Grantee Research Project Results
Methods for studying nonhuman primates in neurobehavioral toxicology and teratology.
Citation:
Burbacher TM, Grant KS. Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicology and Teratology 2000;22(4):475-486.
Abstract:
The behavioral repertoire of nonhuman primates is highly evolved and includes advanced problem-solving capabilities, complex social relationships, and sensory acuity equal or superior to humans. These factors make nonhuman primates valuable animal models for studies of the functional effects of neurotoxicants. This review provides descriptions of tests designed to study learning, memory, schedule-controlled behavior, information processing, social behavior, sensory functioning, and visual-motor coordination and/or visuospatial orientation in macaque monkeys. Whenever possible, the results of studies in primate behavioral toxicology are provided for individual test measures. The primate model is especially useful for studies of developmental exposures because monkeys, like humans, have relatively prolonged periods of gestation, infancy, and adolescence. In recognition of this, a special section is provided for tasks that are specifically designed to study behavioral processes in infant monkeys.The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.