Grantee Research Project Results
Publications Details for Grant Number R835738C001
Airway Epithelium Organotypic Culture as a Platform forAdverseOutcomesPathway Assessment of Engineered Nanomaterials
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Organotypic Culture Models for Predictive Toxicology Center (2013)
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Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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Abstract | Primary mouse airway epithelial cells are resistant to silver nanoparticles. | THE TOXICOLGIST | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. The Toxicologist 2016;150(S-1):10. |
R835738 (2016) R835738 (2017) R835738C001 (2016) |
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Abstract | Primary mouse airway epithelial cells are resistant to silver nanoparticles. | None | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. The Toxicologist 2016;150(Suppl 1):10. |
R835738C001 (2015) R835738C003 (2017) |
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Book Chapter | Excretory processes in toxicology: drug transporters in drug development. | None | Van Ness K, Kelly E | Van Ness K, Kelly E. Excretory processes in toxicology:drug transporters in drug development. In:McQueen CA, ed. Comprehensive Toxicology, Third Edition. Volume 1:General Principles, Oxford, UK:Elsevier Ltd., 2018, Chapter 8, pp. 143-164. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) |
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Journal Article | Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. | DRUG METABOLISM AND DISPOSITION | Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G | Bajaj, P., Chowdhury SK, Yucha R, Kelly EJ and Xiao G. Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metabolism and Disposition 2018: 46(11);1692-1702. |
R835738C001 (2018) R835738C002 (2018) |
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Journal Article | The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis. | REDOX BIOLOGY | Cartwright MM, Schmuck SC, Corredor C, Wang B, Scoville DK, Chisholm CR, Wilkerson HW, Afsharinejad Z, Bammler TK, Posner JD, Shutthanandan V, Baer DR, Mitra S, Altemeier WA, Kavanagh TJ | Cartwright MM, Schmuck SC, Corredor C, Wang B, Scoville DK, Chisholm CR, Wilkerson HW, Afsharinejad Z, Bammler TK, Posner JD, Shutthanandan V, Baer DR, Mitra S, Altemeier WA, Kavanagh TJ. The pulmonary inflammatory response to multiwalled carbon nanotubes is influenced by gender and glutathione synthesis. Redox Biology 2016;9:264-275. |
R835738 (2016) R835738 (2017) R835738C001 (2016) |
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Journal Article | Short-term inhalation study of graphene oxide nanoplates. | None | Kim YH, Jo MS, Kim JK, Shin JH, Baek JE, Park HS, An HJ, Lee JS, Kim BW, KH Kim, Ahn KH, Jeon KS, Oh SM, Lee JH, Workman T, Faustman EM, Yu IJ | Kim YH, Jo MS, Kim JK, Shin JH, Baek JE, Park HS, An HJ, Lee JS, Kim BW, Kim HP, Ahn KH, Jeon KS, Oh SM, Lee JH, Workman T, Faustman EM, Yu IJ. Short-term inhalation study of graphene oxide nanoplates. Nanotoxicology 2018;12(3):224-238. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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Journal Article | Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. | CHEMICAL RESEARCH IN TOXICOLOGY | Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP,Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, KostalJ Kavanagh TJ (2018) | Melnikov F, Botta D, White CC, Schmuck SC, Schaupp CM, Gallagher EP, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, Kostal J and Kavanagh TJ. Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis. Chemical Research in Toxicology2019:32(3);421-436 |
R835738C001 (2018) R835738C003 (2018) R835738C004 (2018) |
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Journal Article | A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS | Monteiro, M. B., Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS. A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. Journal of the American Society of Nephrology 2018:29(12);2820-2833. |
R835738C001 (2018) R835738C002 (2018) |
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Journal Article | The Effects of Gene × Environment Interactions on Silver Nanoparticle Toxicity in the Respiratory System | None | Nicholas TP, Kavanaugh T, Faustman EM, Altermeier WA | Nicholas TP, Kavanaugh T, Faustman EM, Altermeier WA. The Effects of Gene × Environment Interactions on Silver Nanoparticle Toxicity in the Respiratory System. Chemical Research in Toxicology 2019:32(6); 952-968. |
R835642 (Final) R835738C001 (2018) |
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Journal Article | Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. | None | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight 2017;2(21):e94929 (18 pp.). |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) |
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Journal Article | Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. | None | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS | Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS. Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen. JCI Insight 2017;2(21):94929 (18 pp.). |
R835738C001 (2017) |
