Grantee Research Project Results
Formative Center for the Evaluation of Environmental Impacts on Fetal Development
EPA Grant Number: R834594Center: Formative Center for the Evaluation of Environmental Impacts on Fetal Development
Center Director: Boekelheide, Kim
Title: Formative Center for the Evaluation of Environmental Impacts on Fetal Development
Investigators: Boekelheide, Kim , De Paepe, Monique E , Thanos, Christopher , Phipps, Maureen , Brown, Phil , Gruppuso, Phillip , Kostadinov, Stephan
Current Investigators: Boekelheide, Kim , De Paepe, Monique E , Thanos, Christopher , Phipps, Maureen , Brown, Phil , Gruppuso, Phillip
Institution: Brown University , Thanos Scientific Consulting Group , Women & Infants Hospital of Rhode Island
Current Institution: Brown University , Women & Infants Hospital of Rhode Island
EPA Project Officer: Hahn, Intaek
Project Period: February 15, 2010 through February 14, 2014
Project Amount: $1,189,575
RFA: Children's Environmental Health and Disease Prevention Research Centers: Formative Centers (with NIEHS) (2009) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health
Objective:
This Formative Center for the Evaluation of Environmental Impacts on Fetal Development focuses on correlating morphological and molecular biomarkers with exposures to common environmental pollutants and stressors. There are three projects that will examine dysregulation of tissue differentiation and epigenetic programming by environmental agents:
- Research Project 1 —Liver and the Metabolic Syndrome is guided by the hypothesis that alterations in the intrauterine environment induce epigenetic changes in the developing liver that predispose to metabolic syndrome in the adult human.
- Research Project 2 —Prostate and Endocrine Disruption is guided by the hypothesis that estrogenic endocrine disrupting chemical exposures produce aberrant differentiation in the prostate due to altered DNA methylation.
- Research Project 3 —Lung, Arsenic Exposure, and Tissue Remodeling is guided by the hypothesis that arsenic exposure of cells in the developing lung results in disrupted postglandular lung remodeling mediated by molecular and epigenetic alterations.
The Administrative Core, the Community Outreach and Translation Core and the Pediatric Health Specialist will ensure that the Formative Center is responsive to both clinical and societal concerns associated with environmental exposures that impact growth and development. Drawing from many Departments (Community Health, Obstetrics & Gynecology, Pathology & Lab Medicine, Pediatrics, and Sociology) our goal is to use our cross-disciplinary integration to understand and resolve the inherently complex problems generated by intrauterine environmental exposures that can lead to later life disease. We also will translate our discoveries into clinically relevant outcomes, and share with university, hospital, and public audiences both these new insights and more general education on environmental public health.
Journal Articles: 8 Displayed | Download in RIS Format
Other center views: | All 13 publications | 8 publications in selected types | All 8 journal articles |
---|
Type | Citation | ||
---|---|---|---|
|
Boekelheide K, Blumberg B, Chapin RE, Cote I, Graziano JH, Janesick A, Lane R, Lillycrop K, Myatt L, States JC, Thayer KA, Waalkes MP, Rogers JM. Predicting later-life outcomes of early-life exposures. Environmental Health Perspectives 2012;120(10):1353-1361. |
R834594 (Final) R834594C002 (Final) |
|
|
De Paepe ME, Chu S, Hall S, Heger NE, Thanos C, Mao Q. The human fetal lung xenograft: validation as model of microvascular remodeling in the postglandular lung. Pediatric Pulmonology 2012;47(12):1192-1203. |
R834594 (2012) R834594 (Final) R834594C003 (Final) |
Exit |
|
De Paepe ME, Chu S, Heger N, Hall S, Mao Q. Resilience of the human fetal lung following stillbirth: potential relevance for pulmonary regenerative medicine. Experimental Lung Research 2012;38(1):43-54. |
R834594 (2012) R834594 (Final) R834594C003 (Final) |
Exit |
|
Heger NE, Hall SJ, Sandrof MA, McDonnell EV, Hensley JB, McDowell EN, Martin KA, Gaido KW, Johnson KJ, Boekelheide K. Human fetal testis xenografts are resistant to phthalate-induced endocrine disruption. Environmental Health Perspectives 2012;120(8):1137-1143. |
R834594 (Final) R834594C002 (Final) |
|
|
Panikkar B, Smith N, Brown P. Reflexive research ethics in fetal tissue xenotransplantation research. Accountability in Research 2012;19(6):344-369. |
R834594 (2012) R834594 (Final) |
Exit |
|
Saffarini CM, McDonnell EV, Amin A, Spade DJ, Huse SM, Kostadinov S, Hall SJ, Boekelheide K. Maturation of the developing human fetal prostate in a rodent xenograft model. The Prostate 2013;73(16):1761-1775. |
R834594 (2012) R834594 (Final) R834594C002 (Final) |
Exit |
|
Spade DJ, Hall SJ, Saffarini CM, Huse SM, McDonnell EV, Boekelheide K. Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay. Toxicological Sciences 2014;138(1):148-160. |
R834594 (Final) R834594C002 (Final) |
Exit Exit |
|
Thompson MR, Boekelheide K. Multiple environmental chemical exposures to lead, mercury and polychlorinated biphenyls among childbearing-aged women (NHANES 1999-2004): body burden and risk factors. Environmental Research 2013;121:23-30. |
R834594 (Final) |
Exit Exit Exit |
Supplemental Keywords:
in utero exposure, mammalian, metals, bisphenol A, developmental biology, perinatal programming; environmental management, Scientific Discipline, Health, Risk Assessment, Biology, Risk Assessments, Health Risk Assessment, bioavailability, exposure assessment, biochemical research, intrauterine exposure, developmental effects, perinatal exposure, children's health, biological pathways, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Risk Assessments, Biology, Risk Assessment, biological pathways, children's health, fetal exposure, bioavailability, developmental effects, perinatal exposure, biochemical researchProgress and Final Reports:
Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R834594C001 Liver and the Metabolic Syndrome
R834594C002 Prostate and Endocrine Disruption
R834594C003 Lung, Arsenic Exposure, and Tissue Remodeling
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.