Grantee Research Project Results
Health Effects Institute (2010-2015)
EPA Grant Number: R834677Center: Health Effects Institute (Prior to 2000)
Center Director: Greenbaum, Daniel S.
Title: Health Effects Institute (2010-2015)
Investigators: Greenbaum, Daniel S.
Institution: Health Effects Institute
EPA Project Officer: Chung, Serena
Project Period: April 1, 2010 through March 31, 2015
Project Amount: $25,000,000
RFA: Health Effects Institute (2010) RFA Text | Recipients Lists
Research Category: Human Health , Air Quality and Air Toxics , Air
Objective:
The Health Effects Institute's (HEI) Board of Directors, chaired by Richard Celeste, consists of public figures in science and policy who are committed to the public-private partnership that is central to the HEI approach. The Institute's scientific work is overseen by two independent scientific committees. The Health Research Committee works with the Institute's scientific staff to develop and manage HEI's research program. The Health Review Committee which has no role in selecting or overseeing studies, works with the Institute's scientific staff to evaluate and interpret the results of HEI studies and related research. HEI's priorities for research and special reviews are guided by the five-year HEI Strategic Plan , which is reviewed and updated annually after consultations with HEI sponsors and other interested parties.
Approach:
HEI is also asked periodically to produce special reports reviewing an entire area of scientific literature on topics such as the health effects of exposure to traffic and air toxics.
To accomplish its mission, HEI:
- Identifies the highest priority areas for health effects research;
- Funds and oversees the conduct of high-quality research in these priority areas;
- Provides intensive, independent review of HEI-supported and related research;
- Integrates HEI’s research results with those of other institutions into coherent, broader evaluations of health effects; and
- Communicates the results of HEI research and analyses to public and private decision makers.
The HEI research program has addressed questions about the health effects associated with exposure to both regulated pollutants such as carbon monoxide, ozone, and nitrogen dioxide, and unregulated pollutants such as diesel exhaust, aldehydes, and methanol. HEI has also funded studies to understand the mechanisms of diseases, to develop better methods to assess health effects and determine dose response relationships. The program includes theoretical, in vitro, animal, controlled human exposure, and epidemiological studies.
Rationale:
HEI is an independent, nonprofit corporation chartered in 1980 to provide high-quality, impartial, and relevant science on the health effects air pollution. Supported jointly by the U.S. Environmental Protection Agency (EPA) and industry, HEI has funded more than 280 research projects, the results of which have informed decisions regarding carbon monoxide, air toxics, nitrogen oxides, diesel exhaust, ozone, particulate matter, and other pollutants. These results have appeared in the peer-reviewed literature and in more than 200 comprehensive reports published by HEI.
Expected Results:
The center is conducting research in a number of priority areas, including: new approaches to understanding exposure to and health effect of multiple pollutants )including particulate matter, gases, and air toxics; measuring health outcomes and benefits resulting from air quality actions; and assessing potential health consequences of new fuels and technology. Throughout its research HEI seeks to incorporate effects on sensitive subpopulations, development and validation of new scientific techniques, and providing public access to the data underlying its studies.
