |
not available |
| Presentation | Presented at Seoul National University of Science & Technology, Seoul Korea, April 11th 2024. | None | Thinking outside the tank to unravel chemical activity mechanisms | Thinking outside the tank to unravel chemical activity mechanisms. Presented at Seoul National University of Science & Technology, Seoul Korea, April 11th 2024. |
R839481 (2023) |
not available |
| Presentation | Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 13, 2024. | None | Use of High Throughput Zebrafish Model for Screening of Potential Developmental Toxicants:Benefits Over Cellular Model and Remaining Challenges in Translation | Use of High Throughput Zebrafish Model for Screening of Potential Developmental Toxicants:Benefits Over Cellular Model and Remaining Challenges in Translation. Presented at Society of Toxicology Annual Meeting, Salt Lake City, UT, March 13, 2024. |
R839481 (2023) |
not available |
| Presentation | Presented at the 12tth World Congress on Alternatives to Animal Testing, Niagara Falls, Canada, August 29th 2023. | None | Using Zebrafish for Chemical Mixtures Risk Assessment | Using Zebrafish for Chemical Mixtures Risk Assessment. Presented at the 12tth World Congress on Alternatives to Animal Testing, Niagara Falls, Canada, August 29th 2023. |
R839481 (2023) |
not available |
| Presentation | Presented at the 18th International Neurotoxicology Association Meeting, Durham, NC, May 22nd, 2023. | None | Expanding the zebrafish neurobehavioral screening toolbox to more rapidly detect neurobehavioral toxicants across life stage | Expanding the zebrafish neurobehavioral screening toolbox to more rapidly detect neurobehavioral toxicants across life stage. Presented at the 18th International Neurotoxicology Association Meeting, Durham, NC, May 22nd, 2023. |
R839481 (2022) R839481 (2023) |
not available |
| Presentation | Presented at the Academy for Lifelong Learning, Virtual, January 26, 2023. | None | Environmental Health Science in the 21st Century: New tools to Understand Environmental Determinants of Health | Environmental Health Science in the 21st Century: New tools to Understand Environmental Determinants of Health. Presented at the Academy for Lifelong Learning, Virtual, January 26, 2023. |
R839481 (2022) |
not available |
| Presentation | Presented at the Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023. | None | Using Multidimensional Zebrafish Data to Protect and Improve Human Health | Using Multidimensional Zebrafish Data to Protect and Improve Human Health. Presented at the Baylor College of Medicine-RICE Superfund Seminar Series, May 16th, 2023. |
R839481 (2022) |
not available |
| Presentation | Presented at the Food and Drug Administration Workshop State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs), College Park, Maryland, November 14-15, 2023. | None | Scientific Rationale and Opportunities to Use Integrated Models for DNT Assessments | Scientific Rationale and Opportunities to Use Integrated Models for DNT Assessments. Presented at the Food and Drug Administration Workshop State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs), College Park, Maryland, November 14-15, 2023. |
R839481 (2023) |
not available |
| Presentation | Presented at the In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023 Eurotox Meeting, Ljubljana Slovenia, September 12th, 2023. | None | Full organism approaches to support the risk assessment of chemical mixtures | Full organism approaches to support the risk assessment of chemical mixtures. Presented at the In the Mix-Use of New Approach Methods for Chemical Mixtures Risk Assessment, 2023 Eurotox Meeting, Ljubljana Slovenia, September 12th, 2023. |
R839481 (2023) |
not available |
| Presentation | Presented at the The University of Ottawa, Ottawa Canada February 9th, 2023. | None | Next-generation risk assessment:high-throughput toxicological assessments of zebrafish embryos to inform regulatory decision-making | Next-generation risk assessment:high-throughput toxicological assessments of zebrafish embryos to inform regulatory decision-making. Presented at the The University of Ottawa, Ottawa Canada February 9th, 2023. |
R839481 (2022) |
not available |
| Presentation | Presented at the ToxMSDT Kick-Off Workshop, University of California Davis, September 28-30, 2023, . | None | Thinking Outside the Tank to Protect Human Health and the Environment, Keynote Presentation | Thinking Outside the Tank to Protect Human Health and the Environment, Keynote Presentation. Presented at the ToxMSDT Kick-Off Workshop, University of California Davis, September 28-30, 2023, . |
R839481 (2023) |
not available |
| Presentation | Presented at the University of California Los Angeles, November 1, 2023. | None | Protecting Human Health through High Throughput Discovery of Gene and Environment Interactions in Zebrafish | Protecting Human Health through High Throughput Discovery of Gene and Environment Interactions in Zebrafish. Presented at the University of California Los Angeles, November 1, 2023. |
R839481 (2023) |
not available |
| Presentation | Presented at the University of California San Francisco NIEHS Core Center Program Annual Meeting, Plenary Lecture, November 2, 2022. | None | Using Multidimensional Zebrafish Data to Protect and Improve Human Health | Using Multidimensional Zebrafish Data to Protect and Improve Human Health. Presented at the University of California San Francisco NIEHS Core Center Program Annual Meeting, Plenary Lecture, November 2, 2022. |
R839481 (2022) |
not available |
| Presentation | Presented at the University of Florida, Gainesville FL, February 21st, 2024. | None | Thinking outside the tank to unravel chemical activity mechanisms | Thinking outside the tank to unravel chemical activity mechanisms. Presented at the University of Florida, Gainesville FL, February 21st, 2024. |
R839481 (2023) |
not available |
| Presentation | Presented at the University of Illinois, Interdisciplinary Environmental Toxicology Program, November 16, 2023. | None | Using Multidimensional Zebrafish Data to Protect and Improve Human Health | Using Multidimensional Zebrafish Data to Protect and Improve Human Health. Presented at the University of Illinois, Interdisciplinary Environmental Toxicology Program, November 16, 2023. |
R839481 (2023) |
not available |
| Presentation | Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. | None | Thinking outside the tank to unravel chemical activity mechanisms | Thinking outside the tank to unravel chemical activity mechanisms. Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. |
R839481 (2022) |
not available |
| Presentation | Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. | None | Thinking outside the tank to unravel chemical activity mechanisms | Thinking outside the tank to unravel chemical activity mechanisms. Presented at the University of New Mexico School of Pharmacy, March 6th, 2023. |
R839481 (2022) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.