Grantee Research Project Results
2006 Progress Report: Acute and Developmental Toxicity of Metal Oxide Nanoparticles in Fish and Frogs
EPA Grant Number: R832842Title: Acute and Developmental Toxicity of Metal Oxide Nanoparticles in Fish and Frogs
Investigators: Theodorakis, Christopher , Carraway, Elizabeth , Cobb, George
Institution: Southern Illinois University - Edwardsville , Towson University , Clemson University
Current Institution: Southern Illinois University - Edwardsville , Clemson University , Towson University
EPA Project Officer: Aja, Hayley
Project Period: October 24, 2005 through October 24, 2008
Project Period Covered by this Report: October 24, 2005 through October 24, 2006
Project Amount: $375,000
RFA: Exploratory Research: Nanotechnology Research Grants Investigating Environmental and Human Health Effects of Manufactured Nanomaterials: A Joint Research Solicitation - EPA, NSF, NIOSH (2005) RFA Text | Recipients Lists
Research Category: Nanotechnology , Human Health , Safer Chemicals
Objective:
The objectives of this research are to determine the environmental hazard associated with selected metal oxide nanoparticles (Fe2O3, ZnO, CuO, and TiO2), in terms of acute and chronic toxicity to fathead minnows (Pimephase promelas) and the African clawed frog (Xenopus laevis).
Progress Summary:
Due to delays caused by my changing institutions and other circumstances beyond my control, I did not have access to funds from my grant until 1 July 2006. Furthermore, I this grant was approved in summer of 2005, when I was still at Texas Tech University, but after I had accepted the position at Southern Illinois University Edwardsville and had made plans to move in August 2005. The transition caused further delays in starting this project, because it took months to get my lab set up and get personnel in place to do the work at SIUE.
Therefore, most of the activity during this period involved ordering supplies, animals, reagents, and equipment, setting up the laboratory, and performing feasibility studies. Flow-through chambers for exposure of fathead minnows to nanoparticles are being constructed. Range-finding tests for acute toxicity of nanoparticles to clawed frogs are underway.
Future Activities:
Acute toxicity of ZnO, CuO, TiO2, and Fe2O3 will be determined in clawed frogs will begin shortly.
Journal Articles:
No journal articles submitted with this report: View all 13 publications for this projectSupplemental Keywords:
Water, animal, ecosystem, aquatic, biology, Southwest, Midwest,, Health, Scientific Discipline, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Risk Assessments, Environmental Chemistry, Biochemistry, Risk Assessment, bioavailability, nanomaterials, animal bioassays, animal model, nanotechnology, nanochemistry, nanoparticle toxicity, exposure assessmentProgress and Final Reports:
Original AbstractThe perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.