Grantee Research Project Results
Correlation of the CALUX Screening Assay with the HRGC/MS Measurement of Serum TCDD
EPA Grant Number: R831604Title: Correlation of the CALUX Screening Assay with the HRGC/MS Measurement of Serum TCDD
Investigators: Sweeney, Anne , del Junco, Deborah J. , Päpke, O.
Institution: Texas A & M University
EPA Project Officer: Aja, Hayley
Project Period: October 1, 2004 through September 30, 2005
Project Amount: $31,275
RFA: Issues in Human Health Risk Assessment (2001) RFA Text | Recipients Lists
Research Category: Pesticides , Human Health
Description:
Concerns have been raised recently regarding the validity and feasibility of using the chemically activated luciferase expression (CALUX) bioassay as a screening tool to measure dioxin exposure in large-scale epidemiologic studies. The objective of this research project was to validate the CALUX assay by comparison with the gold standard method, high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS), in 105 blood samples obtained from male Vietnam veterans during the period from 2001-2002. This grant was a follow-on to STAR Grant No. R825817.
Supplemental Keywords:
risk assessment, exposure, dioxin, PCDD, PCDF, TCDD, epidemiology,, Health, RFA, Scientific Discipline, PESTICIDES, Toxics, Susceptibility/Sensitive Population/Genetic Susceptibility, Risk Assessments, Chemistry, Biology, genetic susceptability, Epidemiology, Pesticide Types, Genetics, bioassay, sensitive populations, environmental hazard exposures, dioxin, human exposure, P450 genes, genetic polymorphisms, genetic susceptibility, exposure, Vietnam veterans, dioxin exposure, environmentally caused disease, reproductive health, human susceptibility, herbicidesProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.