Publications Details for:

Genetic Susceptibility
Grant Number R834514C004
RFA: Children's Environmental Health and Disease Prevention Research Centers (with NIEHS) (2009)
Book Chapter (1)
Journal Article (36)
Presentation (18)
Reference Type Citation Progress Report Year Document Sources
Book Chapter Costa LG, Cole TB, Furlong CE. Paraoxonase (PON1) and detoxication of nerve agents. In: Gupta R, ed. Handbook of Toxicology of Chemical Warfare Agents, Second Edition. New York, NY: Elsevier, January 21, 2015, Chapter 73, pp. 1089-1098. R834514 (2015)
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R834514C003 (2015)
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Journal Article Cole TB, Jansen K, Park S, Li W-F, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. Advances in Experimental Medicine and Biology 2010;660:47-60. R831709 (2007)
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Journal Article Giordano G, Tait L, Furlong CE, Cole TB, Kavanagh TJ, Costa LG. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radical Biology and Medicine 2013;58:98-108. R834514 (2013)
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Journal Article Inoue S, Becker AL, Kim J-H, Shu Z, Soelberg SD, Weigel KM, Hiraiwa M, Cairns A, Lee H-B, Furlong CE, Oh K, Lee K-H, Gao D, Chung J-H, Cangelosi GA. Semi-automated, occupationally safe immunofluorescence microtip sensor for rapid detection of mycobacterium cells in sputum. PLoS One 2014;9(1):e86018. R834514 (Final)
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Journal Article Kim DS, Marsillach J, Furlong CE, Jarvik GP. Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease. Pharmacogenomics 2013;14(12):1495-1515. R834514 (2013)
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Journal Article Kim DS, Burt AA, Rosenthal EA, Ranchalis JE, Eintracht JF, Hatsukami TS, Furlong CE, Marcovina S, Albers JJ, Jarvik GP. HDL-3 is a superior predictor of carotid artery disease in a case-control cohort of 1725 participants. Journal of the American Heart Association 2014;3(3):e000902. R834514 (Final)
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Journal Article Kim DS, Crosslin DR, Auer PL, Suzuki SM, Marsillach J, Burt AA, Gordon AS, Meschia JF, Nalls MA, Worrall BB, Longstreth Jr. WT, Gottesman RF, Furlong CE, Peters U, Rich SS, Nickerson DA, Jarvik GP. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. Journal of Lipid Research 2014;55(6):1173-1178. R834514 (Final)
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Journal Article Kim DS, Burt AA, Ranchalis JE, Jarvik LE, Eintracht JF, Furlong CE, Jarvik GP. Effects of dietary components on high-density lipoprotein measures in a cohort of 1,566 participants. Nutrition & Metabolism 2014;11(1):44 (9 pp.). R834514C004 (2015)
Journal Article Kim DS, Burt AA, Ranchalis JE, Vuletic S, Vaisar T, Li WF, Rosenthal EA, Dong W, Eintracht JF, Motulsky AG, Brunzell JD, Albers JJ, Furlong CE, Jarvik GP. PLTP activity inversely correlates with CAAD: effects of PON1 enzyme activity and genetic variants on PLTP activity. Journal of Lipid Research 2015;56(7):1351-1362. R834514 (Final)
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Journal Article Marsillach J, Costa LG, Furlong CE. Protein adducts as biomarkers of exposure to organophosphorus compounds. Toxicology 2013;307:46-54. R834514 (2013)
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Journal Article Marsillach J, Suzuki SM, Richter RJ, McDonald MG, Rademacher PM, MacCoss MJ, Hsieh EJ, Rettie AE, Furlong CE. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One 2014;9(10):e110054. R834514 (Final)
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Journal Article Marsillach J, Becker JO, Vaisar T, Hahn BH, Brunzell JD, Furlong CE, deBoer IH, McMahon MA, Hoofnagle AN, DCCT/EDIC Research Group. Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis. Journal of Proteome Research 2015;14(5):2046-2054. R834514 (Final)
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Journal Article Mehta AJ, Zanobetti A, Bind MA, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. Long-term exposure to ambient fine particulate matter and renal function in older men: the Veterans Administration Normative Aging Study. Environmental Health Perspectives 2016;124(9):1353-1360. R834514C004 (Final)
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Journal Article Marsillach, J., E.J. Hsieh, R.J. Richter, M.J. Maccoss, and C.E. Furlong, Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact, 2012. R834514C004 (Final)
