Grantee Research Project Results
Journal Publications Details for Grant Number R826113
Synthetic Methodology "Without Reagents" Tandem Enzymatic and Electrochemical Methods for the Manufacturing of Fine Chemicals
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| Reference Type | Reference Title | Journal | Author | Citation | Progress Report Year | Document Sources |
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| Journal Article | (7R,8S,10bR)-7,8-dihydroxy-1,5,6,7,8,9,10,10b-octahydro-3H-1,3-oxazolo[4,3-a]isoquinolin-3-one. | ACTA CRYSTALLOGRAPHICA | Abboud KA, Butora G, Fearnley SP, Gum AG, Stabile MR, Hudlicky T | Abboud KA, Butora G, Fearnley SP, Gum AG, Stabile MR, Hudlicky T. (7R,8S,10bR)-7,8-Dihydroxy-1,5,6,7,8,9,10,10b-octahydro-3H-1,3-oxazolo[4,3-a]isoquinolin-3-one. Acta Crystallographica C-Crystal Structure Communications 1998;54(Pt 8):1162-1164. |
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| Journal Article | Total syntheses of ert-conduramine A and ent-7-deoxypancratistatin. | TETRAHEDRON LETTERS | Akgun H, Hudlicky T | Akgun H, Hudlicky T. Total syntheses of ert-conduramine A and ent-7-deoxypancratistatin. Tetrahedron Letters 1999;40(16):3081-3084. |
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| Journal Article | Intramolecular N-acyliminium ion-olefin cyclization in the synthesis of optically pure isoquinoline derivatives: control of stereochemistry and application to synthesis of morphine alkaloids. | COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | Bottari P, Endoma MA, Hudlicky T, Ghiviriga I, Abboud KA | Bottari P, Endoma MA, Hudlicky T, Ghiviriga I, Abboud KA. Intramolecular N-acyliminium ion-olefin cyclization in the synthesis of optically pure isoquinoline derivatives: control of stereochemistry and application to synthesis of morphine alkaloids. Collection of Czechoslovak Chemical Communications 1999;64(2):203-216. |
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| Journal Article | Inositol synthesis: concise preparation of L-chiro-inositol and muco-inositol from a common intermediate. | TETRAHEDRON: ASYMMETRY | Brammer Jr. LE, Hudlicky T | Brammer Jr. LE, Hudlicky T. Inositol synthesis: concise preparation of L-chiro-inositol and muco-inositol from a common intermediate. Tetrahedron-Asymmetry 1998;9(12):2011-2014. |
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| Journal Article | Direct biocatalytic synthesis of functionalized catechols: a "green" alternative to traditional methods with high effective mass yield. | GREEN CHEMISTRY | Bui VP, Hansen TV, Stenstrom Y, Hudlicky T | Bui VP, Hansen TV, Stenstrom Y, Hudlicky T. Direct biocatalytic synthesis of functionalized catechols: a green alternative to traditional methods with high effective mass yield. Green Chemistry 2000;2(6):263-265. |
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| Journal Article | A study of substrate specificity of toluene dioxygenase in processing aromatic compounds containing benzylic and/or remote chiral centers. | NEW JOURNAL OF CHEMISTRY | Bui VP, Hansen TV, Stenstrom Y, Hudlicky T, Ribbons DW | Bui VP, Hansen TV, Stenstrom Y, Hudlicky T, Ribbons DW. A study of substrate specificity of toluene dioxygenase in processing aromatic compounds containing benzylic and/or remote chiral centers. New Journal of Chemistry 2001;25(1):116-124. |
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| Journal Article | Toluene dioxygenase-mediated oxidation of aromatic substrates with remote chiral centers. | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | Bui V, Hansen TV, Stenstrom Y, Ribbons DW, Hudlicky T | Bui V, Hansen TV, Stenstrom Y, Ribbons DW, Hudlicky T. Toluene dioxygenase-mediated oxidation of aromatic substrates with remote chiral centers. Journal of the Chemical Society, Perkin Transactions 1 2000;(11):1669-1672. |
