Grantee Research Project Results

Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma

EPA Grant Number: R832141C002
Subproject: this is subproject number 002 , established and managed by the Center Director under grant R832141
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
Center: Water Environment and Reuse Foundation's National Center for Resource Recovery and Nutrient Management
Center Director: Olabode, Lola
Title: Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
Investigators: Rothman, Paul B. , Lederman, Sally Ann , Barr, R. Graham , Miller, Rachel L. , Sheares, Beverly , Goldstein, Inge
Institution: Columbia University in the City of New York
EPA Project Officer: Callan, Richard
Project Period: November 1, 2003 through October 31, 2008 (Extended to October 31, 2010)
RFA: Centers for Children's Environmental Health and Disease Prevention Research (2003) RFA Text | Recipients Lists
Research Category: Children's Health , Human Health

Objective:

The specific objectives of this research project are to: (1) determine the relationship between environmental exposures experienced prenatally through early childhood and atopy and adverse respiratory outcomes and asthma at age 5-7 years; (2) determine the interaction between susceptibility factors and environmental exposures on respiratory outcomes and asthma through age 5-7 years; (3) determine whether antigen-induced cord blood mononuclear cell proliferation or cytokine production increases the risk for decreased lung function or atopy at age 5 years among children with physician diagnosis of probable asthma at age 2 years or allergen-specific IgE levels at ages 2 and 3 years are associated with decreased lung function or atopy at age 5 years; and (4) collaborate with the Community Outreach, Translation and Application Core to ensure that asthma risk factors of concern to the community are being addressed, translate research findings back to the community, and assist in developing interventions and policies to prevent exposures that contribute to asthma and adverse respiratory health in New York City and elsewhere.

Publications and Presentations:

Publications have been submitted on this subproject: View all 2 publications for this subproject | View all 173 publications for this center

Journal Articles:

Journal Articles have been submitted on this subproject: View all 2 journal articles for this subproject | View all 158 journal articles for this center

Supplemental Keywords:

children’s health, health effects, health risk assessment, asthma, genetics, assessment of exposure, PAH, ETS, environmental risks, environmental exposure, exposure assessment, genetic risk factors, genetic susceptibility, maternal exposure, nutritional risk factors,, RFA, Scientific Discipline, Health, ENVIRONMENTAL MANAGEMENT, HUMAN HEALTH, Genetics, Health Risk Assessment, Epidemiology, Biochemistry, Health Effects, Children's Health, Risk Assessment, asthma, prenatal exposure, environmental risks, genetic mechanisms, Human Health Risk Assessment, diesel exhaust, assessment of exposure, genetic risk factors, children's environmental health, exposure assessment, genetic susceptibility, maternal exposure

Progress and Final Reports:

Main Center Abstract and Reports:

R832141 Water Environment and Reuse Foundation's National Center for Resource Recovery and Nutrient Management

Subprojects under this Center: (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R832141C001 Growth and Development Research Project: Prenatal and Postnatal Urban Pollutants and Neurobehavioral Developmental Outcomes
R832141C002 Research Project on Asthma: Prenatal and Postnatal Urban Pollutants and Childhood Asthma
R832141C003 Mechanistic Research Project
R832141C004 Community-Based Intervention Project: Reduction of Exposure and Risk from Pesticides and Allergens
R832141C005 Community Translation and Application Core (COTAC)
R832141C006 Exposure Assessment Facility Core
R832141C007 Data Management, Statistics and Community Impact Modeling Core
R832141C008 Administrative Core

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The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.