Grantee Research Project Results
Interaction of Chromium and Arsenic in Human Lung Cells and the Role of the Fanc Pathway
EPA Grant Number: F5D40827Title: Interaction of Chromium and Arsenic in Human Lung Cells and the Role of the Fanc Pathway
Investigators: Savery, Laura C.
Institution: University of Southern Maine
EPA Project Officer: Packard, Benjamin H
Project Period: September 6, 2005 through September 6, 2008
Project Amount: $96,175
RFA: STAR Graduate Fellowships (2005) RFA Text | Recipients Lists
Research Category: Academic Fellowships
Objective:
To examine the toxic interactions between chromium and arsenic and determine if co-exposure to arsenic exacerbates the toxic effects of chromium.
Approach:
Integrate toxicogenomic and genetic toxicology approaches using cytotoxicity and uptake assays, chromosome damage assays, comet assays and microarrays to investigate the toxic interactions of chromium and arsenic.
Expected Results:
Arsenic potentiates the carcinogenicity of hexavalent chromium (Cr(VI)) by inhibiting the repair of chromate-induced DNA lesions leading to an increase in chromate-induced chromosomal instability and alterations in gene expression.
Supplemental Keywords:
chromium, arsenic, genotoxicity, chromosome damage, chromosome instability,, Health, Scientific Discipline, Environmental Chemistry, Health Risk Assessment, Risk Assessments, Biochemistry, particulate matter, particle size, chemical exposure, lung injury, chromosome damage assays, cytokines, acute lung injury, nanotechnology, combustion emissions, particle exposure, chemical mixtures, ambient particle health effects, human exposure, respiratory impact, inhalation toxicology, chromium speciation, inhalation study, fanc pathway, biochemical research, human health risk, ultrafine particles, analysis of chemical exposure, arsenic, combination exposureProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.