Grantee Research Project Results
TCDD-Induced Insulin Resistance
EPA Grant Number: R827685E03Title: TCDD-Induced Insulin Resistance
Investigators: Kern, Philip A. , Kennedy, Richard H.
Institution: University of Arkansas for Medical Sciences
EPA Project Officer: Chung, Serena
Project Period: August 1, 1999 through July 31, 2001
RFA: EPSCoR (Experimental Program to Stimulate Competitive Research) (1999) RFA Text | Recipients Lists
Research Category: EPSCoR (The Experimental Program to Stimulate Competitive Research)
Objective:
The objective of this
research project was to examine the role of environmental dioxin exposure in
the development
of insulin resistance, a prediabetic state in which normal blood glucose levels
are maintained by high circulating levels of insulin. The most toxic of the
dioxin compounds is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). TCDD was the
primary dioxin component of "Agent Orange" and has been found at
numerous toxic waste sites, including the Vertac Superfund site in Jacksonville,
AR. Thus, the problem is not limited to Vietnam veterans; many Americans have
been exposed to TCDD. The objectives of this project were to document further
this pathology in humans, and to use an animal model to determine if the toxic
mechanism includes effects on tumor necrosis factor (TNF)-, glucose transporters,
lipase activities, or peroxisome proliferator-activated receptor-
.
Publications and Presentations:
Publications have been submitted on this project: View all 3 publications for this projectJournal Articles:
Journal Articles have been submitted on this project: View all 3 journal articles for this projectSupplemental Keywords:
health effects, mammalian, sensitive populations, 2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD, insulin, Experimental Program to Stimulate Competitive Research, EPSCoR, Science and Engineering Environmental Research, SEER, dioxin, Agent Orange, toxic, Arkansas, AR, Vertac/Hercules Superfund Site., Health, Scientific Discipline, Geographic Area, ENVIRONMENTAL MANAGEMENT, Health Risk Assessment, Risk Assessments, State, Environmental Chemistry, Risk Assessment, toxic environmental contaminants, insulin resistance, dioxin, human exposure, TCDD, assessment technology, Arkansas, dioxin exposure, comparative metabolism, tumor necrosis factor, human health risk, Agent OrangeProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.