Publications Details for:

High-throughput Hazard,Dose-responseandPopulationVariabilityAssessmentofCardiotoxicity in aHumanInducedPluripotentStem Cell(iPSC)-derivedinvitro Culture Model
Grant Number R835802C001
RFA: Organotypic Culture Models for Predictive Toxicology Center (2013)
Journal Article (11)
Presentation (26)
Reference Type Citation Progress Report Year Document Sources
Journal Article Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA. Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. Clinical Pharmacology and Therapeutics 2019;105:1175-1186. R835802 (2018)
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Journal Article Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli G. Beyond the RfD:Broad application of a probabilistic approach to improve chemical dose-response assessments for noncancer effects. Environmental Health Perspective 2018;126(6):067009. R835802 (2018)
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Journal Article Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS. The next generation of risk assessment multi-year study--highlights of findings, applications to risk assessment, and future directions. Environmental Health Perspectives 2016;124(11):1671-1682. R835166 (Final)
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Journal Article Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, Miller A, Paoli G, Price P, Rhomberg L, Shen B, Shin HM, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE. Advancements in life cycle human exposure and toxicity characterization. Environmetnal Health Perspective 2018;126:125001. R835802 (2018)
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Journal Article Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Assay and Drug Development Technologies 2015;13(9):529-546. R835802 (2015)
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Journal Article Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, Rusyn I. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chemistry 2016;18(16):4407-4419. R835166 (Final)
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Journal Article Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. A human population-based organotypic in vitro model for cardiotoxicity screening. ALTEX 2018;35:441-452. R835802 (2018)
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Journal Article Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-Dimensional in Vitro Bioactivity Profiling for Grouping of Glycol Ethers. Regulatory Toxicology and Pharmacology 2019;101:91-102. R835166 (Final)
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Journal Article Konganti K, Ehrlich A, Rusyn I, Threadgill DW. gQTL:a web application for QTL analysis using the collaborative cross mouse genetic reference population. G3:Genes, Genomes, Genetics 2018;8(8):2559-2562 R835802 (2017)
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Journal Article Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics 2018;19(1):80 (7 pp.). R835802 (2017)
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Journal Article Hsieh NH, Reisfeld, B, Bois FY, Chiu WA. Applying a global sensitivity analysis workflow to improve the computational efficiencies in physiologically-based pharmacokinetic modeling. Frontiers in Pharmacology 2018 9:588. R835802 (2018)
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Presentation Chiu W. Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. Laboratory Animal Sciences Virtual Event. Online Conference by Labroots, Inc. February 2019. R835802 (2018)
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Presentation Grimm FA, Iwata Y, Sirenko O, Russell WK, Luo Y, Crittenden C, Wright FA, Reif DM, Yeakley J, Seligmann B, Shepard P, Roy T, Boogaard PJ, Ketelslegers H, Rohde AM, Rusyn I. Categorization of UVCBs using chemical-biological read across. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835166 (2016)
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Presentation Grimm F, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-content assay multiplexing for toxicity screening in induced pluripotent stem cell-derived cardiomyocytes and hepatocytes. Poster presented at the Society for Biomolecular Imaging and Informatics Annual Meeting, Boston, MA, September 15-17, 2015. R835802 (2016)
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Presentation Iwata Y, Grimm F, Wilson M, Bittner M, Sirenko O, Rowlands JC, Ball N, Rusyn I. Toxicological categorization of P-and E-series glycol ethers using high-content screening of human induced pluripotent stem cell (iPSC)-derived cells. Poster presented at the Society of Toxicology 55th Annual Meeting and ToxExpo, New Orleans, LA, March 13-17, 2016. R835166 (2016)
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Presentation Rusyn I. Mouse vs. Machine: Are animal studies being supplanted by computers? Society of Toxicology Annual Meeting, Baltimore, MD, March 2019. R835802 (2018)
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Presentation Wilson MR, Rowlands JC, Ball N, Wignall JA, Fourches D, Rusyn I. Data integration and visualization for transparent communication of the category read across: glycol ethers case study. Poster presented at the International Council of Chemical Associations’ Long-Range Research Initiative (ICCA-LRI) Workshop, New Orleans, LA, June 16-17, 2015. R835802 (2016)
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Presentation Chen Z, Yanagisawa L, Chiu WA, Rusyn I. A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. Presented at The Harvey Research Symposium, Corpus Christie, TX, 2018. R835802 (2018)
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Presentation Burnett S, Grimm F, Anson B, Wright FA, Chiu W, Rusyn I. An in vitro human population model for assessment of inter-individual variability in cardiotoxicity. Lone Star SOT Annual Meeting, Austin, TX, 2018. R835802 (2018)
