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Grantee Research Project Results

Journal Publications Details for Grant Number R830683

Biomarkers of Human Exposure to Pesticides Utilizing a New PBPK/PD Model and Kinetic Data on Pesticide Metabolism in Humans

RFA: Issues in Human Health Risk Assessment (2001)

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Journal Article (4)
Reference Type Reference Title Journal Author Citation Progress Report Year Document Sources
Journal Article Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos TOXICOLOGY Ellison C, Smith J, Lein P, Olson J Ellison C, Smith J, Lein P, Olson J. Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. TOXICOLOGY 2011;287(1-3):137-144. R830683 (2005)
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Journal Article Human hepatic cytochrome P450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon DRUG METABOLISM AND DISPOSITION Ellison C, Tian Y, Knaak J, Kostyniak P, Olson J Ellison C, Tian Y, Knaak J, Kostyniak P, Olson J. Human hepatic cytochrome P450-specific metabolism of the organophosphorus pesticides methyl parathion and diazinon. DRUG METABOLISM AND DISPOSITION 2012;40(1):1-5. R830683 (2005)
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Journal Article Human hepatic cytochrome P450-specific metabolism of parathion and chlorpyrifos. DRUG METABOLISM AND DISPOSITION Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, Olson JR. Human hepatic cytochrome P450-specific metabolism of parathion and chlorpyrifos. Drug Metabolism and Disposition 2007;35(2):189-193. R830683 (2005)
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Journal Article Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. TOXICOLOGY Foxenberg RJ, Ellison CA, Knaak JB, Ma CX, Olson JR Foxenberg RJ, Ellison CA, Knaak JB, Ma CX, Olson JR. Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion. Toxicology 2011;285(1-2):57-66. R830683 (2005)
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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.

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