Grantee Research Project Results
Interaction of Chromium and Arsenic in Human Lung Cells and the Role of the Fanc PathwayEPA Grant Number: F5D40827
Title: Interaction of Chromium and Arsenic in Human Lung Cells and the Role of the Fanc Pathway
Investigators: Savery, Laura C.
Institution: University of Southern Maine
EPA Project Officer: Packard, Benjamin H
Project Period: September 6, 2005 through September 6, 2008
Project Amount: $96,175
RFA: STAR Graduate Fellowships (2005) RFA Text | Recipients Lists
Research Category: Academic Fellowships
To examine the toxic interactions between chromium and arsenic and determine if co-exposure to arsenic exacerbates the toxic effects of chromium.
Integrate toxicogenomic and genetic toxicology approaches using cytotoxicity and uptake assays, chromosome damage assays, comet assays and microarrays to investigate the toxic interactions of chromium and arsenic.
Arsenic potentiates the carcinogenicity of hexavalent chromium (Cr(VI)) by inhibiting the repair of chromate-induced DNA lesions leading to an increase in chromate-induced chromosomal instability and alterations in gene expression.