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Journal Article Kim, DS, Crosslin, DR, Auer, PL, Suzuki, SM, Marsillach, J, Burt, AA, Gordon, AS, Meschia, JF, Nalls, MA, Worrall, BB, Longstreth, WT, Jr., Gottesman, RF, Furlong, CE, Peters, U, Rich, SS, Nickerson, DA and Jarvik, GP. 2014. Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res. 55(6):1173-1178. 4031948. R834514C004 (Final)
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Journal Article Guizzetti, M., N.H. Moore, G. Giordano, K.L. VanDeMark, and L.G. Costa, Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors. Glia, 2010. 58(12):p. 1395-406. PMCID2925144. R834514C004 (Final)
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Journal Article Richter RJ, Jarvik GP, Furlong CE. 2010. Paraoxonase 1 (PON1) Status as a Risk Factor for Disease or Exposure. Adv Exp Med Biol 660:29-35. PMID 20221868. DOI 10.1007/978-1-60761-350-3_. NIHMSID #193805. R834514C004 (Final)
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Journal Article Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong, CE. 2010. Engineering Human PON1 in an E. coli Expression System. Adv Exp Med Biol.;660:37–45. http://doi.org/10.1007/978-1-60761-350-3_5. PMID 20221869. R834514C004 (Final)
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Journal Article Kim, DS, Burt, A, Ranchalis, J, Richter, RJ, Marshall, E, Rosenthal, E, Furlong, C and Jarvik, GP. 2012. Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids 2012:476316. PMCID:PMC3364586. R834514C004 (Final)
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Journal Article Cole, TB, Fisher, JC, Burbacher, TM, Costa, LG and Furlong, CE. 2012. Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol. 34(3):311-22. PMCID:PMC3367041. R834514C004 (Final)
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Journal Article Kim, DS, Burt, AA, Ranchalis, JE, Richter, RJ, Marshall, JK, Nakayama, KS, Jarvik, ER, Eintracht, JF, Rosenthal, EA, Furlong, CE and Jarvik, GP. 2012. Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res. 53(11):2450-8. PMCID:PMC3466014. R834514C004 (Final)
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Journal Article Costa, LG, Giordano, G, Cole, TB, Marsillach, J and Furlong, CE. 2013. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology. 307(10):115-122. PMCID:PMC3516631. R834514C004 (Final)
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Journal Article Costa, LG, Tait, L, de Laat, R, Dao, K, Giordano, G, Pellacani, C, Cole, TB and Furlong, CE. 2013. Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin:a mechanism of neuroprotection? Neurochem Res. 38(9):1809-18. 3735620. R834514C004 (Final)
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Journal Article Costa, LG, de Laat, R, Dao, K, Pellacani, C, Cole, TB and Furlong, CE. 2013. Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection. Neurotoxicology. 3942372. R834514C004 (Final)
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Journal Article Kim, DS, Burt, AA, Crosslin, DR, Robertson, PD, Ranchalis, JE, Boyko, EJ, Nickerson, DA, Furlong, CE and Jarvik, GP. 2013. Novel common and rare genetic determinants of paraoxonase activity:FTO, SERPINA12, and ITGAL. J Lipid Res. 54(2):552-60. PMCID:PMC3588879. R834514C004 (Final)
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Journal Article Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Furlong, CE. 2013. Proteomic analysis of adducted butyrylcholinesterase for biomonitoring organophosphorus exposures. Chem Biol Interact 203(1):85-90. R834514C004 (Final)
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Journal Article Cole, TB, Li, WF, Co, AL, Hay, AM, MacDonald, JW, Bammler, TK, Farin, FM, Costa, LG and Furlong, CE. 2014. Repeated Gestational Exposure of Mice to Chlorpyrifos Oxon is Associated with Paraoxonase 1 (PON1)-Modulated Effects in Maternal and Fetal Tissues. Toxicol Sci. R834514C004 (Final)
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Journal Article Garrick JM, Dao K, de Laat R, Elsworth J, Cole TB, Marsillach J, Furlong CE, Costa LG. 2016. Developmental expression of paraoxonase 2. Chem Biol Interact. pii:S0009-2797(16)30116-8. doi:10.1016/j.cbi.2016.04.001. PMID:27062895. R834514C004 (Final)