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| Journal Article | Toward a practical synthesis of morphine. The first several generations of a radical cyclization approach. | SYNTHESIS | Butora G, Hudlicky T, Fearnley SP, Stabile MR, Gum AG, Gonzalez D | Butora G, Hudlicky T, Fearnley SP, Stabile MR, Gum AG, Gonzalez D. Toward a practical synthesis of morphine. The first several generations of a radical cyclization approach. Synthesis-Stuttgart 1998;52(Suppl 1):665-681. |
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| Journal Article | Advanced intramolecular Diels-Alder study toward the synthesis of (-)-morphine: structure correction of a previously reported Diels-Alder product. | SYNTHESIS | Butora G, Gum AG, Hudlicky T, Abboud KA | Butora G, Gum AG, Hudlicky T, Abboud KA. Advanced intramolecular Diels-Alder study toward the synthesis of (-)-morphine: structure correction of a previously reported Diels-Alder product. Synthesis-Stuttgart 1998;52(3):275-278. |
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| Journal Article | Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. | JOURNAL OF MEDICINAL CHEMISTRY | Cheng M, De B, Almstead NG, Pikul S, Dowty ME, Dietsch CR, Dunaway CM, Gu F, Hsieh LC, Janusz MJ, Taiwo YO, Natchus MG, Hudlicky T, Mandel M | Cheng M, De B, Almstead NG, Pikul S, Dowty ME, Dietsch CR, Dunaway CM, Gu F, Hsieh LC, Janusz MJ, Taiwo YO, Natchus MG, Hudlicky T, Mandel M. Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. Journal of Medicinal Chemistry 1999;42(26):5426-5436. |
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| Journal Article | Synthesis and biological evaluation of conduritol and conduramine analogs. | JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | Desjardins M, Lallemand MC, Freeman S, Hudlicky T, Abboud KA | Desjardins M, Lallemand MC, Freeman S, Hudlicky T, Abboud KA. Synthesis and biological evaluation of conduritol and conduramine analogs. Journal of the Chemical Society, Perkin Transactions 1 1999;(5):621-628. |
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| Journal Article | The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene. | None | Eger II EI, Halsey MJ, Koblin DD, Laster MJ, Ionescu P, Konigsberger K, Fan R, Nguyen BV, Hudlicky T | Eger II EI, Halsey MJ, Koblin DD, Laster MJ, Ionescu P, Konigsberger K, Fan R, Nguyen BV, Hudlicky T. The convulsant and anesthetic properties of cis-trans isomers of 1,2-dichlorohexafluorocyclobutane and 1,2-dichloroethylene. Anesthesia and Analgesia 2001;93(4):922-927. |
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| Journal Article | Model study for a general approach to morphine and noroxymorphone via a rare Heck cyclization. | ORGANIC LETTERS | Frey DA, Duan C, Hudlicky T | Frey DA, Duan C, Hudlicky T. Model study for a general approach to morphine and noroxymorphone via a rare Heck cyclization. Organic Letters 1999;1(13):2085-2087. |
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| Journal Article | Comparison of approaches to ent-morphine via radical, cationic, and Heck-type cyclizations. | COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | Frey DA, Duan C, Ghiviriga I, Hudlicky T | Frey DA, Duan C, Ghiviriga I, Hudlicky T. Comparison of approaches to ent-morphine via radical, cationic, and Heck-type cyclizations. Collection of Czechoslovak Chemical Communications 2000;65(4):561-569. |
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| Journal Article | Elucidation of the stereochemistry of octahydroisoquinoline derivatives by NMR spectroscopy. | MAGNETIC RESONANCE IN CHEMISTRY | Ghiviriga I, Bottari PQ, Hudlicky T | Ghiviriga I, Bottari PQ, Hudlicky T. Elucidation of the stereochemistry of octahydroisoquinoline derivatives by NMR spectroscopy. Magnetic Resonance in Chemistry 1999;37(9):653-661. |
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| Journal Article | A short chemoenzymatic synthesis of (+)-narciclasine. | TETRAHEDRON LETTERS | Gonzalez D, Martinot TA, Hudlicky T | Gonzalez D, Martinot TA, Hudlicky T. A short chemoenzymatic synthesis of (+)-narciclasine. Tetrahedron Letters 1999;40(16):3077-3080. |