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Journal Article | Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. | None | Park JJ, Weldon BA, Hong S, Workman T, Griffith WC, Park JH, Faustman EM | Park JJ, Weldon BA, Hong S, Workman T, Griffith WC, Park JH, Faustman EM. Characterization of 3D embryonic C57BL/6 and A/J mouse midbrain micromass in vitro culture systems for developmental neurotoxicity testing. Toxicology In Vitro 2018;48:33-44. |
R835738 (2017) R835738C001 (2018) R835738C004 (2018) R835738C005 (2018) |
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Journal Article | Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. | SCIENTIFIC REPORTS | Sakolish C, Weber EJ, Kelly EJ, Hummelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Chiu WA, Rusyn I | Sakolish, C., Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I. Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. Scientific Reports 2018: 8(1);14882 |
R835738C001 (2018) R835738C002 (2018) |
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Journal Article | Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice. | None | Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ | Scoville DK, Botta D, Galdanes K, Schmuck SC, White CC, Stapleton PL, Bammler TK, MacDonald JW, Altemeier WA, Hernandez M, Kleeberger SR, Chen LC, Gordon T, Kavanagh TJ. Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice. FASEB Journal 2017;31(10):4600-4611. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C002 (2017) |
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Journal Article | Quantum dot induced acute changes in lung mechanics are mouse strain dependent | INHALATION TOXICOLOGY | Scoville DK, White CC, Botta D, Afsharinejad Z, Bammler TK, Gao X, Altemeier WA, Kavanaugh T | Scoville DK, White CC, Botta D, An D, Afsharinejad Z, Bammler TK, Gao X, Altemeier WA, Kavanagh TJ. Quantum dot induced acute changes in lung mechanics are mouse strain dependent. Inhalation Toxicology 2018; 30(9-10):397-403. |
R835738C001 (2018) |
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Journal Article | Quantum dots and mouse strain influence house dust mite-induced allergic airway disease. | None | Scoville DK, Nolin JD, Ogden HL, An D, Afsharinejad Z, Johnson BW,Bammler TK, Gao X, Frevert CW, Altemeier WA, Hallstrand TS, Kavanagh TJ | Scoville DK, Nolin JD, Ogden HL, An D, Afsharinejad Z, Johnson BW, Bammler TK, Gao X, Frevert CW, Altemeier WA, Hallstrand TS, Kavanagh TJ. Quantum dots and mouse strain influence house dust mite-induced allergic airway disease. TOXICOLOGY AND APPLIED PHARMACOLOGY 2019:368;55-62 |
R835738C001 (2018) |
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Journal Article | Microphysiological systems to assess nonclinical toxicity. | None | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ | Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ. Microphysiological systems to assess nonclinical toxicity. Current Protocols in Toxicology 2017;73(1):14.18.1-14.18.28. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2018) R835738C005 (2017) |
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Journal Article | In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. | None | Weldon BA, Griffith WC, Workman T, Scoville DK, Kavanagh TJ, Faustman EM | Weldon BA, Griffith WC, Workman T, Scoville DK, Kavanagh TJ, Faustman EM. 2018. In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 2018;10(4):e1507. |
R835738 (2017) R835738C001 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) R835738C005 (2018) |
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Presentation | Primary mouse airway epithelial cells are resistant to silver nanoparticles. | None | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ | Altemeier WA, Haick A, Mittelsteadt KL, Kavanagh TJ. Primary mouse airway epithelial cells are resistant to silver nanoparticles. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. |
R835738 (2016) R835738 (2017) R835738C001 (2016) |
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Presentation | Development of human organotypic culture systems to model airway biology. | None | Altemeier WA, Nolin JD, Lai Y, Mulligan MS, Hallstrand TS | Altemeier WA, Nolin JD, Lai Y, Mulligan MS, Hallstrand TS. Development of human organotypic culture systems to model airway biology. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) |
not available |
Presentation | Development of human organotypic culture systems to model airway biology. | None | Altemeier WA, Nolin JD, Lai Y, Mulligan MS, Hallstrand TS | Altemeier WA, Nolin JD, Lai Y, Mulligan MS, Hallstrand TS. Development of human organotypic culture systems to model airway biology. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738C001 (2017) |
not available |
Presentation | Systems biology methods for translation of scientific findings across model platforms: identifying normal development versus chemical signals in complex systems. | None | Faustman EM | Faustman EM. Systems biology methods for translation of scientific findings across model platforms: identifying normal development versus chemical signals in complex systems. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
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Presentation | Using systems based approaches for refinement, integration and translation. | None | Faustman E, French E, Eaton D, Kelly E, Kavanagh T | Faustman E, French E, Eaton D, Kelly E, Kavanagh T. Using systems based approaches for refinement, integration and translation. Minicourse presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2018) R835738C003 (2018) |
