Grantee Research Project Results
Publications Details for Grant Number R826248
Mechanism of Manganese-Induced Neurotoxicity
Other Views
- All
Publications - Selected
Publication Types - Journal
Articles - Publications Submitted
After Final Report - Redisplay this page without
Reference Title, Journal, and Author Columns - Display this Page
in RIS Format
| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Abstract | The iron transporter DMT1 (or Nramp2 or DCT1) is located mostly in endosomes in normal and Belgrade rat reticulocytes. | BLOOD | Garrick MD, Fletcher RJ, Dolan KG, Romano MA, Walowitz J, Roth JA, Umbreit JN, Conrad ME, Garrick LM | Garrick MD, Fletcher RJ, Dolan KG, Romano MA, Walowitz J, Roth JA, Umbreit JN, Conrad ME, Garrick LM. The iron transporter DMT1 (or Nramp2 or DCT1) is located mostly in endosomes in normal and Belgrade rat reticulocytes. Blood 1999;94(Suppl 1):403a, Abstract 1786. |
R826248 (Final) |
not available |
| Abstract | Factors associated with nuclear localization of the -IRE isoform of DMT1 (Nramp2/DCT1). | BLOOD | Garrick MD, Horbinski C, Dolan KG, Feng L, Burdo J, Connor J, Higgins D, Roth JA | Garrick MD, Horbinski C, Dolan KG, Feng L, Burdo J, Connor J, Higgins D, Roth JA. Factors associated with nuclear localization of the -IRE isoform of DMT1 (Nramp2/DCT1). Blood 2001;96(Suppl 1):227a, Abstract 971. |
R826248 (Final) |
not available |
| Abstract | Polyethyleneimine (PEI)-mediated transfection of sympathetic neurons in vitro. | JOURNAL OF NEUROSCIENCE RESEARCH | Garrick MD, Dolan KG, Roth JA | Garrick MD, Dolan KG, Roth JA. Polyethyleneimine (PEI)-mediated transfection of sympathetic neurons in vitro. Journal of Neuroscience Research 1999;2003, Abstract No. 795.13. |
R826248 (2000) R826248 (Final) |
not available |
| Abstract | Tissue-specific differential localization of isoforms of the iron transporter DMT1 (Nramp2/DCT1) | None | Garrick MD, Horbinski C, Higgins D, Dolan KG, Feng L, Roth JA | Garrick MD, Horbinski C, Higgins D, Dolan KG, Feng L, Roth JA. Tissue-specific differential localization of isoforms of the iron transporter DMT1 (Nramp2/DCT1). International Journal of Hematology 2000;72(Suppl 1):2, Abstract No. 15728. |
R826248 (2000) R826248 (Final) |
not available |
| Abstract | Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells | None | Walowitz J, Roth JA | Walowitz J, Roth JA. Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells. FASEB Journal 1999;13, Abstract No. 213.4. |
R826248 (1999) R826248 (2000) R826248 (Final) |
not available |
| Journal Article | DMT1: a mammalian transporter for multiple metals. | BIOMETALS | Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM | Garrick MD, Dolan KG, Horbinski C, Ghio AJ, Higgins D, Porubcin M, Moore EG, Hainsworth LN, Umbreit JN, Conrad ME, Feng L, Lis A, Roth JA, Singleton S, Garrick LM. DMT1: a mammalian transporter for multiple metals. BioMetals 2003;16(1):41-54. |
R826248 (Final) |
|
| Journal Article | Increased MAP1B expression without increased phosphorylation in manganese-treated PC12Mn cells. | EXPERIMENTAL CELL RESEARCH | Larsen KE, Pacheco M, Roth J, Aletta JM | Larsen KE, Pacheco M, Roth J, Aletta JM. Increased MAP1B expression without increased phosphorylation in manganese-treated PC12Mn cells. Experimental Cell Research 1998;245(1):105-115. |
R826248 (1999) R826248 (2000) R826248 (Final) |
|
| Journal Article | Manganese induces neurite outgrowth in PC12 cells via upregulation of αv integrins. | BRAIN RESEARCH | Lein P, Gallagher PJ, Amodeo J, Howie H, Roth JA | Lein P, Gallagher PJ, Amodeo J, Howie H, Roth JA. Manganese induces neurite outgrowth in PC12 cells via upregulation of αv integrins. Brain Research 2000;885(2):220-230. |
R826248 (2000) R826248 (Final) |
|
| Journal Article | Melatonin promotes osteoblast differentiation and bone formation. | JOURNAL OF BIOLOGICAL CHEMISTRY | Roth JA, Kim BG, Lin WL, Cho MI | Roth JA, Kim BG, Lin WL, Cho MI. Melatonin promotes osteoblast differentiation and bone formation. Journal of Biological Chemistry 1999;274(31):22041-22047. |
R826248 (Final) |
|
| Journal Article | Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation. | JOURNAL OF NEUROSCIENCE RESEARCH | Roth JA, Feng L, Walowitz J, Browne RW | Roth JA, Feng L, Walowitz J, Browne RW. Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation. Journal of Neuroscience Research 2000;61(2):162-171. |
R826248 (2000) R826248 (Final) |
|
| Journal Article | Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. | JOURNAL OF NEUROSCIENCE | Roth JA, Horbinski C, Feng L, Dolan KG, Higgins D, Garrick MD | Roth JA, Horbinski C, Feng L, Dolan KG, Higgins D, Garrick MD. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. Journal of Neuroscience 2000;20(20):7595-7601. |
R826248 (2000) R826248 (Final) |
|
| Journal Article | Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors. | BRAIN RESEARCH | Roth JA, Rosenblatt T, Lis A, Bucelli R | Roth JA, Rosenblatt T, Lis A, Bucelli R. Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors. Brain Research 2001;919(1):139-146. |
R826248 (Final) |
|
| Journal Article | Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells. | JOURNAL OF NEUROSCIENCE RESEARCH | Roth JA, Feng L, Dolan KG, Lis A, Garrick MD | Roth JA, Feng L, Dolan KG, Lis A, Garrick MD. Effect of the iron chelator desferrioxamine on manganese-induced toxicity of rat pheochromocytoma (PC12) cells. Journal of Neuroscience Research 2002;68(1):76-83. |
R826248 (Final) |
|
| Journal Article | Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. | NEUROTOXICOLOGY | Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD | Roth JA, Horbinski C, Higgins D, Lein P, Garrick MD. Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. NeuroToxicology 2002;23(2):147-157. |
R826248 (Final) |
|
| Journal Article | Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells. | JOURNAL OF NEUROSCIENCE RESEARCH | Walowitz JL, Roth JA | Walowitz JL, Roth JA. Activation of ERK1 and ERK2 is required for manganese-induced neurite outgrowth in rat pheochromocytoma (PC12) cells. Journal of Neuroscience Research 1999;57(6):847-854. |
R826248 (1999) R826248 (2000) R826248 (Final) |
|
| Presentation | Mechanism of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. | None | Roth JA | Roth JA. Mechanism of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Presented at the 9th International Ferroalloys Congress and the Manganese 2001 Health Issues Symposium, Quebec City, Canada, June 3-6, 2001. |
R826248 (Final) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.