Grantee Research Project Results
2013 Progress Report: Hypertension in Mexican-Americans: Assessing Disparities in Air Pollutant Risks
EPA Grant Number: R834581Title: Hypertension in Mexican-Americans: Assessing Disparities in Air Pollutant Risks
Investigators: Symanski, Elaine , Piller, Linda B. , Fernandez-Esquer, Maria E. , Bondy, Melissa L. , Chen, Lin-An , Chan, Wenyaw
Current Investigators: Symanski, Elaine , Bondy, Melissa L. , Chen, Lin-An , Jimenez, Maria , Strom, Sara , Chan, Wenyaw
Institution: The University of Texas School of Public Health , The University of Texas MD Anderson Cancer Center , National Chiao-Tung University
Current Institution: The University of Texas School of Public Health , National Chiao-Tung University , The University of Texas MD Anderson Cancer Center
EPA Project Officer: Hahn, Intaek
Project Period: August 1, 2010 through July 31, 2014 (Extended to July 31, 2016)
Project Period Covered by this Report: August 1, 2012 through July 31,2013
Project Amount: $1,250,000
RFA: Understanding the Role of Nonchemical Stressors and Developing Analytic Methods for Cumulative Risk Assessments (2009) RFA Text | Recipients Lists
Research Category: Human Health
Objective:
We are assessing the hypothesis that individual-and neighborhood-level psychosocial stressors exacerbate risks for hypertension associated with fine particulates and other air pollutants among individuals of Mexican origin living in Houston, Texas who are also participating in the University of Texas M.D. Anderson Cancer Center’s Mano a Mano cohort study. Several studies have shown an association between air pollutants and hypertension via oxidative stress and inflammatory pathways. Yet, little is known about the modifying effects of nonchemical stressors on air pollutant risks for hypertension. The incidence of hypertension, a key risk factor for cardiovascular diseases (CVD), has been growing in the United States (U.S.) and CVD remains the leading cause of death among the U.S. Hispanic population. Novel methods for addressing interactions in a logistic regression context are being developed. We are also applying a community-based approach by involving the community in defining research questions, identifying mechanisms for becoming involved in research activities and interpreting and disseminating research findings. This program will also help to identify culturally-specific elements that could be used for an effective intervention in a Latino community to address disparities in air pollutant health risks.
Progress Summary:
Future Activities:
We will administer the questionnaire among selected 2400 members of the Mano a Mano cohort. Regarding statistical methodology, we plan to complete the method proposed in our grant application by adjusting the inflated or deflated type I error and apply the completed procedure to the data collected in the project. For the isobole approach, we will finalize developing procedures that can combine the results of each isobole test for use of testing the overall interaction effect.
Journal Articles:
No journal articles submitted with this report: View all 5 publications for this projectSupplemental Keywords:
Air Pollution, Epidemiology, Exposure, Sensitive populations, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Risk Management, Health Risk Assessment, Risk Assessments, Biochemistry, Biology, cumulative exposure, cumulative risk, hypertension, air pollution, latino community, sensitive subjects, hispanics, cardiovascular disease, human health riskProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.
Project Research Results
- Final Report
- 2015 Progress Report
- 2014 Progress Report
- 2012 Progress Report
- 2011 Progress Report
- Original Abstract
3 journal articles for this project