Grantee Research Project Results
Publications Details for Grant Number R826711C001
Mechanisms that Initiate, Promote, and Resolve Grain Dust/LPS Induced Inflammation
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Centers for Children's Environmental Health and Disease Prevention Research (1998)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Journal Article | TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. | NATURE GENETICS | Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA | Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nature Genetics 2000;25(2):187-191. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Endotoxin augments viral replication and the inflammatory response in respiratory syncytial virus-infected epithelium. | JOURNAL OF IMMUNOLOGY | Carter AB, Donohue MR, Knudtson KL, Gudmundsson G, Monick MM, Hunninghake GW | Carter AB, Donohue MR, Knudtson KL, Gudmundsson G, Monick MM, Hunninghake GW. Endotoxin augments viral replication and the inflammatory response in respiratory syncytial virus-infected epithelium. Journal of Immunology. |
R826711C001 (2000) |
not available |
| Journal Article | Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. | EXPERIMENTAL LUNG RESEARCH | Chen W, Hunninghake GW | Chen W, Hunninghake GW. Effects of ragweed and Th-2 cytokines on the secretion of IL-8 in human airway epithelial cells. Experimental Lung Research 2000;26(4):229-239. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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| Journal Article | Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. | EXPERIMENTAL LUNG RESEARCH | Chen W, Monick MM, Carter AB, Hunninghake GW | Chen W, Monick MM, Carter AB, Hunninghake GW. Activation of ERK2 by respiratory syncytial virus in A549 cells is linked to the production of interleukin 8. Experimental Lung Research 2000;26(1):13-26. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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| Journal Article | Endotoxin responsiveness and subchronic grain dust-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA | George CL, Jin H, Wohlford-Lenane CL, O'Neill ME, Phipps JC, O'Shaughnessy P, Kline JN, Thorne PS, Schwartz DA. Endotoxin responsiveness and subchronic grain dust-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(2):L203-L213. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. | JOURNAL OF APPLIED PHYSIOLOGY | Kline JN, Jagielo PJ, Watt JL, Schwartz DA | Kline JN, Jagielo PJ, Watt JL, Schwartz DA. Bronchial hyperreactivity is associated with enhanced grain dust-induced airflow obstruction. Journal of Applied Physiology 2000;89(3):1172-1178. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Variable airway responsiveness to inhaled lipopolysaccharide. | AMERICAN JOURNAL OF PHYSIOLOGY | Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA | Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA. Variable airway responsiveness to inhaled lipopolysaccharide. American Journal of Respiratory and Critical Care Medicine 1999;160(1):297-303. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. | JOURNAL OF IMMUNOLOGY | Monick MM, Staber JM, Thomas KW, Hunninghake GW | Monick MM, Staber JM, Thomas KW, Hunninghake GW. Respiratory syncytial virus infection results in activation of multiple protein kinase C isoforms leading to activation of mitogen-activated protein kinase. Journal of Immunology 2001;166(4):2681-2687. |
R826711 (Final) R826711C001 (2000) R826711C003 (Final) |
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| Journal Article | TNF-α and IL-1β are not essential to the inflammatory response in LPS-induced airway disease. | AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA | Moreland JG, Fuhrman RM, Wohlford-Lenane CL, Quinn TJ, Benda E, Pruessner JA, Schwartz DA. TNF-α and IL-1β are not essential to the inflammatory response in LPS-induced airway disease. American Journal of Physiology-Lung Cellular and Molecular Biology 2001;280(1):L173-L180. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. | JOURNAL OF IMMUNOLOGY | Moreland JG, Bailey G, Nauseef WM, Weiss JP | Moreland JG, Bailey G, Nauseef WM, Weiss JP. Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureus. Journal of Immunology 2004;172(1):426-432. |
R826711 (Final) R826711C001 (Final) |
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| Journal Article | IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. | JOURNAL OF APPLIED PHYSIOLOGY | Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA | Quinn TJ, Taylor S, Wohlford-Lenane CL, Schwartz DA. IL-10 reduces grain dust-induced airway inflammation and airway hyperreactivity. Journal of Applied Physiology 2000;88(1):173-179. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) R826711C004 (Final) |
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| Journal Article | Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. | JOURNAL OF IMMUNOLOGY | Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM | Schwartz DA, Wohlford-Lenane CL, Quinn TJ, Krieg AM. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. Journal of Immunology 1999;163(1):224-231. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Etiology and pathogenesis of airway disease in children and adults from rural communities. | ENVIRONMENTAL HEALTH PERSPECTIVES | Schwartz DA | Schwartz DA. Etiology and pathogenesis of airway disease in children and adults from rural communities. Environmental Health Perspectives 1999;107(Suppl 3):393-401. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
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| Journal Article | Cytokine gene expression after inhalation of corn dust. | AMERICAN JOURNAL OF PHYSIOLOGY | Wohlford-Lenane CL, Deetz DC, Schwartz DA | Wohlford-Lenane CL, Deetz DC, Schwartz DA. Cytokine gene expression after inhalation of corn dust. American Journal of Physiology 1999;276(5 Pt 1):L736-L743. |
R826711 (Final) R826711C001 (2000) R826711C002 (2000) |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.