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| Journal Article | New metabolites from the microbial oxidation of fluorinated aromatic compounds. | JOURNAL OF FLUORINE CHEMISTRY | Hudlicky T, Gonzalez D, Stabile MR, Endoma MA, Deluca M, Parker D, Gibson DT, Resnick SM, Whited GM | Hudlicky T, Gonzalez D, Stabile M, Endoma MA, Deluca M, Parker D, Gibson DT, Resnick SM, Whited GM. New metabolites from the microbial oxidation of fluorinated aromatic compounds. Journal of Fluorine Chemistry 1998;89(1):23-30. |
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| Journal Article | Natural product synthesis via biocatalysis: an essay on the merits of multidisciplinary ventures. | JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | Hudlicky T | Hudlicky T. Natural product synthesis via biocatalysis: an essay on the merits of multidisciplinary ventures. Journal of the Brazilian Chemical Society 1998;9(4):313-318. |
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| Journal Article | Toward a 'reagent-free' synthesis. | GREEN CHEMISTRY | Hudlicky T, Frey DA, Koroniak L, Claeboe CD, Brammer LE | Hudlicky T, Frey DA, Koroniak L, Claeboe CD, Brammer Jr. LE. Toward a 'reagent-free' synthesis. Green Chemistry 1999;1(2):57-59. |
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| Journal Article | The use of electrochemical methods as an alternative to tin reagents for the reduction of vinyl halides in inositol synthons. | JOURNAL OF ORGANIC CHEMISTRY | Hudlicky T, Claeboe CD, Brammer Jr. LE, Koroniak L, Butora G, Ghiviriga I | Hudlicky T, Claeboe CD, Brammer Jr. LE, Koroniak L, Butora G, Ghiviriga I. Use of electrochemical methods as an alternative to tin reagents for the reduction of vinyl halides in inositol synthons. Journal of Organic Chemistry 1999;64(13):4909-4913. |
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| Journal Article | 1-Chloro-(2S,3S)-dihydroxycyclohexa-4,6-diene. | ORGANIC SYNTHESES | Hudlicky T, Stabile MR, Gibson DT, Whited GM | Hudlicky T, Stabile MR, Gibson DT, Whited GM. 1-Chloro-(2S,3S)-dihydroxycyclohexa-4,6-diene. Organic Syntheses 1999;76:77-85. |
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| Journal Article | Enzymatic dihydroxylation of aromatics in enantioselective synthesis: expanding asymmetric methodology. | ALDRICHIMICA ACTA | Hudlicky T, Gonzalez D, Gibson DT | Hudlicky T, Gonzalez D, Gibson DT. Enzymatic dihydroxylation of aromatics in enantioselective synthesis: expanding asymmetric methodology. Aldrichimica Acta 1999;32(2):35-62. |
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| Journal Article | A short, stereoselective synthesis of neo-inositol. | CARBOHYDRATE RESEARCH | Hudlicky T, Restrepo-Sanchez NE, Kary PD, Jaramillo-Gomez LM | Hudlicky T, Restrepo-Sanchez NE, Kary PD, Jaramillo-Gomez LM. A short, stereoselective synthesis of neo-inositol. Carbohydrate Research 2000;324(3):200-203. |
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| Journal Article | Asymmetric synthesis-preface | CURRENT ORGANIC CHEMISTRY | Hudlicky T | Hudlicky T. Asymmetric synthesis-preface. Current Organic Chemistry 2000;4(3):i-ii. |
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| Journal Article | Recent progress in efficient syntheses of amaryllidaceae and morphine alkaloids. | JOURNAL OF HETEROCYCLIC CHEMISTRY | Hudlicky T | Hudlicky T. Recent progress in efficient syntheses of amaryllidaceae and morphine alkaloids. Journal of Heterocyclic Chemistry 2000;37(3):535-539. |
R826113 (Final) |
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| Journal Article | Chemoenzymatic synthesis of functionalized cyclohexylglycines and α-methylcyclohexylglycines via Kazmaier–Claisen rearrangement. | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Hudlicky T, Oppong KA, Duan C, Stanton C, Laufersweiler MJ, Natchus MG | Hudlicky T, Oppong KA, Duan C, Stanton C, Laufersweiler MJ, Natchus MG. Chemoenzymatic synthesis of functionalized cyclohexylglycines and α-methylcyclohexylglycines via Kazmaier–Claisen rearrangement. Bioorganic & Medicinal Chemistry Letters 2001;11(5):627-629. |