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Journal Article Marsillach J, Costa LG, Furlong CE. 2016. Paraoxonase-1 and Early-Life Environmental Exposures. Ann Glob Health. 82(1):100-10. PMID:27325068; PMCID:PMC4916371. R834514C004 (Final)
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Journal Article Furlong CE, Marsillach J, Jarvik GP, Costa LG. 2016. Paraoxonases-1,-2 and-3:What are their functions? Chem Biol Interact. doi:10.1016/j.cbi.2016.05.036. PMID:27238723. R834514C004 (Final)
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Journal Article Cole, T.B., J.C. Fisher, T.M. Burbacher, L.G. Costa, and C.E. Furlong, Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon. Neurotoxicol Teratol, 2012. 34(3):p. 311-322. R834514C004 (Final)
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Journal Article Burton C, Marsillach J, Zhang YS, Zhao W, Zheng X. Bioanalysis. 2015;7(13):1667-73. doi:10.4155/bio.15.90. Epub 2015 Jul 7** Judit Marsillach selected as a finalist for the Young Investigator Award to identify and reward promising early career researchers in the community. R834514C004 (Final)
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Journal Article Furlong, C.E., R.J. Richter, L.G. Costa, and G.P. Jarvik, Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics, in Chapter 9:Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. 2012, American Chemical Society:Available at:http://pubs.acs.org/doi/abs/10.1021/bk-2012-1099.ch009. p. 133-147. R834514C004 (Final)
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Journal Article Costa, L.G., G. Giordano, and C.E. Furlong, Pharmacological and dietary modulators of paraxonase 1 (PON1) activity and expression:the hunt goes on. Biochem Pharmacol, 2011. 81(3):p. 337-344. PMCID3077125. R834514C004 (Final)
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Journal Article Kim, D.S., A.A. Burt, J.E. Ranchalis, R.J. Richter, J.K. Marshall, K.S. Nakayama, E.R. Jarvik, J.F. Eintracht, E.A. Rosenthal, C.E. Furlong, and G.P. Jarvik, Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res, 2012. 53(11):p. 2450-8. R834514C004 (Final)
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Journal Article Kim, D.S., A. Burt, J. Ranchalis, R.J. Richter, E. Marshall, E. Rosenthal, C. Furlong, and G.P. Jarvik, Additional common polymorphisms in the PON gene cluster predict PON1 activity but not vascular disease. J Lipids, 2012. 2012(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364586/pdf/JL2012-476316.pdf). R834514C004 (Final)
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Journal Article Asselbergs, F.W., Y. Guo, E.P. van Iperen, S. Sivapalaratnam, V. et al. Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. Am J Hum Genet, 2012. 91(5):p. 823-38. R834514C004 (Final)
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Presentation Furlong CE, Li W-F, Cole TB, Beyer RP, Bammler TK, Park SS, Farin FM, Costa LG. Effects of paraoxonase-1 (PON1) status on pre-and postnatal exposures to chlorpyrifos oxon and diazoxon. Presented at the 38th Annual Meeting of the Neurobehavioral Teratology Society, Bellevue, WA, June 28-July 2, 2014 (invited). R834514 (2015)
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Presentation Furlong CE, Marsillach J. Biomarkers of organophosphate exposure. Presented at the Global Cabin Air Quality Executive Meeting, London, United Kingdom, February 25, 2015 (invited). R834514 (2015)
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Presentation Furlong CE. Your genome and its ability to modulate toxic exposures--some examples. Presented at the Bainbridge Island Women’s Club, Bainbridge Island, WA, January 15, 2015 (invited). R834514 (2015)
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Presentation Marsillach J, Hsieh EJ, Richter RJ, MacCoss MJ, Hoofnagle AN, Rettie AE, MacDonald MG, Furlong CE. Biomonitoring human organophosphorus exposures by mass spectrometry. Presented at the Association of Analytical Chemistry Accurate Mass Spectrometry Workshop, Tacoma, WA, June 18, 2014 (invited). R834514 (2015)
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Presentation Marsillach J, Hsieh EJ, Richter RJ, MacCoss MJ, Hoofnagle AN, Furlong CE. Use of dried blood spots and mass spectrometry for biomonitoring organophosphorus exposures. Poster presented at the 38th Annual Meeting of the Neurobehavioral Teratology Society, Bellevue, WA, June 28-July 2, 2014. R834514 (2015)
