Grantee Research Project Results
Publications Details for Grant Number R828610
Chlorotriazine Protein Binding: Biomarkers of Exposure & Susceptibility
RFA:
Biomarkers for the Assessment of Exposure and Toxicity in Children (2000)
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
|---|---|---|---|---|---|---|
| Dissertation/Thesis | Quantitative analysis of atrazine and its chlorinated metabolites in plasma following a single oral gavage dose. | None | Brzezicki J | Brzezicki J. Quantitative analysis of atrazine and its chlorinated metabolites in plasma following a single oral gavage dose. M.S. Thesis. Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, CO, Fall 2002. |
R828610 (Final) |
not available |
| Dissertation/Thesis | Proteomic based assessment of agricultural chemicals utilizing biological markers. | None | Greg Dooley | Greg Dooley. Proteomic based assessment of agricultural chemicals utilizing biological markers. Ph.D. Dissertation. Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, CO, Fall 2007 (expected). |
R828610 (Final) |
not available |
| Dissertation/Thesis | Unraveling the divergent biological effect of 3,3’,4,4’,5-pentachloro biphenyl (PCB126) toward understanding the role of gene expression. | None | Maier MSV | Maier MSV. Unraveling the divergent biological effect of 3,3’,4,4’,5-pentachloro biphenyl (PCB126) toward understanding the role of gene expression. Ph.D. Dissertation. Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, CO, Spring 2005. |
R828610 (Final) |
not available |
| Dissertation/Thesis | Integrating tissue dosimetry and mode of action to evaluate atrazine dose-response. | None | McMullin T | McMullin T. Integrating tissue dosimetry and mode of action to evaluate atrazine dose-response. Ph.D. Dissertation. Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, CO, Summer 2005. |
R828610 (Final) |
not available |
| Dissertation/Thesis | Hemoglobin adducts as biomarkers of exposure to chlorotriazines. | None | Prentiss P | Prentiss P. Hemoglobin adducts as biomarkers of exposure to chlorotriazines. M.S. Thesis. Department of Environmental and Radiological Health Sciences, Colorado State University, Ft. Collins, CO, Summer 2004. |
R828610 (Final) |
not available |
| Journal Article | Family approach for estimating reference concentrations/doses for series of related organic chemicals. | TOXICOLOGICAL SCIENCES | Barton HA, Deisinger PJ, English JC, Gearhart JM, Faber WD, Tyler TR, Banton MI, Teeguarden J, Andersen ME | Barton HA, Deisinger PJ, English JC, Gearhart JM, Faber WD, Tyler TR, Banton MI, Teeguarden J, Andersen ME. Family approach for estimating reference concentrations/doses for series of related organic chemicals. Toxicological Sciences 2000;54(1):251-261. |
R828610 (2001) R828610 (Final) |
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| Journal Article | Quantitative identification of atrazine and its chlorinated metabolites in plasma. | JOURNAL OF ANALYTICAL TOXICOLOGY | Brzezicki JM, Andersen ME, Cranmer BK, Tessari JD | Brzezicki JM, Andersen ME, Cranmer BK, Tessari JD. Quantitative identification of atrazine and its chlorinated metabolites in plasma. Journal of Analytical Toxicology 2003;27(8):569-573. |
R828610 (2001) R828610 (2002) R828610 (Final) |
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| Journal Article | Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine. | CHEMICAL RESEARCH IN TOXICOLOGY | Dooley GP, Prenni JE, Prentiss PL, Cranmer BK, Andersen ME, Tessari JD | Dooley GP, Prenni JE, Prentiss PL, Cranmer BK, Andersen ME, Tessari JD. Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine. Chemical Research in Toxicology 2006;19(5):692-700. |
R828610 (Final) |
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| Journal Article | Pharmacokinetic modeling of disposition and time-course studies with [14C] atrazine. | JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A | McMullin TS, Brzezicki J, Cranmer B, Tessari J, Andersen M | McMullin TS, Brzezicki J, Cranmer B, Tessari J, Andersen M. Pharmacokinetic modeling of disposition and time-course studies with [14C] atrazine. Journal of Toxicology and Environmental Health-Part A 2003;66(10):941-964. |
