Grantee Research Project Results
Mechanistic Evaluation of the Toxicity of Chemical Mixtures
EPA Grant Number: R829358Title: Mechanistic Evaluation of the Toxicity of Chemical Mixtures
Investigators: LeBlanc, Gerald A.
Institution: North Carolina State University
EPA Project Officer: Hahn, Intaek
Project Period: September 24, 2001 through September 23, 2006
Project Amount: $465,281
RFA: Complex Chemical Mixtures (2000) RFA Text | Recipients Lists
Research Category: Hazardous Waste/Remediation , Environmental Justice , Safer Chemicals , Land and Waste Management
Description:
Evaluating the toxicity of complex chemical mixtures is one of the major challenges facing modern toxicology. The general hypothesis to be tested in this research is that the toxicity of complex chemical mixtures can be satisfactorily estimated by understanding the mechanisms of chemical toxicity of the individual constituents and utilizing algorithms that define interactions based upon these mechanisms.
Approach:
Model chemicals will be evaluated for both acute and chronic toxicity using the daphnid (Daphnia magna) as a model organism. Daphnids are ideally suited to this program since they are non-vertebrate whole organisms that are highly amenable to laboratory study. Concentration-response curves will be determined for each chemical that will provide the mechanistic data necessary to formulate algorithms that define the toxicity of binary, tertiary, etc. combinations of the chemicals. Mathematical predictions of mixtures toxicity will be compared to actual experimental results.
Expected Results:
Results from this research program will provide a solid research framework to structure evaluations of the toxicity of complex chemical mixtures. The framework will be highly adaptable for use in human health and environmental health assessments of the toxicity of mixtures. Further, the framework will be applicable for use in both retrospective and prospective assessments of the hazards of chemical mixtures.
Publications and Presentations:
Publications have been submitted on this project: View all 29 publications for this projectJournal Articles:
Journal Articles have been submitted on this project: View all 17 journal articles for this projectSupplemental Keywords:
modeling, hazard characterization, hazard wastes, risk., RFA, Ecosystem Protection/Environmental Exposure & Risk, Scientific Discipline, Waste, Hazardous, Fate & Transport, chemical mixtures, Environmental Chemistry, Hazardous Waste, Ecology and Ecosystems, environmental transport and fate, hazardous organic substances, toxicity testing, contaminated sediments, complex toxic chemical mixtures, mechanisitic research, analytical models, fate and transport , biodegradation, complex mixtures, fate and transport, chemical kinetics, contaminant transport modelsProgress and Final Reports:
The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Conclusions drawn by the principal investigators have not been reviewed by the Agency.