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Presentation Marsillach J, Hsieh EJ, Richter RJ, Suzuki SM, Bukowski TR, MacCoss MJ, Hoofnagle AN, Furlong CE. Biomarkers of organophosphorus exposures in humans--detection of insecticide exposures in humans. Poster presented at the Superfund Research Program Annual Meeting, San Jose, CA, November 12-14, 2014. R834514 (2015)
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Presentation Marsillach J, Furlong CE. Biomarkers of organophosphate exposure and cytochromes P450S. Presented at the Global Cabin Air Quality Executive Meeting, London, United Kingdom, February 25, 2015 (invited). R834514 (2015)
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Presentation Marsillach J. Adductomics and human exposome: monitoring exposures to organophosphates. Presented at Summer Talks in Neurotoxicology and Psychopharmacology, Reus, Spain, June 15-16, 2015 (invited). R834514 (Final)
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Presentation Marsillach J, Hsieh EJ, Richter RJ, Paulsen MH, Simpson CD, MacCoss MJ, Hoofnagle AN, Furlong CE. Adductomics and organophosphorus exposures in communities. Poster presented at the Superfund Research Program Annual Meeting, San Juan, Puerto Rico, November 18-20, 2015. R834514 (Final)
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Presentation Marsillach J, Hsieh EJ, Richter RJ, Suzuki SM, Bukowski TR, MacCoss MJ, Hoofnagle AN, Furlong CE. Proteomics characterization of biomarkers of organophosphorus exposure. Presented at the 12th International Meeting on Cholinesterases and 6th International Conference on Paraoxonases, Elche, Spain, September 27-30, 2015 (invited). R834514 (Final)
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Presentation Marsillach, J., E. Hsieh, R.J. Richter, M.J. MacCoss, D. Tomazela, M.H. Paulsen, C.D. Simpson, and C. Furlong. Poster:Mass spectrometric-based biomarker analysis of organophosphorus exposure in agricultural workers in Society of Toxicology Annual Meeting. 2012 March. San Francisco, CA. R834514C004 (Final)
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Presentation Furlong, C., R.J. Richter, W.F. Li, T.B. Cole, J. Marsillach, S.M. Suzuki, E.R. Jarvik, and L.G. Costa. Presentation:Plenary Lecture 1:Paraoxonase (PON1) Status and Modulation of the Toxicity of Specific Organophosphorus Compounds. in 5th International Conference on Paraoxonases. 2012 July. Columbus, OH. R834514C004 (Final)
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Presentation Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Hoofnagle, AN and Furlong, CE. 2013. Poster:Proteomics analysis of biomarkers of organophosphorus exposures. Scientific Session 3:Risks of Pollutants during Early Life Exposures. 2013 Superfund Research Annual Meeting, Baton Rouge, Louisiana(October 2013). R834514C004 (Final)
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Presentation Marsillach, J, Hsieh, EJ, Richter, RJ, MacCoss, MJ, Hoofnagle, AN and Furlong, CE. 2014. Poster:Proteomic analysis of dried blood spots for biomonitoring organophosphorus exposures. Society of Toxicology Annual Meeting. Phoenix, AZ. R834514C004 (Final)
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Presentation Engineering recombinant PON1s for increased catalytic efficiency of OP hydrolysis. Furlong CE, Bukowski TR, Suzuki SM, Marsillach J, Richter RJ, Costa LG. 12th International Meeting on Cholinesterases and 6th International Conference on Paraoxonases, September 27-30, 2015, Elche (Spain). INVITED SPEAKER. R834514C004 (Final)
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Presentation Giordano, G, Furlong, CE, Cole, TB and Costa, LG (2013:March). Poster:Estradiol Modulates Paraoxonase-2 Expression in Mouse Brain. Society of Toxicology Annual Meeting. San Antonio, TX. R834514C004 (Final)
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Presentation Cole, TB, Li, WF, Co, AL, Marsillach, J, Hay, AM, Richter, RJ, Costa, LG and Furlong, CE (2013:March). Presentation:Maternal Paraoxonase (PON1) Status Modulates Fetal Effects Associated with Gestational Exposure of Mice to Chlorpyrifos Oxon. Society of Toxicology Annual Meeting. San Antonio, TX. R834514C004 (Final)
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Presentation Furlong, C. Presentation:The Many Facets of Gene/Environment Interactions of the Paraoxonases. in NIEHS Keystone Lecture Series. 2012 September. Triangle Park, NC. R834514C004 (Final)
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