R828610 (2001) R828610 (2002) R828610 (Final) |
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| Journal Article | Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action. | TOXICOLOGICAL SCIENCES | McMullin TS, Andersen ME, Nagahara A, Lund TD, Pak T, Handa RJ, Hanneman WH | McMullin TS, Andersen ME, Nagahara A, Lund TD, Pak T, Handa RJ, Hanneman WH. Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action. Toxicological Sciences 2004;79(2):278-286. |
R828610 (2003) R828610 (Final) |
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| Journal Article | Estimating constants for metabolism of atrazine in freshly isolated rat hepatocytes by kinetic modeling. | TOXICOLOGY IN VITRO | McMullin TS, Andersen ME, Tessari JD, Cranmer B, Hanneman WH | McMullin TS, Andersen ME, Tessari JD, Cranmer B, Hanneman WH. Estimating constants for metabolism of atrazine in freshly isolated rat hepatocytes by kinetic modeling. Toxicology in Vitro 2007;21(3):492-501. |
R828610 (Final) |
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| Journal Article | Gas chromatographic determination of catecholestrogens following isolation by solid-phase extraction. | JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES AND APPLICATIONS | Pinnella KD, Cranmer BK, Tessari JD, Cosma GN, Veeramachaneni DNR | Pinnella KD, Cranmer BK, Tessari JD, Cosma GN, Veeramachaneni DNR. Gas chromatographic determination of catecholestrogens following isolation by solid-phase extraction. Journal of Chromatography B: Biomedical Sciences and Applications 2001;758(2):145-152. |
R828610 (2001) R828610 (Final) |
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| Presentation | Introduction to toxicokinetics and applications in chemical risk assessment. | None | Andersen ME | Andersen ME. Introduction to toxicokinetics and applications in chemical risk assessment. Presented at the International Workshop on the Application of Physiological Toxicokinetic Modeling for Health Hazard Assessment of Chemical Substances, Munich, Germany, October 11-12, 2001. |
R828610 (2001) R828610 (Final) |
not available |
| Presentation | Chlorotriazine Protein Binding: Biomarkers of Exposure and Susceptibility. | None | Andersen ME, Tessari JD | Andersen ME, Tessari JD. Chlorotriazine Protein Binding: Biomarkers of Exposure and Susceptibility. Presented at the U.S. Environmental Protection Agency Human Health Symposium-A Science To Achieve Results (STAR) Progress Review Workshop, Washington, DC, April 9-10, 2003. |
R828610 (2002) |
not available |
| Presentation | Neuroendocrine effects of atrazine: assessing internal dose and mode of action. | None | Andersen ME | Andersen ME. Neuroendocrine effects of atrazine: assessing internal dose and mode of action. Presented to the Syngenta Corporation, Fall 2002. |
R828610 (2001) R828610 (Final) |
not available |
| Presentation | A biological-based risk assessment for vinyl acetate-induces cancer and non-cancer inhalation toxicity. | None | Bogdanffy MS, Sarangapani R, Plowchalk DR, Jarabek A, Andersen ME | Bogdanffy MS, Sarangapani R, Plowchalk DR, Jarabek A, Andersen ME. A biological-based risk assessment for vinyl acetate-induces cancer and non-cancer inhalation toxicity. Presented at the 40th Annual Meeting of the Society of Toxicology, San Francisco, CA, March 25-29, 2001. |
R828610 (Final) |
not available |
| Presentation | Assessing dose-dependent GSH depletion and chlorotriazine metabolite disposition after atrazine treatment with a physiological model. | None | Brzesicki (Ruble) JM, McMullin TS, Andersen ME | Brzesicki (Ruble) JM, McMullin TS, Andersen ME. Assessing dose-dependent GSH depletion and chlorotriazine metabolite disposition after atrazine treatment with a physiological model. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R828610 (2001) R828610 (Final) |
not available |
| Presentation | Chlorotriazine kinetics in female rats following a single oral gavage dose of atrazine or its chlorinated metabolites. | None | Brzezicki J, Cranmer BK, Tessari JD, Andersen ME | Brzezicki J, Cranmer BK, Tessari JD, Andersen ME. Chlorotriazine kinetics in female rats following a single oral gavage dose of atrazine or its chlorinated metabolites. Presented at the 42nd Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2003. |