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Presentation Chiu W. Application of the WHO-IPCS dose-response framework to the human toxicity component of life cycle impact analysis. Society for Risk Analysis Annual Meeting. Arlington, VA, December 2018. R835802 (2018)
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Presentation Chiu W. Beyond the RfD: Broad application of a probabilistic approach to improve chemical dose-response assessments for non-cancer effects. UC-SF Program on Reproductive Health and the Environment (PRHE) Rapid Response Network Meeting, November 2018. R835802 (2018)
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Presentation Chiu W. Development and use of quantitative adverse outcome pathways: lessons learned from application to cardiotoxicity. National Academies of Sciences Workshop: Strategies and tools for conducting systematic reviews of mechanistic data to support chemical assessments. Washington, DC, December 2018. R835802 (2018)
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Presentation Blanchette A, Grimm F, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Anson B, Rusyn I, Chiu WA. Thorough QT/QTC in a dish: An in vitro human model that accurately predicts clinical concentration-QTC relationships. Presented at the Lone Star SOT Annual Meeting, Austin, TX, 2018. R835802 (2018)
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Presentation Chiu W.Thorough QT/QTc in a dish: An in vitro human model that accurately predicts clinical concentration-QTc relationships. American Society for Cellular and Computational Toxicology webinar series, November 2018. R835802 (2018)
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Presentation Chiu W. Using ToxCast data in support of the key characteristics of carcinogens:opportunities and challenges. California EPA Cancer and Environmental Mixtures Meeting. Oakland, CA, August 2018. R835802 (2018)
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Presentation Chiu W. WHO/IPCS probabilistic approach to improve chemical dose-response assessments. Workshop on the Development of an Evidence Based Risk Assessment Framework. Ottawa, Canada, December 2018. R835802 (2018)
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Presentation Chen Z, Yanagisawa L, Liu Y, Camargo K, Casillas G, McDonald T, Horney J, Chiu WA, Rusyn I. A multi-tissue organotypic human in vitro model for rapid hazard identification of environmental chemicals and mixtures. Society of Toxicology Annual Meeting, Baltimore, MD 2019. R835802 (2018)
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Presentation Chiu W. Accurate clinical concentration-response predictions for cardiac arrhythmias using a population-based in vitro/in silico model. Department of Veterinary Physiology & Pharmacology Seminar. College Station, TX, February 2019. R835802 (2018)
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Presentation Burnett S, Blanchette A, Grimm F, Wright F, Chiu W, Rusyn I. Enabling Assessment of Cardiotoxicity Hazard for Environmental Chemicals Using An In Vitro Human Population Model. Society of Toxicology Annual Meeting, Baltimore, MD 2019. R835802 (2018)
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Presentation Reisfeld B, Chiu W, Hsieh N, Ghosh S, Olschanowsky C, Bois F. POPKAT: A Framework for Bayesian Population PBPK Analysis. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. R835802 (2018)
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Presentation Chiu W. Probabilistic Dose-Response Assessment Using the WHO/IPCS Framework. Training Workshop for California EPA/Department of Pesticide Regulation. Sacramento, CA, February 2019. R835802 (2018)
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Presentation Shao K, Chiu WA, Shapiro A. The Utility of Informative Prior in Benchmark Dose Modeling for Animal Reduction. Society of Toxicology Annual Meeting, Baltimore, MD, 2019. R835802 (2018)
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Presentation Chiu W. Thorough QT/QTc in a dish:An in vitro human model that accurately predicts clinical concentration-QTc relationships. Food and Drug Administration, Center for Drug Evaluation and Research, Pharmacology and Toxicology Reviewer Cardiac Journal Club, March 2019. R835802 (2018)
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Presentation Botta D, Popp J, Farris L, Van Ness KP, White CC, Kelly EJ, Faustman EM, Rusyn I, Threadgill D and Kavanagh TJ (2018). Initial Characterization of Hepatocytes Derived from Collaborative Cross Recombinant Inbred Mouse Strain iPSCs. Presented at the U.S EPA:3rd Annual STAR Organotypic Culture Models (OCM) Progress Review Meeting, Durham, NC. R835738C003 (2018)
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Presentation Hsieh, N., Chiu, W., and Reisfeld, B. Pksensi:An R Package to Apply Sensitivity Analysis in Pharmacokinetic Modeling. Society of Toxicology Annual Meeting, Baltimore, MD. 2019. R835802 (2019)
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Presentation Danforth, C., Craft, E., Bolden, A., Schultz, K., Kwiatkowski, C., Rusyn, I., and Chiu, W. Evidence integration across multiple toxicity endpoints to prioritize constituents of potential concern in oil and gas produced water. Society of Toxicology Annual Meeting, Baltimore, MD. 2019. R835802 (2019)
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Presentation House, J.S., Grimm, F.A., Jima, D., Rusyn, I.,Wright, F.A. High-Throughput Concentration Response Modeling in iPSC-Cardiomyocytes. Organotypic culture models annual STAR grantee meeting. Durham, NC. 2018. R835802 (2019)
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