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| Journal Article | Asymmetric synthesis-preface. | CURRENT ORGANIC CHEMISTRY | Hudlicky T | Hudlicky T. Asymmetric synthesis-preface. Current Organic Chemistry 1998;2(3):U2-U3. |
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| Journal Article | New arene cis-dihydrodiol metabolites from β-bromostyrenes. | TETRAHEDRON: ASYMMETRY | Novak BH, Hudlicky T | Novak BH, Hudlicky T. New arene cis-dihydrodiol metabolites from β-bromostyrenes. Tetrahedron-Asymmetry 1999;10(11):2067-2069. |
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| Journal Article | Morphine synthesis and biosynthesis-an update. | CURRENT ORGANIC CHEMISTRY | Novak BH, Hudlicky T, Reed JW, Mulzer J, Trauner D | Novak BH, Hudlicky T, Reed JW, Mulzer J, Trauner D. Morphine synthesis and biosynthesis-an update. Current Organic Chemistry 2000;4(3):343-362. |
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| Journal Article | Chemoenzymatic enantiodivergent synthesis of 1,2-dideoxy-2-amino-1-fluoro-allo-inositol. | TETRAHEDRON | Oppong KA, Hudlicky T, Yan F, York C, Nguyen BV | Oppong KA, Hudlicky T, Yan F, York C, Nguyen BV. Chemoenzymatic enantiodivergent synthesis of 1,2-dideoxy-2-amino-1-fluoro-allo-inositol. Tetrahedron 1999;55(10):2875-2880. |
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| Journal Article | Novel O-and N-linked inositol oligomers: a new class of unnatural saccharide mimics. | SYNTHESIS-STUTTGART | Paul BJ, Martinot TA, Willis J, Hudlicky T | Paul BJ, Martinot TA, Willis J, Hudlicky T. Novel O-and N-linked inositol oligomers: a new class of unnatural saccharide mimics. Synthesis-Stuttgart 2001;(6):952-956. |
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| Journal Article | Electron transfer catalyzed [2 + 2] cycloreversion of benzene dimers. | JOURNAL OF ORGANIC CHEMISTRY | Reddy GD, Wiest O, Hudlicky T, Schapiro V, Gonzalez D | Reddy GD, Wiest O, Hudlicky T, Schapiro V, Gonzalez D. Electron transfer catalyzed [2 + 2] cycloreversion of benzene dimers. Journal of Organic Chemistry 1999;64(8):2860-2863. |
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| Journal Article | Free radical cyclizations of trienes with tris(trimethylsilyl)silane. | SYNTHETIC COMMUNICATIONS | Restrepo-Sanchez NE, Gomez FJ, Jaramillo-Gomez LM, Hudlicky T | Restrepo-Sanchez NE, Gomez FJ, Jaramillo-Gomez LM, Hudlicky T. Free radical cyclizations of trienes with tris(trimethylsilyl)silane. Synthetic Communications 1999;29(16):2795-2806. |
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| Journal Article | Structure assignment of aminoconduritols by 15N NMR correlation spectroscopy; synthesis of a positional isomer of 7-deoxypancratistatin. | CANADIAN JOURNAL OF CHEMISTRY | Schilling S, Rinner U, Chan C, Ghiviriga I, Hudlicky T | Schilling S, Rinner U, Chan C, Ghiviriga I, Hudlicky T. Structure assignment of aminoconduritols by 15N NMR correlation spectroscopy; synthesis of a positional isomer of 7-deoxypancratistatin. Canadian Journal of Chemistry 2001;79(11):1659-1667. |
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| Journal Article | Selective electrochemical reduction of cinnamyl ethers in the presence of other allylic C–O bonds. | TETRAHEDRON LETTERS | Solis-Oba A, Hudlicky T, Koroniak L, Frey D | Solis-Oba A, Hudlicky T, Koroniak L, Frey D. Selective electrochemical reduction of cinnamyl ethers in the presence of other allylic C–O bonds. Tetrahedron Letters 2001;42(7):1241-1243. |
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| Journal Article | Intramolecular Diels-Alder cycloadditions of cis-cyclohexadienediols derived enzymatically from (2-azidoethyl)benzene. Construction of highly functionalized bridged isoquinoline synthons. | None | Zezula J, Hudlicky T, Ghiviriga I | Zezula J, Hudlicky T, Ghiviriga I. Intramolecular Diels-Alder cycloadditions of cis-cyclohexadienediols derived enzymatically from (2-azidoethyl)benzene. Construction of highly functionalized bridged isoquinoline synthons. Collection of Czechoslovak Chemical Communications 2001;66(8):1269-1286. |
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