R828610 (2002) R828610 (Final) |
not available |
| Presentation | Detection of atrazine and its chlorinated metabolites in plasma. | None | Brzezicki J | Brzezicki J. Detection of atrazine and its chlorinated metabolites in plasma. Presented to the Toxicology Section at Colorado State University, Fort Collins, CO, Spring 2002. |
R828610 (2001) |
not available |
| Presentation | Quantitative identification of atrazine and chlorinated metabolites from plasma isolated from whole rat blood utilizing GC/MS/SIM. | None | Cranmer BK, Brzesicki JM, Andersen ME, Tessari JD | Cranmer BK, Brzesicki JM, Andersen ME, Tessari JD. Quantitative identification of atrazine and chlorinated metabolites from plasma isolated from whole rat blood utilizing GC/MS/SIM. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R828610 (2001) R828610 (Final) |
not available |
| Presentation | Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine. | None | Dooley GP | Dooley GP. Identification of a novel hemoglobin adduct in Sprague Dawley rats exposed to atrazine. Presented at the U.S. Environmental Protection Agency Human Health Symposium-A Science to Achieve Results Progress Review Workshop, Philadelphia, PA, October 28-29, 2004. |
R828610 (2003) R828610 (Final) |
not available |
| Presentation | Effect of atrazine on the estrogen and progesterone induced luteinizing hormone surge and GNRH neuronal activity. | None | McMullin TS, Handa RJ, Hanneman WH, Andersen ME | McMullin TS, Handa RJ, Hanneman WH, Andersen ME. Effect of atrazine on the estrogen and progesterone induced luteinizing hormone surge and GNRH neuronal activity. Presented at the 42nd Annual Meeting of the Society of Toxicology, Salt Lake City, UT, March 9-13, 2003. |
R828610 (2002) R828610 (Final) |
not available |
| Presentation | The effects of atrazine on the ability of estradiol to bind to estrogen receptor in the hypothalamus. | None | McMullin TS, Nagahara AH, Handa RJ, Andersen ME | McMullin TS, Nagahara AH, Handa RJ, Andersen ME. The effects of atrazine on the ability of estradiol to bind to estrogen receptor in the hypothalamus. Presented at the 41st Annual Meeting of the Society of Toxicology, Nashville, TN, March 17-21, 2002. |
R828610 (2001) R828610 (Final) |
not available |
| Presentation | Detection of atrazine and its chlorinated metabolites in plasma. | None | Tessari JD | Tessari JD. Detection of atrazine and its chlorinated metabolites in plasma. Presented at the Toxicology Symposium, Colorado State University, Ft. Collins, CO, Spring 2002. |
R828610 (Final) |
not available |
| Presentation | Analytical determination of atrazine and its chlorinated metabolites in urine. | None | Tessari JD | Tessari JD. Analytical determination of atrazine and its chlorinated metabolites in urine. Presented at the National Symposium on Agricultural Health and Safety, National Institute for Occupational Safety and Health, North American Agromedicine Consortium, National Institute for Farm Safety, Keystone, CO, June 20-24, 2004. |
R828610 (Final) |
not available |
| Presentation | Analytical determination of atrazine and its major metabolites in urine. | None | Tessari JD | Tessari JD. Analytical determination of atrazine and its major metabolites in urine. Presented at the Undergraduate Research Showcase, Colorado State University, CO, May 2004. |
R828610 (Final) |
not available |
| Presentation | Development of novel biomarkers for pesticides in Region 8. | None | Tessari JD | Tessari JD. Development of novel biomarkers for pesticides in Region 8. Presented at the Joint Centers Meeting, Tyler, TX, April 28-29, 2005. |
R828610 (2004) |
not available |
| Presentation | Participated in the Centers for Disease Control/National Institute for Occupational Safety and Health Special Emphasis Panel: Occupational Exposure Risk on Reproductive Development | None | Tessari JD | Tessari JD. Participated in the Centers for Disease Control/National Institute for Occupational Safety and Health Special Emphasis Panel: Occupational Exposure Risk on Reproductive Development, Atlanta, GA, March 23, 2005. |
R828610 (2004) |
not available |
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.