Grantee Research Project Results
2012 Progress Report: Adolescent Exposure to BPA/Phthalates Cognitive and Behavioral Development
EPA Grant Number: R834593C002Subproject: this is subproject number 002 , established and managed by the Center Director under grant R834593
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Water Innovation Network for Sustainable Small Systems
Center Director: Reckhow, David A.
Title: Adolescent Exposure to BPA/Phthalates Cognitive and Behavioral Development
Investigators: Schantz, Susan L. , Korrick, Susan A. , Juraska, Janice , Gardiner, Joseph
Current Investigators: Korrick, Susan A.
Institution: University of Illinois Urbana-Champaign , Harvard University , Michigan State University
Current Institution: Harvard University
EPA Project Officer: Hahn, Intaek
Project Period: February 15, 2010 through February 14, 2014
Project Period Covered by this Report: February 15, 2012 through February 14,2013
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
The aim of this pilot project is to assess the relation of adolescent phthalate and bisphenol A (BPA) exposure with adolescent neurobehavior. The proposal builds on an ongoing study designed to assess the relation of early life organochlorine and metal exposures with subsequent development among 788 children followed since birth. Children participating in the parent study were born to mothers residing in towns adjacent to a Superfund site, the New Bedford Harbor, in New Bedford, MA. This pilot study takes advantage of the parent study's established infrastructure and rich data to address the following primary hypothesis: Adolescent exposure to phthalates and BPA (assessed as urine metabolite concentrations) are each independently associated with adolescent visual motor abilities, verbal abilities, working memory, and attention deficit hyperactivity disorder (ADHD)-related behaviors and psychiatric symptoms. As a secondary hypothesis, we will address the potential for phthalate or BPA associations with adolescent behavior and cognitive function to differ between boys and girls or by pubertal status.
Progress Summary:
Future Activities:
In the next funding period (no cost extension), we will complete urine (and urine questionnaire) collection on ~200 of the New Bedford Cohort children. Urines will be processed and stored, and questionnaire data entered and cleaned to complete our pilot work. Once this pilot data collection is complete, we anticipate doing analyses of the full cohort in a larger scale study funding for which currently is pending. In this planned full study, we will use comprehensive multivariable models to account for potential confounding and to assess reproducibility of our initial pilot findings.
Supplemental Keywords:
BPA, phthalates, adolescent health, children's health, behavior, cognition, RFA, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Children's Health, biological markersRelevant Websites:
Children's Environmental Health Research Center at Illinois Exit /
Progress and Final Reports:
Original AbstractMain Center Abstract and Reports:
R834593 Water Innovation Network for Sustainable Small Systems Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834593C001 Prenatal Exposure to BPA/Phthalates: Infant Physical and Behavioral Development
R834593C002 Adolescent Exposure to BPA/Phthalates Cognitive and Behavioral Development
R834593C003 Mechanisms of In Utero BPA Exposure on Fetal Gonad Development
R834593C004 Effects of Bisphenol A on the Developing Cortex
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.