Mechanistic Research Project

EPA Grant Number: R832141C003
Subproject: this is subproject number 003 , established and managed by the Center Director under grant R832141
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

Center: Columbia Center for Children’s Environmental Health
Center Director: Perera, Frederica P.
Title: Mechanistic Research Project
Investigators: Rothman, Paul B. , Chen, Lung Chi , Miller, Rachel L. , Grunig, Gabriele
Institution: Columbia University in the City of New York , New York University
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text |  Recipients Lists
Research Category: Children's Health , Human Health


The specific objectives of this research project are to determine whether: (1) in utero sensitization increases the risk for subsequent airway hyperreactivity and antigen-induced inflammation; (2) diesel exhaust particles, endemic to the Northern Manhattan environment, promote antigen-specific prenatal sensitization, if this occurs by upregulating Th2-mediated allergic responses, and if polycyclic aromatic hydrocarbons (PAHs), measured by PAH-adducts in lung tissue, mediates this response; and (3) endotoxin protects from the development of antigen-specific prenatal sensitization, and whether this occurs by upregulating Th1-mediated immune processes.

Supplemental Keywords:

children’s health, genetics, health effects, health risk assessment, assessment of exposure, endotoxins, PAHs, OVA, environmental risks, environmental exposure, exposure assessment, genetic risk factors, genetic susceptibility, maternal exposure, nutritional risk factors, diesel exhaust,, RFA, Health, Scientific Discipline, Air, INTERNATIONAL COOPERATION, ENVIRONMENTAL MANAGEMENT, air toxics, Genetics, Health Risk Assessment, Biochemistry, Children's Health, Environmental Policy, Risk Assessment, health effects, environmental risks, genetic mechanisms, Human Health Risk Assessment, diesel exhaust, PAH, assessment of exposure, genetic risk factors, children's environmental health, diesel exhaust particulate, exposure assessment, genetic susceptibility, maternal exposure

Progress and Final Reports:

  • 2004 Progress Report
  • 2005 Progress Report
  • 2006 Progress Report
  • 2007 Progress Report
  • 2008
  • 2009
  • Final

  • Main Center Abstract and Reports:

    R832141    Columbia Center for Children’s Environmental Health

    Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
    R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
    R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
    R832141C003 Mechanistic Research Project
    R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
    R832141C005 Community Translation and Application Core (COTAC)
    R832141C006 Exposure Assessment Facility Core
    R832141C007 Data Management, Statistics and Community Impact Modeling Core
    R832141C008 Administrative Core