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Presentation | Emergent technologies for evaluating drug and xenobiotic disposition. | None | Kelly EJ | Kelly EJ. Emergent technologies for evaluating drug and xenobiotic disposition. Presented at the 21st North American ISSX Meeting of the International Society for the Study of Xenobiotics (ISSX), Providence, RI, September 24-28, 2017 (symposium co-chair). |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C005 (2017) |
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Presentation | Microphysiological system models and the Lautenberg Chemical Safety for the 21st Century Act. | None | Klieforth B, Shaffer RM, mith M, Faustman EM | Klieforth B, Shaffer RM, Smith M, Faustman EM. Microphysiological system models and the Lautenberg Chemical Safety for the 21st Century Act. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C002 (2018) R835738C004 (2017) R835738C004 (2018) R835738C005 (2017) |
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Presentation | Optimization of airway epithelium organotypic culture models as a platform for adverse outcome pathway assessment of engineered nanomaterials. | None | Nicholas T, Haick A, Faustman E, Altemeier WA | Nicholas T, Haick A, Faustman E, Altemeier WA. Optimization of airway epithelium organotypic culture models as a platform for adverse outcome pathway assessment of engineered nanomaterials. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C002 (2017) |
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Presentation | Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. | None | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA. Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. Presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738C001 (2017) R835738C004 (2017) |
not available |
Presentation | Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. | None | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA | Nicholas T, Haick A, Kavanagh TJ, Faustman E, Altemeier WA. Optimization of three-dimensional airway epithelium co-culture system as a platform for adverse outcome pathway assessment of engineered nanomaterials. Poster presented at the Society of Toxicology 56th Annual Meeting and ToxExpo, Baltimore, MD, March 12-16, 2017. |
R835738 (2016) R835738 (2017) R835738C001 (2016) R835738C002 (2017) |
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Presentation | Differentiation state of airway epithelium organotypic culture models is a potential mediator of silver nanoparticle-induced toxicity. | None | Nicholas T, Haick A, Kavangh TJ, Faustman E, Altemeier WA | Nicholas T, Haick A, Kavangh TJ, Faustman E, Altemeier WA. Differentiation state of airway epithelium organotypic culture models is a potential mediator of silver nanoparticle-induced toxicity. Presented at the Society of Toxicology 57th Annual Meeting and ToxExpo, San Antonio, TX, March 11-15, 2018. |
R835738 (2017) R835738C001 (2018) |
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Presentation | P. | None | Nicholas, T | Nicholas, T.P., Haick, A.K., Workman, T., Griffith, W.C., Kavanagh, T.J., Faustman, E.M., Altemeier, W.A. The Effects of Genetic Strain and Differentiation Condition on Silver Nanoparticle-Induced Toxicity in Airway Epithelium Organotypic Culture Models. (Presented at STAR Organotypic Culture Models for Predictive Toxicology Research Centers Progress Review). |
R835738C001 (2018) |
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Presentation | Practical promotion of the 3Rs in animal models of lung disease. | None | Pekow C, Altemeier WA | Pekow C, Altemeier WA. Practical promotion of the 3Rs in animal models of lung disease. Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences (WC10), Seattle, WA, August 20-24, 2017. |
R835738 (2017) R835738C001 (2017) R835738C001 (2018) R835738C005 (2017) |
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Presentation | Nicholas, T. | None | 3 | 3. Nicholas, T.P., Haick, A.K., Workman, T., Griffith, W.C., Kavanagh, T.J., Faustman, E.M., Altemeier, W.A. Effects of Genetic Strain and Differentiation Condition on Silver Nanoparticle Toxicity in Airway Epithelium Organotypic Culture Models. (2019 Society of Toxicology meeting). |
R835738C001 (2018) |
not available |
Presentation | P. | None | Nicholas, T | Nicholas, T.P., Haick, A.K., Workman, T., Griffith, W.C., Kavanagh, T.J., Faustman, E.M., Altemeier, W.A. Effects of Genetic Strain and Differentiation Condition on Silver Nanoparticle Toxicity in Airway Epithelium Organotypic Culture Models. (2019 Society of Toxicology meeting). |
R835738C001 (2018) |
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Symposium | . | None | Ed Kelly, Symposium Co-Chair, 2017 North American Annual ISSX Annual Meeting, Providence, RI, Emergent Technologies for Evaluating Drug Xenobiotic Disposition | Kelly E. Symposium Co-Chair of the 21st North American ISSX Meeting, Emergent Technologies for Evaluating Drug and Xenobiotic Disposition, Providence, RI, September 24-28, 2017. |
R835738 (2017) R835738C001 (2018) R835738C002 (2017) R835738C005 (2017) R835738C005 (2018) |
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.