Grantee Research Project Results
2011 Progress Report: Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
EPA Grant Number: R834796C003Subproject: this is subproject number 003 , established and managed by the Center Director under grant R834796
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: University of Washington Center for Clean Air Research
Center Director: Vedal, Sverre
Title: Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
Investigators: Campen, Matthew J. , McDonald, Jacob D. , Lund, Amie K. , Rosenfeld, Michael
Institution: Lovelace Biomedical & Environmental Research Institute , University of Washington , University of New Mexico
Current Institution: Lovelace Biomedical & Environmental Research Institute , University of New Mexico , University of Washington
EPA Project Officer: Callan, Richard
Project Period: December 1, 2010 through November 30, 2015 (Extended to November 30, 2017)
Project Period Covered by this Report: December 1, 2010 through July 31,2011
RFA: Clean Air Research Centers (2009) RFA Text | Recipients Lists
Research Category: Human Health , Air
Objective:
Traffic-related emissions are associated with the incidence and progression of acute and chronic cardiovascular sequelae in human population studies. Such phenomena of near-roadway health effects have yet to be characterized toxicologically. Because of potentially complex confounding issues related to noise, socioeconomic status, ethnicity, etc., there is a need to better understand the biological underpinnings of the hypothesis that fresh mixtures of vehicular emissions have a more potent than expected impact on human health. We hypothesize that the complex mixtures produced by traffic are inherently more toxic due to the combined presence of both particulates and volatile organic emissions. Furthermore, we hypothesize that emissions-induced oxidation of certain endogenous phospholipids, presumably from the pulmonary surfactant, can stimulate the activity of immune cells through such receptors and in turn promote the invasion of existing vascular lesions. This project will use complex roadway mixtures as generated and characterized in the laboratory (Project 2) to pursue the following aims:
Progress Summary:
At present, we have ordered the first cohort of mice for exposures. We are planning to carry out the first profile of exposures, detailed in Aim 1, in July-September 2011.
The first pilot studies are slated to begin late July 2011, in which we will start assessing the interactions between vehicular source pollutants (gasoline and diesel engine emissions) in driving vascular oxidative stress. Three ratios of emission composition will be tested among two strains (ApoE-null and LDLR-null) of mice and two diets (high fat and normal). Results from these early studies will focus efforts for future work in Aims 2 and 3. All exposures will be carried out using standardized exposure protocols established in Project 2.
Future Activities:
To complete accelerated exposures pertaining to Aim 1, and the vascular injury assays from those exposed animals, and complete breeding of double knockout mice. Continue interactions with Projects 1 and 2 in refining the exposure conditions.
Journal Articles:
No journal articles submitted with this report: View all 26 publications for this subprojectSupplemental Keywords:
Coronary artery disease, oxidized phospholipids, atherosclerosis, particulate matter, volatile organic compounds, VOCs, carbon monoxide, ozone, toxicology, Scientific Discipline, Health, Air, ENVIRONMENTAL MANAGEMENT, Air Quality, air toxics, Health Risk Assessment, Risk Assessments, mobile sources, Environmental Monitoring, Biochemistry, Risk Assessment, ambient air quality, atmospheric particulate matter, particulate matter, aerosol particles, air pollutants, motor vehicle emissions, vehicle emissions, air quality models, motor vehicle exhaust, airway disease, bioavailability, air pollution, particle exposure, atmospheric aerosols, ambient particle health effects, vascular dysfunction, cardiotoxicity, atmospheric chemistry, exposure assessmentProgress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834796 University of Washington Center for Clean Air Research Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834796C001 Exposure Mapping – Characterization of Gases and Particles for ExposureAssessment in Health Effects and Laboratory Studies
R834796C002 Simulated Roadway Exposure Atmospheres for Laboratory Animal and Human Studies
R834796C003 Cardiovascular Consequences of Immune Modification by Traffic-Related Emissions
R834796C004 Vascular Response to Traffic-Derived Inhalation in Humans
R834796C005 Effects of Long-Term Exposure to Traffic-Derived Particles and Gases on Subclinical Measures of Cardiovascular Disease in a Multi-Ethnic Cohort
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2016 Progress Report
- 2015 Progress Report
- 2014
- 2013 Progress Report
- 2012 Progress Report
- Original Abstract
16 journal articles for this subproject
Main Center: R834796
196 publications for this center
92 journal articles for this center