Journal Articles: 9 Displayed | Download in RIS Format
| Other center views: | All 17 publications | 10 publications in selected types | All 9 journal articles |
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Carone M, Dominici F, Sheppard L. In Pursuit of Evidence in Air Pollution Epidemiology:The Role of Causally Driven Data Science. EPIDEMIOLOGY 2020;31(1):1-6. |
R834677 (Final) |
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Choirat C, Braun D, Kioumourtzoghlou M. Data Science in Environmental Health Research. ENVIRONMENTAL EPIDEMIOLOGY 2019;6(13):291-299. |
R834677 (Final) |
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Matthaios V, Lawrence J, Martins M, Ferguson S, Wolfson J, Harrison R, Kourtrakis P. Quantifying factors affecting contributions of Roadway exhaust and non-exhaust emissions to ambient PM10-2.5 and PM2.5-0.2 particles. SCIENCE OF THE TOTAL ENVRIONMENT 2022;835. |
R834677 (Final) R835872 (2020) R835872C001 (Final) |
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Meng Q, Hackfeld LC, Hodge RP, Walker VE. Comparison of mutagenicity of stereochemical forms of 1,2,3,4-diepoxybutane at HPRT and TK loci in human cells. Environmental and Molecular Mutagenesis 2003;41(36 Supplement):77. |
R834677C150 (Final) |
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Meng Q, Redetzke DL, Hackfeld LC, Hodge RP, Walker DM, Walker VE. Mutagenicity of stereochemical configurations of 1,2-epoxybutene and 1,2:3,4-diepoxybutane in human lymphoblastoid cells. Chemico-Biological Interactions 2007;166(1-3):207-218. |
R834677C150 (Final) |
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Mork D, Braun D, Zanobetti A. Time-lagged relationships between a decade of air pollution exposure and first hospitalization with Alzheimer's disease and related dementias. ENVIRONMENTAL INTERNATIONAL 2023;171(107694) |
R834677 (Final) |
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Papadogeorgou G, Kioumourtzoglou M, Braun D, Zanobetti A. Low Levels of Air Pollution and Health:Effect Estimates, Methodological Challenges, and Future Directions. CURRENT ENVIRONMENTAL HEALTH REPORTS 2019;6(3):105-115. |
R834677 (Final) |
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Shi L, Wu X, Danesh Yazdi M, Braun D, Abu Awad Y, Wei Y, Liu P, Di Q, Wang Y, Schwartz J, Dominici F, Kioumourtzoglou M-A, Zanobetti A. Long-term effects of PM2·5 on neurological disorders in the American Medicare population:a longitudinal cohort study. The Lancet Planetary Health 2020; 4(12):e557-e565. |
R834677 (Final) R835872C003 (Final) |
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Wu X, Nethery RC, Sabath MB, Braun D, Dominici F. Air pollution and COVID-19 mortality in the United States:Strengths and limitations of an ecological regression analysis. Science Advances 2020; 6(45) |
R834677 (Final) R835872 (2020) R835872C004 (Final) |
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Supplemental Keywords:
Emmissions, Air Quality, Diesel, Health Effects, Carbon Monoxide, Ozone, Nitrogen Dioxide, Particulate Matter;Relevant Websites:
Health Effects Institute: April 1, 2000 through March 31, 2005
Health Effects Institute: April 1, 2005 through March 31, 2010
Research Centers - Health Effects Institute
http://www.healtheffects.org/ Exit
Progress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834677C149 Development and Application of a Sensitive Method to Determine Concentrations of Acrolein and Other Carbonyls in Ambient Air
R834677C150 Mutagenicity of Stereochemical Configurations of 1,3-Butadiene Epoxy Metabolites in Human Cells
R834677C151 Biologic Effects of Inhaled Diesel Exhaust in Young and Old Mice: A Pilot Project
R834677C152 Evaluating Heterogeneity in Indoor and Outdoor Air Pollution Using Land-Use Regression and Constrained Factor Analysis
R834677C153 Improved Source Apportionment and Speciation of Low-Volume Particulate Matter Samples
R834677C155 The Impact of the Congestion Charging Scheme on Air Quality in London
R834677C156 Concentrations of Air Toxics in Motor Vehicle-Dominated Environments
R834677C158 Air Toxics Exposure from Vehicle Emissions at a U.S. Border Crossing: Buffalo Peace Bridge Study
R834677C159 Role of Neprilysin in Airway Inflammation Induced by Diesel Exhaust Emissions
R834677C160 Personal and Ambient Exposures to Air Toxics in Camden, New Jersey
R834677C162 Assessing the Impact of a Wood Stove Replacement Program on Air Quality and Children’s Health
R834677C163 The London Low Emission Zone Baseline Study
R834677C165 Effects of Controlled Exposure to Diesel Exhaust in Allergic Asthmatic Individuals
R834677C168 Evaluating the Effects of Title IV of the 1990 Clean Air Act Amendments on Air Quality
R834677C172 Potential Air Toxics Hot Spots in Truck Terminals and Cabs
R834677C173 Detection and Characterization of Nanoparticles from Motor Vehicles
R834677C174 Cardiorespiratory Biomarker Responses in Healthy Young Adults to Drastic Air Quality Changes Surrounding the 2008 Beijing Olympics
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.